Literature DB >> 25859483

Normokalemic thyrotoxic periodic paralysis with preserved reflexes- a unique case report.

Subrata Chakrabarti1.   

Abstract

Although serum potassium levels are usually subnormal in Thyrotoxic Periodic Paralysis (TPP), but in exceptionally rare circumstances, it may be normal leading to the entity called normokalemic TPP. The diagnosis of normokalemic TPP is more often overlooked and/or delayed due to lack of awareness among the physicians and associated mild symptoms of hyperthyroidism. Here, the author describes the case of a 27-year-old male with newly diagnosed but untreated Grave's disease and TPP who was normokalemic during the acute phase of paralysis. Hypokalemia was documented only after resolution of paralytic attacks during subsequent days of admission. The importance of the case report is to highlight upon the fact that TPP should always be considered in an "previously asymptomatic" young Asian individual with acute paralysis with or without hypokalemia , and thyroid function and serial potassium values should be evaluated for diagnosing the usual hypokalemic type or the more rarer variant normokalemic TPP. This case report also deserves mention as the patient of TPP had a notable feature of having preserved reflexes in the face of hypokalemia.

Entities:  

Keywords:  Hypokalemia; Paresthesia; Thyrotoxicosis

Year:  2015        PMID: 25859483      PMCID: PMC4378765          DOI: 10.7860/JCDR/2015/11034.5538

Source DB:  PubMed          Journal:  J Clin Diagn Res        ISSN: 0973-709X


  8 in total

1.  Clinical and metabolic features of thyrotoxic periodic paralysis in 24 episodes.

Authors:  M A Manoukian; J A Foote; L M Crapo
Journal:  Arch Intern Med       Date:  1999-03-22

Review 2.  Thyrotoxic periodic paralysis.

Authors:  C H Magsino; A J Ryan
Journal:  South Med J       Date:  2000-10       Impact factor: 0.954

Review 3.  Clinical review: Thyrotoxic periodic paralysis: a diagnostic challenge.

Authors:  Annie W C Kung
Journal:  J Clin Endocrinol Metab       Date:  2006-04-11       Impact factor: 5.958

4.  A 32-year-old Man with Normokalemic Thyrotoxic Periodic Paralysis.

Authors:  Neda Valizadeh; Sahar Zarrin
Journal:  Malays J Med Sci       Date:  2013-01

5.  An unrecognized cause of paralysis in ED: thyrotoxic normokalemic periodic paralysis.

Authors:  Chia-Chao Wu; Tom Chau; Chao-Jiieh Chang; Shih-Hua Lin
Journal:  Am J Emerg Med       Date:  2003-01       Impact factor: 2.469

6.  Fatal thyrotoxic periodic paralysis with normokalemia.

Authors:  Nitin Satam; Vaishali More; Preeti Shanbag; Alka Kalgutkar
Journal:  Indian J Pediatr       Date:  2007-11       Impact factor: 1.967

7.  Mutations in potassium channel Kir2.6 cause susceptibility to thyrotoxic hypokalemic periodic paralysis.

Authors:  Devon P Ryan; Magnus R Dias da Silva; Tuck Wah Soong; Bertrand Fontaine; Matt R Donaldson; Annie W C Kung; Wallaya Jongjaroenprasert; Mui Cheng Liang; Daphne H C Khoo; Jin Seng Cheah; Su Chin Ho; Harold S Bernstein; Rui M B Maciel; Robert H Brown; Louis J Ptácek
Journal:  Cell       Date:  2010-01-08       Impact factor: 41.582

Review 8.  Thyrotoxic periodic paralysis: clinical challenges.

Authors:  Abhishek Vijayakumar; Giridhar Ashwath; Durganna Thimmappa
Journal:  J Thyroid Res       Date:  2014-02-20
  8 in total
  2 in total

1.  Hypokalaemic Periodic Paralysis in a Patient with Subclinical Hyperthyroidism: A Rare Case.

Authors:  Swati Hegde; Mohammed Aslam Shaikh; Thejaswi Gummadi
Journal:  J Clin Diagn Res       Date:  2016-01-01

2.  Normokalemic Thyrotoxic Periodic Paralysis with Acute Resolution in the Emergency Department.

Authors:  James I Gragg; Massimo Federico; Larry B Mellick
Journal:  Clin Pract Cases Emerg Med       Date:  2017-03-15
  2 in total

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