Velu Nair1, Dinesh Sharma2, A K Sahni3, Naveen Grover4, S Shankar5, S S Jaiswal6, S S Dalal7, D R Basannar8, Vivek S Phutane9, Atul Kotwal10, G Gopal Rao11, Deepak Batura12, M D Venkatesh13, Tapan Sinha14, Sushil Kumar15, D P Joshi16. 1. Senior Consultant (Medicine), O/O DGAFMS, Ministry of Defence, M Block, New Delhi 110001, India. 2. Professor, Department of Community Medicine, Armed Forces Medical College, Pune 411040, India. 3. Commandant, 174 Military Hospital, C/O 56 APO, India. 4. Associate Professor, Department of Microbiology, Armed Forces Medical College, Pune 411040, India. 5. Senior Advisor (Medicine), Command Hospital (Air Force), Bengaluru, India. 6. Associate Professor, Department of Surgery, Armed Forces Medical College, Pune 411040, India. 7. Associate Professor, Department of Paediatrics, Armed Forces Medical College, Pune 411040, India. 8. Scientist 'F', Department of Community Medicine, Armed Forces Medical College, Pune 411040, India. 9. Resident, Department of Community Medicine, Armed Forces Medical College, Pune 411040, India. 10. Commandant, 153 General Hospital, C/O 56 APO, India. 11. Honorary Senior Lecturer, Imperial College, London, UK. 12. Consultant, London North West Healthcare NHS Trust, London, UK. 13. Dean & Deputy Commandant, Armed Forces Medical College, Pune 411040, India. 14. DGMS (Navy), IHQ MoD (Navy), New Delhi 110001, India. 15. Director and Commandant, Armed Forces Medical College, Pune 411040, India. 16. Ex-DGAFMS, O/o DGAFMS, New Delhi 110001, India.
Abstract
BACKGROUND: Resistance to antimicrobial agents is emerging in wide variety of nosocomial and community acquired pathogens. Widespread and often inappropriate use of broad spectrum antimicrobial agents is recognized as a significant contributing factor to the development and spread of bacterial resistance. This study was conducted to gain insight into the prevalent antimicrobial prescribing practices, and antimicrobial resistance pattern in nosocomial pathogens at a tertiary care hospital in Pune, India. METHODS: Series of one day cross sectional point prevalence surveys were carried out on four days between March and August 2014. All eligible in patients were included in the study. A structured data entry form was used to collect the data for each patient. Relevant samples were collected for microbiological examination from all the clinically identified hospital acquired infection cases. RESULTS: 41.73% of the eligible patients (95% CI: 39.52-43.97) had been prescribed at least one antimicrobial during their stay in the hospital. Beta-lactams (38%) were the most prescribed antimicrobials, followed by Protein synthesis inhibitors (24%). Majority of the organisms isolated from Hospital acquired infection (HAI cases) were found to be resistant to the commonly used antimicrobials viz: Cefotaxime, Ceftriaxone, Amikacin, Gentamicin and Monobactams. CONCLUSION: There is need to have regular antimicrobial susceptibility surveillance and dissemination of this information to the clinicians. In addition, emphasis on the rational use of antimicrobials, antimicrobial rotation and strict adherence to the standard treatment guidelines is very essential.
BACKGROUND: Resistance to antimicrobial agents is emerging in wide variety of nosocomial and community acquired pathogens. Widespread and often inappropriate use of broad spectrum antimicrobial agents is recognized as a significant contributing factor to the development and spread of bacterial resistance. This study was conducted to gain insight into the prevalent antimicrobial prescribing practices, and antimicrobial resistance pattern in nosocomial pathogens at a tertiary care hospital in Pune, India. METHODS: Series of one day cross sectional point prevalence surveys were carried out on four days between March and August 2014. All eligible in patients were included in the study. A structured data entry form was used to collect the data for each patient. Relevant samples were collected for microbiological examination from all the clinically identified hospital acquired infection cases. RESULTS: 41.73% of the eligible patients (95% CI: 39.52-43.97) had been prescribed at least one antimicrobial during their stay in the hospital. Beta-lactams (38%) were the most prescribed antimicrobials, followed by Protein synthesis inhibitors (24%). Majority of the organisms isolated from Hospital acquired infection (HAI cases) were found to be resistant to the commonly used antimicrobials viz: Cefotaxime, Ceftriaxone, Amikacin, Gentamicin and Monobactams. CONCLUSION: There is need to have regular antimicrobial susceptibility surveillance and dissemination of this information to the clinicians. In addition, emphasis on the rational use of antimicrobials, antimicrobial rotation and strict adherence to the standard treatment guidelines is very essential.
Authors: S K Fridkin; C D Steward; J R Edwards; E R Pryor; J E McGowan; L K Archibald; R P Gaynes; F C Tenover Journal: Clin Infect Dis Date: 1999-08 Impact factor: 9.079
Authors: A S Levin; C M Mendes; S I Sinto; H S Sader; C R Scarpitta; E Rodrigues; N Sauaia; M Boulos Journal: Infect Control Hosp Epidemiol Date: 1996-06 Impact factor: 3.254
Authors: M Ogwang; D Paramatti; T Molteni; E Ochola; T R Okello; J C Ortiz Salgado; A Kayanja; C Greco; D Kizza; E Gondoni; J Okot; L Praticò; V Granata; A Filia; H Kellar Ayugi; D Greco Journal: J Hosp Infect Date: 2013-05-01 Impact factor: 3.926
Authors: S Handwerger; B Raucher; D Altarac; J Monka; S Marchione; K V Singh; B E Murray; J Wolff; B Walters Journal: Clin Infect Dis Date: 1993-06 Impact factor: 9.079
Authors: D A Goldmann; R A Weinstein; R P Wenzel; O C Tablan; R J Duma; R P Gaynes; J Schlosser; W J Martone Journal: JAMA Date: 1996-01-17 Impact factor: 56.272
Authors: P Zarb; B Coignard; J Griskeviciene; A Muller; V Vankerckhoven; K Weist; Mm Goossens; S Vaerenberg; S Hopkins; B Catry; Dl Monnet; H Goossens; C Suetens Journal: Euro Surveill Date: 2012-11-15
Authors: Feras Darwish Elhajji; Ghaith M Al-Taani; Lana Anani; Sahar Al-Masri; Haneen Abdalaziz; Su'ad H Qabba'h; Abdel Qader Al Bawab; Michael Scott; David Farren; Fiona Gilmore; Ann Versporten; Herman Goossens; Mamoon A Aldeyab Journal: BMC Health Serv Res Date: 2018-11-12 Impact factor: 2.655
Authors: Marco Golfera; Fabrizio Toscano; Gabriele Cevenini; Maria F DE Marco; Barbara R Porchia; Andrea Serafini; Emma Ceriale; Daniele Lenzi; Gabriele Messina Journal: J Prev Med Hyg Date: 2022-07-31