Saknan Manotaya1, Juergen Zitzler2, Xiaotian Li3, Noroyono Wibowo4, Thi Mai Pham5, Myung Seo Kang6, Chien-Nan Lee7. 1. Department of Obstetrics and Gynaecology, Faculty of Medicine, Chulalongkorn University, Patumwan, Bangkok, Thailand. 2. Roche Diagnostics, Clinical Operations Professional Diagnostics, Penzberg, Germany. 3. Obstetrics and Gynaecology Hospital of Fudan University, Shanghai, China. 4. Department of Obstetrics and Gynaecology, Division Fetomaternal, FKUI/RSCM, Jakarta, Indonesia. 5. Department of Obstetrics and Gynaecology, Medical University Hospital, Ho Chi Minh City, Vietnam. 6. Department of Laboratory Medicine, CHA Bundang Medical Center, CHA University, Bundang-gu, Seongnam-si, Korea. 7. Department of Obstetrics, National Taiwan University Hospital, Taipei, Taiwan.
Abstract
OBJECTIVE: To assess differences between first trimester trisomy 21 screening markers free beta chain of the human chorionic gonadotrophin (βhCG) and pregnancy-associated plasma protein A (PAPP-A) in pregnant women of six different Asian countries (China, Indonesia, Korea, Taiwan, Thailand, and Vietnam) and compare serum levels with those in women of European countries. METHODS: Median and multiple of median (MoM) values of free βhCG and PAPP-A were determined in more than 3000 pregnant women from the Asian countries during their first trimester of pregnancy. Differences in MoM values between a European reference group from a previous multicenter evaluation and the Asian population were evaluated. Two different types of population correction factors for T21 risk estimation were assessed. RESULTS: An at least 10% difference of median MoMs between European and Asian PAPP-A values was found to be statistically significant (p < 0.0001). The specificity of the screening did not show a big difference in individual countries, when using the country-specific correction factor compared with the overall Asian correction factor (<1.4%). CONCLUSIONS: The use of a correction factor is recommended based on the differences in European and Asian MoM values. Developing country-specific medians in larger study populations can help identify clinical relevant differences and give the opportunity to explore a more accurate risk calculation.
OBJECTIVE: To assess differences between first trimester trisomy 21 screening markers free beta chain of the human chorionic gonadotrophin (βhCG) and pregnancy-associated plasma protein A (PAPP-A) in pregnant women of six different Asian countries (China, Indonesia, Korea, Taiwan, Thailand, and Vietnam) and compare serum levels with those in women of European countries. METHODS: Median and multiple of median (MoM) values of free βhCG and PAPP-A were determined in more than 3000 pregnant women from the Asian countries during their first trimester of pregnancy. Differences in MoM values between a European reference group from a previous multicenter evaluation and the Asian population were evaluated. Two different types of population correction factors for T21 risk estimation were assessed. RESULTS: An at least 10% difference of median MoMs between European and Asian PAPP-A values was found to be statistically significant (p < 0.0001). The specificity of the screening did not show a big difference in individual countries, when using the country-specific correction factor compared with the overall Asian correction factor (<1.4%). CONCLUSIONS: The use of a correction factor is recommended based on the differences in European and Asian MoM values. Developing country-specific medians in larger study populations can help identify clinical relevant differences and give the opportunity to explore a more accurate risk calculation.
Authors: Joyce L Browne; Kerstin Klipstein-Grobusch; Maria P H Koster; Dhivya Ramamoorthy; Edward Antwi; Idder Belmouden; Arie Franx; Diederick E Grobbee; Peter C J I Schielen Journal: PLoS One Date: 2016-08-17 Impact factor: 3.240
Authors: Edward Antwi; Kerstin Klipstein-Grobusch; Joyce L Browne; Peter C Schielen; Kwadwo A Koram; Irene A Agyepong; Diederick E Grobbee Journal: Reprod Health Date: 2018-03-27 Impact factor: 3.223