Minoru Yamada1, Shu Nishiguchi2, Naoto Fukutani2, Tomoki Aoyama2, Hidenori Arai3. 1. Department of Lifespan Development Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tokyo, Japan. Electronic address: m-yamada@human.tsukuba.ac.jp. 2. Department of Human Health Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan. 3. National Center for Geriatrics and Gerontology, Aichi, Japan.
Abstract
OBJECTIVE: The aim of the Intervention by Nutrition and Exercise (INE) study was to investigate the effects of a mail-based intervention for sarcopenia prevention on muscle mass and anabolic hormones in community-dwelling older adults. DESIGN: A cluster-randomized controlled trial. SETTING AND PARTICIPANTS: This trial recruited community-dwelling adults aged 65 years and older in Japan. The 227 participants were cluster randomized into awalking and nutrition (W/N) group (n = 79), a walking (W) group (n = 71), and a control (C) group (n = 77). We analyzed the physical and biochemical measurements in this substudy. INTERVENTION: Six months of mail-based intervention (a pedometer-based walking program and nutritional supplementation). MEASUREMENTS: The skeletal muscle mass index (SMI) using the bioelectrical impedance data acquisition system, biochemical measurements, such as those of insulinlike growth factor (IGF-1), dehydroepiandrosterone sulfate (DHEA-S), and 25-hydroxy vitamin D (25[OH]D), as well as frailty, were assessed by the Cardiovascular Health Study criteria. RESULTS: Participants in the W/N and W groups had significantly greater improvements in SMI, IGF-1, and 25(OH)D (P < .05) than those in the C group. Participants in the W/N group had significantly greater improvements in DHEA-S (P < .05) than in the other groups. These effects were more pronounced in frail, older adults. CONCLUSION: These results suggest that the mail-based walking intervention of the remote monitoring type for sarcopenia prevention can increase anabolic hormone levels and SMI in community-dwelling older adults, particularly in those who are frail.
RCT Entities:
OBJECTIVE: The aim of the Intervention by Nutrition and Exercise (INE) study was to investigate the effects of a mail-based intervention for sarcopenia prevention on muscle mass and anabolic hormones in community-dwelling older adults. DESIGN: A cluster-randomized controlled trial. SETTING AND PARTICIPANTS: This trial recruited community-dwelling adults aged 65 years and older in Japan. The 227 participants were cluster randomized into a walking and nutrition (W/N) group (n = 79), a walking (W) group (n = 71), and a control (C) group (n = 77). We analyzed the physical and biochemical measurements in this substudy. INTERVENTION: Six months of mail-based intervention (a pedometer-based walking program and nutritional supplementation). MEASUREMENTS: The skeletal muscle mass index (SMI) using the bioelectrical impedance data acquisition system, biochemical measurements, such as those of insulinlike growth factor (IGF-1), dehydroepiandrosterone sulfate (DHEA-S), and 25-hydroxy vitamin D (25[OH]D), as well as frailty, were assessed by the Cardiovascular Health Study criteria. RESULTS:Participants in the W/N and W groups had significantly greater improvements in SMI, IGF-1, and 25(OH)D (P < .05) than those in the C group. Participants in the W/N group had significantly greater improvements in DHEA-S (P < .05) than in the other groups. These effects were more pronounced in frail, older adults. CONCLUSION: These results suggest that the mail-based walking intervention of the remote monitoring type for sarcopenia prevention can increase anabolic hormone levels and SMI in community-dwelling older adults, particularly in those who are frail.
Authors: Samuel Golpanian; Darcy L DiFede; Aisha Khan; Ivonne Hernandez Schulman; Ana Marie Landin; Bryon A Tompkins; Alan W Heldman; Roberto Miki; Bradley J Goldstein; Muzammil Mushtaq; Silvina Levis-Dusseau; John J Byrnes; Maureen Lowery; Makoto Natsumeda; Cindy Delgado; Russell Saltzman; Mayra Vidro-Casiano; Marietsy V Pujol; Moisaniel Da Fonseca; Anthony A Oliva; Geoff Green; Courtney Premer; Audrey Medina; Krystalenia Valasaki; Victoria Florea; Erica Anderson; Jill El-Khorazaty; Adam Mendizabal; Pascal J Goldschmidt-Clermont; Joshua M Hare Journal: J Gerontol A Biol Sci Med Sci Date: 2017-10-12 Impact factor: 6.053
Authors: C Beaudart; A Dawson; S C Shaw; N C Harvey; J A Kanis; N Binkley; J Y Reginster; R Chapurlat; D C Chan; O Bruyère; R Rizzoli; C Cooper; E M Dennison Journal: Osteoporos Int Date: 2017-03-01 Impact factor: 4.507