| Literature DB >> 25857253 |
Victoria Fasick1, Robert N Spengler2, Shabnam Samankan1, Nader D Nader3, Tracey A Ignatowski4.
Abstract
Major depression and chronic pain are significant health problems that seriously impact the quality of life of affected individuals. These diseases that individually are difficult to treat often co-exist, thereby compounding the patient's disability and impairment as well as the challenge of successful treatment. The development of efficacious treatments for these comorbid disorders requires a more comprehensive understanding of their linked associations through common neuromodulators, such as tumor necrosis factor-α (TNFα), and various neurotransmitters, as well as common neuroanatomical pathways and structures, including the hippocampal brain region. This review discusses the interaction between depression and chronic pain, emphasizing the fundamental role of the hippocampus in the development and maintenance of both disorders. The focus of this review addresses the hypothesis that hippocampal expressed TNFα serves as a therapeutic target for management of chronic pain and major depressive disorder (MDD).Entities:
Keywords: Brain; Chronic pain; Comorbid; Depression; Hippocampus; Tumor necrosis factor-α
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Year: 2015 PMID： 25857253 DOI： 10.1016/j.neubiorev.2015.03.014
Source DB: PubMed Journal: Neurosci Biobehav Rev ISSN： 0149-7634 Impact factor: 8.989