Jing Yang1, Fei Zhong2, Ju Qiu3, Kai Wang4. 1. Department of Neurology, The Affiliated Anhui Provincial Hospital, Anhui Medical University, Hefei, China. 2. Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, China. 3. Department of Neurology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China. 4. Laboratory of Neuropsychology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Abstract
AIMS: Androgen-deprivation therapy (ADT) is a main treatment option for patients with prostate cancer (PCa), but its effect on cognition remains unclear. The primary purpose of this cross-sectional case-control study was to evaluate the effects of ADT on cognition in Chinese PCa patients. METHODS: Participants included PCa patients who had undergone ADT (ADT group, n = 33) and patients who did not undergo ADT (non-ADT group, n = 32), as well as age- and education-matched healthy controls (HC group, n = 35). All participants were examined using the neuropsychological battery aimed at assessing several cognitive domains including attention, memory and information processing performance. RESULTS: The ADT group obtained significantly worse scores than the non-ADT and HC groups in the following neuropsychological tests: Recognition (P < 0.01), WAIS Digit Span forward (P < 0.05), Trailmaking B (P < 0.01) and Stroop Interference test (P < 0.01). No significant difference was found between the non-ADT and HC groups (P > 0.05). CONCLUSIONS: Chinese PCa patients receiving ADT showed cognitive impairments in several domains including memory, attention and information processing performance.
AIMS: Androgen-deprivation therapy (ADT) is a main treatment option for patients with prostate cancer (PCa), but its effect on cognition remains unclear. The primary purpose of this cross-sectional case-control study was to evaluate the effects of ADT on cognition in Chinese PCa patients. METHODS:Participants included PCa patients who had undergone ADT (ADT group, n = 33) and patients who did not undergo ADT (non-ADT group, n = 32), as well as age- and education-matched healthy controls (HC group, n = 35). All participants were examined using the neuropsychological battery aimed at assessing several cognitive domains including attention, memory and information processing performance. RESULTS: The ADT group obtained significantly worse scores than the non-ADT and HC groups in the following neuropsychological tests: Recognition (P < 0.01), WAIS Digit Span forward (P < 0.05), Trailmaking B (P < 0.01) and Stroop Interference test (P < 0.01). No significant difference was found between the non-ADT and HC groups (P > 0.05). CONCLUSIONS: Chinese PCa patients receiving ADT showed cognitive impairments in several domains including memory, attention and information processing performance.
Authors: Cornelie D Andela; Rafil Matte; Ingrid M Jazet; Willemijn Cg Zonneveld; Jan W Schoones; A Edo Meinders Journal: Int J Urol Date: 2021-06-14 Impact factor: 2.896