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Literature DB >> 25856749

Host autophagy combating S. aureus: α-toxin will be tolerated.

Michael E Powers¹, Juliane Bubeck Wardenburg².

Abstract

Autophagy regulates the degradation of both cellular components and invading intracellular pathogens. In this issue of Cell Host & Microbe, Maurer et al. (2015) reveal that cellular autophagy decreases host sensitivity to Staphylococcus aureus α-toxin via reduced expression of the toxin receptor ADAM10, thus rendering the host tolerant to disease.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2015 PMID： 25856749 PMCID： PMC4642995 DOI： 10.1016/j.chom.2015.03.010

Source DB: PubMed Journal: Cell Host Microbe ISSN： 1931-3128 Impact factor: 21.023

11 in total

1. Role of a disintegrin and metalloprotease 10 in Staphylococcus aureus alpha-hemolysin-mediated cellular injury.

Authors: Georgia A Wilke; Juliane Bubeck Wardenburg
Journal: Proc Natl Acad Sci U S A Date: 2010-07-12 Impact factor: 11.205

2. A deficiency in the autophagy gene Atg16L1 enhances resistance to enteric bacterial infection.

Authors: Amanda M Marchiando; Deepshika Ramanan; Yi Ding; Luis E Gomez; Vanessa M Hubbard-Lucey; Katie Maurer; Caihong Wang; Joshua W Ziel; Nico van Rooijen; Gabriel Nuñez; B Brett Finlay; Indira U Mysorekar; Ken Cadwell
Journal: Cell Host Microbe Date: 2013-08-14 Impact factor: 21.023

Host autophagy combating S. aureus: α-toxin will be tolerated.

1. Role of a disintegrin and metalloprotease 10 in Staphylococcus aureus alpha-hemolysin-mediated cellular injury.

2. A deficiency in the autophagy gene Atg16L1 enhances resistance to enteric bacterial infection.

3. Autophagy mediates tolerance to Staphylococcus aureus alpha-toxin.

4. ADAM10 mediates vascular injury induced by Staphylococcus aureus α-hemolysin.

5. Rapamycin promotes beta-amyloid production via ADAM-10 inhibition.

6. Alpha-hemolysin is required for the activation of the autophagic pathway in Staphylococcus aureus-infected cells.

7. Staphylococcus aureus subvert autophagy for induction of caspase-independent host cell death.

8. Surface proteins and exotoxins are required for the pathogenesis of Staphylococcus aureus pneumonia.

9. A Staphylococcus aureus pore-forming toxin subverts the activity of ADAM10 to cause lethal infection in mice.

Review 10. Bacteria-autophagy interplay: a battle for survival.

1. Cosmosiin Increases ADAM10 Expression via Mechanisms Involving 5'UTR and PI3K Signaling.

Review 2. Interactions between Autophagy and Bacterial Toxins: Targets for Therapy?