| Literature DB >> 25855385 |
Xiangyu Fan1,2, Abu Algasim Elgaili Abd Alla1, Jianping Xie1.
Abstract
Mycobacterium tuberculosis complex (MTBC) is notorious for causing diseases, such as tuberculosis. Tuberculosis caused by M. tuberculosis remains a global public health concern. Two prophages, phiRv1 and phiRv2, can be found among most MTBC genomes. However, no precise functions have been assigned for the two prophages. In this paper, to find out the function of these two prophages, the distribution and function of phiRv1 and phiRv2 in MTBC genomes were analyzed from multiple omics data. We found that complex insertion, deletion, and reorganization appeared on the locus of two prophages in MTBC genomes; some genes of the two prophages can be translated and are functional from proteomic data; the expression of other prophage genes, such as Rv1577c, Rv2650c, Rv2652c, Rv2659c, and Rv2658c, can vary with environmental stresses and might enhance the fitness of MTBC. These data will facilitate our in-depth understanding of their function.Entities:
Keywords: Mycobacterium tuberculosis complex; genome; prophage; proteome; transcriptomic
Mesh：
Year: 2015 PMID： 25855385 DOI： 10.1080/07391102.2015.1022602
Source DB: PubMed Journal: J Biomol Struct Dyn ISSN： 0739-1102