Anadeep Chandi1,2, Daya Sirohiwal3, Roopa Malik4. 1. Department of Obstetric and Gynaecology, Pt. B. D. Sharma, PGIMS, Rohtak, Haryana, India. ana.chandi@gmail.com. 2. , HNo.: 957, sector 25, Panchkula, 134109, Haryana, India. ana.chandi@gmail.com. 3. Department of Obstetric and Gynaecology, Pt. B. D. Sharma, PGIMS, Rohtak, Haryana, India. drdayasri@yahoo.com. 4. Department of Obstetric and Gynaecology, Pt. B. D. Sharma, PGIMS, Rohtak, Haryana, India. drroopa.sangwan@gmail.com.
Abstract
BACKGROUND: Hypertensive diseases are directly responsible for 24 % of maternal deaths in India. A screening method is yet to be discovered to reduce the morbidity and mortality related to it. Serum triglyceride (TG) levels are reported to increase in hypertensive pregnant women. AIM: To predict pregnancy-induced hypertension (PIH) by serum triglyceride values. METHOD: This study is a prospective cohort study that was conducted over three hundred normotensive, primigravida women with singleton pregnancy at 14-20 weeks of gestation. These were divided into two groups on the basis of their TG concentration estimated at 14-20 weeks of gestation. The pregnancy was then followed till delivery and, signs and symptoms of PIH were noted in both the groups. RESULTS: Out of 300 women, 210 women completed the study. Fifty-nine women developed PIH and 151 women remained normotensive. Among 59 women, 45 women had raised TG values i.e., ≥160 mg/dL and 14 women were with normal TG levels i.e., <160 mg/dL. A significant positive correlation was found between serum TG concentration and systolic and diastolic blood pressure. It was observed that a cutoff of 162.50 mg/dL for TG could reliably predict PIH with sensitivity of 76 % and specificity of 85 %. Also, the mothers with hypertriglyceridemia were found to be at higher risk of developing early-onset PIH. CONCLUSION: Our study supports the evidence that early pregnancy hypertriglyceridemia is associated with an increased risk of PIH.
BACKGROUND:Hypertensive diseases are directly responsible for 24 % of maternal deaths in India. A screening method is yet to be discovered to reduce the morbidity and mortality related to it. Serum triglyceride (TG) levels are reported to increase in hypertensive pregnant women. AIM: To predict pregnancy-induced hypertension (PIH) by serum triglyceride values. METHOD: This study is a prospective cohort study that was conducted over three hundred normotensive, primigravida women with singleton pregnancy at 14-20 weeks of gestation. These were divided into two groups on the basis of their TG concentration estimated at 14-20 weeks of gestation. The pregnancy was then followed till delivery and, signs and symptoms of PIH were noted in both the groups. RESULTS: Out of 300 women, 210 women completed the study. Fifty-nine women developed PIH and 151 women remained normotensive. Among 59 women, 45 women had raised TG values i.e., ≥160 mg/dL and 14 women were with normal TG levels i.e., <160 mg/dL. A significant positive correlation was found between serum TG concentration and systolic and diastolic blood pressure. It was observed that a cutoff of 162.50 mg/dL for TG could reliably predict PIH with sensitivity of 76 % and specificity of 85 %. Also, the mothers with hypertriglyceridemia were found to be at higher risk of developing early-onset PIH. CONCLUSION: Our study supports the evidence that early pregnancy hypertriglyceridemia is associated with an increased risk of PIH.
Entities:
Keywords:
Early pregnancy; Hypertensive disorder of pregnancy; Hypertriglyceridemia; Pregnancy induced hypertension; Serum triglyceride level
Authors: Jorge Lopez-Tello; Maria Arias-Alvarez; Maria Angeles Jimenez-Martinez; Rosa Maria Garcia-Garcia; Maria Rodriguez; Pedro Luis Lorenzo Gonzalez; Ruben Bermejo-Poza; Antonio Gonzalez-Bulnes; Pilar Garcia Rebollar Journal: PLoS One Date: 2017-01-03 Impact factor: 3.240