Literature DB >> 25854922

Antibiotic-free selection in biotherapeutics: now and forever.

Charlotte Mignon1, Régis Sodoyer2, Bettina Werle3.   

Abstract

The continuously improving sophistication of molecular engineering techniques gives access to novel classes of bio-therapeutics and new challenges for their production in full respect of the strengthening regulations. Among these biologic agents are DNA based vaccines or gene therapy products and to a lesser extent genetically engineered live vaccines or delivery vehicles. The use of antibiotic-based selection, frequently associated with genetic manipulation of microorganism is currently undergoing a profound metamorphosis with the implementation and diversification of alternative selection means. This short review will present examples of alternatives to antibiotic selection and their context of application to highlight their ineluctable invasion of the bio-therapeutic world.

Entities:  

Year:  2015        PMID： 25854922      PMCID： PMC4493468          DOI： 10.3390/pathogens4020157

Source DB:  PubMed          Journal:  Pathogens        ISSN： 2076-0817


  108 in total

1.  Metabolic and translational efficiency in microbial organisms.

Authors:  Douglas W Raiford; Esley M Heizer; Robert V Miller; Travis E Doom; Michael L Raymer; Dan E Krane
Journal:  J Mol Evol       Date:  2012-04-27       Impact factor: 2.395

2.  A new DNA vehicle for nonviral gene delivery: supercoiled minicircle.

Authors:  A M Darquet; B Cameron; P Wils; D Scherman; J Crouzet
Journal:  Gene Ther       Date:  1997-12       Impact factor: 5.250

Review 3.  Antibiotics: the changing regulatory and pharmaceutical industry paradigm.

Authors:  Richard Bax; Samantha Green
Journal:  J Antimicrob Chemother       Date:  2015-01-28       Impact factor: 5.790

4.  Development of antibiotic-free selection system for safer DNA vaccination.

Authors:  Jeremy M Luke; Aaron E Carnes; James A Williams
Journal:  Methods Mol Biol       Date:  2014

5.  pFARs, plasmids free of antibiotic resistance markers, display high-level transgene expression in muscle, skin and tumour cells.

Authors:  Corinne Marie; Gaëlle Vandermeulen; Mickaël Quiviger; Magali Richard; Véronique Préat; Daniel Scherman
Journal:  J Gene Med       Date:  2010-04       Impact factor: 4.565

6.  Effect of triclosan on reproduction, DNA damage and heat shock protein gene expression of the earthworm Eisenia fetida.

Authors:  Dasong Lin; Ye Li; Qixing Zhou; Yingming Xu; Di Wang
Journal:  Ecotoxicology       Date:  2014-08-19       Impact factor: 2.823

7.  Oral delivery of a DNA vaccine against tuberculosis using operator-repressor titration in a Salmonella enterica vector.

Authors:  Jen-Min Huang; Michela Sali; Matthew W Leckenby; David S Radford; Hong A Huynh; Giovanni Delogu; Rocky M Cranenburgh; Simon M Cutting
Journal:  Vaccine       Date:  2010-09-17       Impact factor: 3.641

8.  Development of a DeltaglnA balanced lethal plasmid system for expression of heterologous antigens by attenuated vaccine vector strains of Vibrio cholerae.

Authors:  E T Ryan; T I Crean; S K Kochi; M John; A A Luciano; K P Killeen; K E Klose; S B Calderwood
Journal:  Infect Immun       Date:  2000-01       Impact factor: 3.441

9.  Plasmid-free T7-based Escherichia coli expression systems.

Authors:  Gerald Striedner; Irene Pfaffenzeller; Luchner Markus; Sabine Nemecek; Reingard Grabherr; Karl Bayer
Journal:  Biotechnol Bioeng       Date:  2010-03-01       Impact factor: 4.530

10.  Construction of Escherichia coli strains with chromosomally integrated expression cassettes for the synthesis of 2'-fucosyllactose.

Authors:  Florian Baumgärtner; Lyudmila Seitz; Georg A Sprenger; Christoph Albermann
Journal:  Microb Cell Fact       Date:  2013-05-01       Impact factor: 5.328
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  21 in total

Review 1.  Tumour-targeting bacteria engineered to fight cancer.

Authors:  Shibin Zhou; Claudia Gravekamp; David Bermudes; Ke Liu
Journal:  Nat Rev Cancer       Date:  2018-12       Impact factor: 60.716

Review 2.  Non-conventional expression systems for the production of vaccine proteins and immunotherapeutic molecules.

Authors:  Isabelle Legastelois; Sophie Buffin; Isabelle Peubez; Charlotte Mignon; Régis Sodoyer; Bettina Werle
Journal:  Hum Vaccin Immunother       Date:  2016-12-01       Impact factor: 3.452

3.  Complementation of Arginine Auxotrophy for Genetic Transformation of Coxiella burnetii by Use of a Defined Axenic Medium.

Authors:  Kelsi M Sandoz; Paul A Beare; Diane C Cockrell; Robert A Heinzen
Journal:  Appl Environ Microbiol       Date:  2016-05-02       Impact factor: 4.792

4.  Molecular Cloning, Structural Modeling and the Production of Soluble Triple-Mutated Diphtheria Toxoid (K51E/G52E/E148K) Co-expressed with Molecular Chaperones in Recombinant Escherichia coli.

Authors:  Naphatsamon Uthailak; Pornpimol Mahamad; Pamorn Chittavanich; Somchai Yanarojana; Wassana Wijagkanalan; Jean Petre; Watanalai Panbangred
Journal:  Mol Biotechnol       Date:  2017-05       Impact factor: 2.695

5.  Process intensification at the expression system level for the production of 1-phosphate aldolase in antibiotic-free E. coli fed-batch cultures.

Authors:  Martina Pasini; Alfred Fernández-Castané; Gloria Caminal; Tim W Overton; Pau Ferrer
Journal:  J Ind Microbiol Biotechnol       Date:  2022-07-30       Impact factor: 4.258

6.  Xer recombination for the automatic deletion of selectable marker genes from plasmids in enteric bacteria.

Authors:  Paola Salerno; Matthew W Leckenby; Bruce Humphrey; Rocky M Cranenburgh
Journal:  Synth Biol (Oxf)       Date:  2022-05-13

7.  Establishment of a yeast-based VLP platform for antigen presentation.

Authors:  David Wetzel; Theresa Rolf; Manfred Suckow; Andreas Kranz; Andreas Barbian; Jo-Anne Chan; Joachim Leitsch; Michael Weniger; Volker Jenzelewski; Betty Kouskousis; Catherine Palmer; James G Beeson; Gerhard Schembecker; Juliane Merz; Michael Piontek
Journal:  Microb Cell Fact       Date:  2018-02-05       Impact factor: 5.328

8.  A Novel Nonantibiotic, lgt-Based Selection System for Stable Maintenance of Expression Vectors in Escherichia coli and Vibrio cholerae.

Authors:  Manuela Terrinoni; Stefan L Nordqvist; Susanne Källgård; Jan Holmgren; Michael Lebens
Journal:  Appl Environ Microbiol       Date:  2018-01-31       Impact factor: 4.792

9.  Clinically Usable Interleukin 12 Plasmid without an Antibiotic Resistance Gene: Functionality and Toxicity Study in Murine Melanoma Model.

Authors:  Urska Kamensek; Natasa Tesic; Gregor Sersa; Maja Cemazar
Journal:  Cancers (Basel)       Date:  2018-02-27       Impact factor: 6.639

10.  'Deadman' and 'Passcode' microbial kill switches for bacterial containment.

Authors:  Clement T Y Chan; Jeong Wook Lee; D Ewen Cameron; Caleb J Bashor; James J Collins
Journal:  Nat Chem Biol       Date:  2015-12-07       Impact factor: 15.040
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