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Literature DB >> 25854913

Hepatic lipid droplet biology: Getting to the root of fatty liver.

Douglas G Mashek¹, Salmaan A Khan¹, Aishwarya Sathyanarayan¹, Jonathan M Ploeger¹, Mallory P Franklin¹.

Abstract

Hepatic steatosis is defined by the accumulation of lipid droplets (LDs). Once thought to be only inert energy storage depots, LDs are increasingly recognized as organelles that have important functions in hepatocytes beyond lipid storage. The lipid and protein composition of LDs is highly dynamic and influences their intrinsic metabolism and signaling properties, which ultimately links them to the changes in hepatic function. This concise review highlights recent discoveries in LD biology and unique aspects of hepatic LDs and their role in liver disease.

Entities: Chemical Disease Gene Mutation Species

Mesh：

Year: 2015 PMID： 25854913 PMCID： PMC4549163 DOI： 10.1002/hep.27839

Source DB: PubMed Journal: Hepatology ISSN： 0270-9139 Impact factor: 17.425

43 in total

1. Opposing roles of cell death-inducing DFF45-like effector B and perilipin 2 in controlling hepatic VLDL lipidation.

Authors: Xuanhe Li; Jing Ye; Linkang Zhou; Wei Gu; Edward A Fisher; Peng Li
Journal: J Lipid Res Date: 2012-06-01 Impact factor: 5.922

2. The small GTPase Rab7 as a central regulator of hepatocellular lipophagy.

Authors: Barbara Schroeder; Ryan J Schulze; Shaun G Weller; Arthur C Sletten; Carol A Casey; Mark A McNiven
Journal: Hepatology Date: 2015-04-23 Impact factor: 17.425

3. Liver specific inactivation of carboxylesterase 3/triacylglycerol hydrolase decreases blood lipids without causing severe steatosis in mice.

Authors: Jihong Lian; Enhui Wei; Shu Pei Wang; Ariel D Quiroga; Lena Li; Alba Di Pardo; Jelske van der Veen; Simonetta Sipione; Grant A Mitchell; Richard Lehner
Journal: Hepatology Date: 2012-12 Impact factor: 17.425

4. Fat-specific protein 27 modulates nuclear factor of activated T cells 5 and the cellular response to stress.

Authors: Masami Ueno; Wen-Jun Shen; Shailja Patel; Andrew S Greenberg; Salman Azhar; Fredric B Kraemer
Journal: J Lipid Res Date: 2012-12-11 Impact factor: 5.922

5. Synergistic interaction of dietary cholesterol and dietary fat in inducing experimental steatohepatitis.

Authors: Christopher Savard; Erica V Tartaglione; Rahul Kuver; W Geoffrey Haigh; Geoffrey C Farrell; Savitha Subramanian; Alan Chait; Matthew M Yeh; Lebris S Quinn; George N Ioannou
Journal: Hepatology Date: 2013-01 Impact factor: 17.425

6. Cholesterol-lowering drugs cause dissolution of cholesterol crystals and disperse Kupffer cell crown-like structures during resolution of NASH.

Authors: George N Ioannou; Derrick M Van Rooyen; Christopher Savard; W Geoffrey Haigh; Matthew M Yeh; Narci C Teoh; Geoffrey C Farrell
Journal: J Lipid Res Date: 2014-12-17 Impact factor: 5.922

7. Perilipin 5 improves hepatic lipotoxicity by inhibiting lipolysis.

Authors: Chao Wang; Yuanlin Zhao; Xing Gao; Le Li; Yuan Yuan; Fang Liu; Lijun Zhang; Jie Wu; Peizhen Hu; Xiumin Zhang; Yu Gu; Yuqiao Xu; Zhe Wang; Zengshan Li; Huizhong Zhang; Jing Ye
Journal: Hepatology Date: 2015-01-28 Impact factor: 17.425

8. Hepatic lipid droplets. Isolation, morphology and composition.

Authors: R P DiAugustine; J M Schaefer; J R Fouts
Journal: Biochem J Date: 1973-02 Impact factor: 3.857

9. ATGL-catalyzed lipolysis regulates SIRT1 to control PGC-1α/PPAR-α signaling.

Authors: Salmaan Ahmed Khan; Aishwarya Sathyanarayan; Mara T Mashek; Kuok Teong Ong; Edith E Wollaston-Hayden; Douglas G Mashek
Journal: Diabetes Date: 2015-02 Impact factor: 9.461

10. Pnpla3I148M knockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis.

Authors: Eriks Smagris; Soumik BasuRay; John Li; Yongcheng Huang; Ka-man V Lai; Jesper Gromada; Jonathan C Cohen; Helen H Hobbs
Journal: Hepatology Date: 2014-10-01 Impact factor: 17.425

37 in total

1. Lipid droplet quantification based on iterative image processing.

Authors: Tarik Exner; Carlo A Beretta; Qi Gao; Cassian Afting; Inés Romero-Brey; Ralf Bartenschlager; Leonard Fehring; Margarete Poppelreuther; Joachim Füllekrug
Journal: J Lipid Res Date: 2019-03-29 Impact factor: 5.922

2. Lipid droplet-associated kinase STK25 regulates peroxisomal activity and metabolic stress response in steatotic liver.

Authors: Annika Nerstedt; Yeshwant Kurhe; Emmelie Cansby; Mara Caputo; Lei Gao; Egor Vorontsov; Marcus Ståhlman; Esther Nuñez-Durán; Jan Borén; Hanns-Ulrich Marschall; Douglas G Mashek; Darren N Saunders; Carina Sihlbom; Andrew J Hoy; Margit Mahlapuu
Journal: J Lipid Res Date: 2019-12-19 Impact factor: 5.922

Review 3. Pathophysiology of lipid droplet proteins in liver diseases.

Authors: Rotonya M Carr; Rexford S Ahima
Journal: Exp Cell Res Date: 2015-10-26 Impact factor: 3.905

4. Triacsin C reduces lipid droplet formation and induces mitochondrial biogenesis in primary rat hepatocytes.

Authors: Carlos R P Dechandt; Felippe H Zuccolotto-Dos-Reis; Bruno G Teodoro; Anna Maria A P Fernandes; Marcos N Eberlin; Isis C Kettelhut; Carlos Curti; Luciane C Alberici
Journal: J Bioenerg Biomembr Date: 2017-09-16 Impact factor: 2.945

5. Hepatic PLIN5 signals via SIRT1 to promote autophagy and prevent inflammation during fasting.

Authors: Enxiang Zhang; Wenqi Cui; Michael Lopresti; Mara T Mashek; Charles P Najt; Hongbo Hu; Douglas G Mashek
Journal: J Lipid Res Date: 2020-01-13 Impact factor: 5.922

6. The α' subunit of β-conglycinin and various glycinin subunits of soy are not required to modulate hepatic lipid metabolism in rats.

Authors: Cynthia Chatterjee; Jiajie Liu; Carla Wood; Christine Gagnon; Elroy R Cober; Judith A Frégeau-Reid; Stephen Gleddie; Chao-Wu Xiao
Journal: Eur J Nutr Date: 2017-03-21 Impact factor: 5.614