AIMS: An abnormal activity in the electroencephalography (EEG) gamma band (>30 Hz) has been demonstrated in schizophrenia and this has been suggested to be reflecting a deficit in the development and maturation of the basic cognitive functions of attention, working memory and sensory processing. Hypothesizing gamma oscillatory activity as a potential EEG biomarker to antipsychotic response in schizophrenia, the present study aimed at measuring baseline spontaneous gamma activity in schizophrenia patients, and evaluating its response to antipsychotic treatment over 8 weeks. METHODS: Fifteen drug-free/naïve patients were recruited, compared at baseline with 15 age-, sex- and education-matched healthy controls, and were followed up for 8 weeks' treatment on antipsychotics. Resting state EEG waves were recorded using high (192-channel) resolution EEG at admission, 4 weeks and 8 weeks. Spectral power was calculated using fast Fourier transformation, Hanning window. The power was averaged region-wise over nine regions in three frequency ranges (30-50 Hz, 50-70 Hz, 70-100 Hz). RESULTS: Patients and controls differed significantly at intake in terms of left temporal and parietal high (70-100 Hz) gamma power. Consequently, no significant differences were seen over the course of antipsychotic treatment on gamma spectral power in any of the regions. CONCLUSIONS: Lack of significant effect of treatment on gamma power suggests that these gamma oscillations may be trait markers in schizophrenia.
AIMS: An abnormal activity in the electroencephalography (EEG) gamma band (>30 Hz) has been demonstrated in schizophrenia and this has been suggested to be reflecting a deficit in the development and maturation of the basic cognitive functions of attention, working memory and sensory processing. Hypothesizing gamma oscillatory activity as a potential EEG biomarker to antipsychotic response in schizophrenia, the present study aimed at measuring baseline spontaneous gamma activity in schizophreniapatients, and evaluating its response to antipsychotic treatment over 8 weeks. METHODS: Fifteen drug-free/naïve patients were recruited, compared at baseline with 15 age-, sex- and education-matched healthy controls, and were followed up for 8 weeks' treatment on antipsychotics. Resting state EEG waves were recorded using high (192-channel) resolution EEG at admission, 4 weeks and 8 weeks. Spectral power was calculated using fast Fourier transformation, Hanning window. The power was averaged region-wise over nine regions in three frequency ranges (30-50 Hz, 50-70 Hz, 70-100 Hz). RESULTS:Patients and controls differed significantly at intake in terms of left temporal and parietal high (70-100 Hz) gamma power. Consequently, no significant differences were seen over the course of antipsychotic treatment on gamma spectral power in any of the regions. CONCLUSIONS: Lack of significant effect of treatment on gamma power suggests that these gamma oscillations may be trait markers in schizophrenia.
Authors: Jeyeon Lee; Hoseok Choi; Seho Lee; Baek Hwan Cho; Kyoung Ha Ahn; In Young Kim; Kyoung Min Lee; Dong Pyo Jang Journal: J Korean Med Sci Date: 2017-08 Impact factor: 2.153
Authors: Lauren E Ethridge; Stormi P White; Matthew W Mosconi; Jun Wang; Ernest V Pedapati; Craig A Erickson; Matthew J Byerly; John A Sweeney Journal: Mol Autism Date: 2017-06-07 Impact factor: 7.509
Authors: Lauren E Ethridge; Lisa A De Stefano; Lauren M Schmitt; Nicholas E Woodruff; Kara L Brown; Morgan Tran; Jun Wang; Ernest V Pedapati; Craig A Erickson; John A Sweeney Journal: Front Integr Neurosci Date: 2019-10-09