Literature DB >> 2585403

Cell wall fragments from major residents of the human intestinal flora induce chronic arthritis in rats.

A J Severijnen1, R van Kleef, M P Hazenberg, J P van de Merwe.   

Abstract

To investigate the involvement of human intestinal flora in joint inflammation, cell wall fragments of 9 anaerobic gram positive bacteria of the human fecal flora were prepared and tested for arthropathic properties in the rat. A single intraperitoneal injection of cell wall fragments from Eubacterium aerofaciens or Bifidobacterium species induced persistent chronic arthritis, in contrast to those from Eubacterium rectale, Clostridium species and Lactobacillus leichmanii. The results show that cell wall fragments of major residents from the human fecal flora can induce chronic arthritis in the rat and support the hypothesis that normal human intestinal flora plays a role in the induction of arthritis in man.

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Year:  1989        PMID： 2585403

Source DB:  PubMed          Journal:  J Rheumatol        ISSN： 0315-162X            Impact factor:   4.666


  20 in total

Review 1.  Normal intestinal microbiota in the aetiopathogenesis of rheumatoid arthritis.

Authors:  P Toivanen
Journal:  Ann Rheum Dis       Date:  2003-09       Impact factor: 19.103

2.  Influence of decontamination on induction of arthritis in Lewis rats by cell wall fragments of Eubacterium aerofaciens. Arthropathic properties of indigenous anaerobic bacteria.

Authors:  J Kool; A J Severijnen; I S Klasen; M Y Gerrits-Boeye; M P Hazenberg
Journal:  Ann Rheum Dis       Date:  1992-04       Impact factor: 19.103

3.  Normal luminal bacteria, especially Bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLA-B27/human beta2 microglobulin transgenic rats.

Authors:  H C Rath; H H Herfarth; J S Ikeda; W B Grenther; T E Hamm; E Balish; J D Taurog; R E Hammer; K H Wilson; R B Sartor
Journal:  J Clin Invest       Date:  1996-08-15       Impact factor: 14.808

4.  Reduced systemic IgG levels against peptidoglycan in rheumatoid arthritis (RA) patients.

Authors:  I A Schrijver; Y A De Man; M J Melief; J M Van Laar; H M Markusse; I S Klasen; M P Hazenberg; J D Laman
Journal:  Clin Exp Immunol       Date:  2001-01       Impact factor: 4.330

5.  Muramic acid is not generally present in the human spleen as determined by gas chromatography-tandem mass spectrometry.

Authors:  Michael P Kozar; Jon D Laman; Alvin Fox
Journal:  Infect Immun       Date:  2002-02       Impact factor: 3.441

6.  Role of peptidoglycan subtypes in the pathogenesis of bacterial cell wall arthritis.

Authors:  E Simelyte; M Rimpiläinen; X Zhang; P Toivanen
Journal:  Ann Rheum Dis       Date:  2003-10       Impact factor: 19.103

7.  Experimental immune mediated arthritis in rhesus monkeys. A model for human rheumatoid arthritis?

Authors:  N P Bakker; M G van Erck; C Zurcher; P Faaber; A Lemmens; M Hazenberg; R E Bontrop; M Jonker
Journal:  Rheumatol Int       Date:  1990       Impact factor: 2.631

8.  Induction of intestinal Th17 cells by segmented filamentous bacteria.

Authors:  Ivaylo I Ivanov; Koji Atarashi; Nicolas Manel; Eoin L Brodie; Tatsuichiro Shima; Ulas Karaoz; Dongguang Wei; Katherine C Goldfarb; Clark A Santee; Susan V Lynch; Takeshi Tanoue; Akemi Imaoka; Kikuji Itoh; Kiyoshi Takeda; Yoshinori Umesaki; Kenya Honda; Dan R Littman
Journal:  Cell       Date:  2009-10-30       Impact factor: 41.582

9.  Histology of joint inflammation induced in rats by cell wall fragments of the anaerobic intestinal bacterium Eubacterium aerofaciens.

Authors:  A J Severijnen; R van Kleef; A A Grandia; T H van der Kwast; M P Hazenberg
Journal:  Rheumatol Int       Date:  1991       Impact factor: 2.631

10.  Chronic arthritis induced in rats by cell wall fragments of Eubacterium species from the human intestinal flora.

Authors:  A J Severijnen; R van Kleef; M P Hazenberg; J P van de Merwe
Journal:  Infect Immun       Date:  1990-02       Impact factor: 3.441
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