| Literature DB >> 25853994 |
Cassandra L Fleming1, Trent D Ashton, Cameron Nowell, Mark Devlin, Anthony Natoli, Jeannette Schreuders, Frederick M Pfeffer.
Abstract
Fluorescence microscopy studies using 4-morpholinoscriptaid (4MS) demonstrated rapid cellular uptake of this scriptaid analogue into the cytoplasm but no nuclear penetration. As 4MS and scriptaid have the same in vitro activity against HDACs and KASUMI-1 cells; 4MS exemplifies a rational approach to subtly modify ‘profluorogenic’ substrates for intracellular studies.Entities:
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Year: 2015 PMID： 25853994 DOI： 10.1039/c5cc02059j
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222