Literature DB >> 25853082

The effects of antiepileptic drugs on cognitive functional magnetic resonance imaging.

Guilherme Coco Beltramini1, Fernando Cendes1, Clarissa Lin Yasuda1.   

Abstract

The cognitive dysfunction caused by antiepileptic drugs (AEDs) has been extensively described, although the mechanisms underlying such collateral effects are still poorly understood. The combination of functional magnetic resonance imaging (fMRI) studies with pharmacological intervention (pharmaco-MRI or ph-MRI) offers the opportunity to investigate the effect of drugs such as AEDs on brain activity, including cognitive tasks. Here we review the studies that investigated the effects of AEDs [topiramate (TPM), lamotrigine (LMT), carbamazepine (CBZ), pregabalin (PGB), valproate (VPA) and levetiracetam (LEV)] on cognitive fMRI tasks. Despite the scarcity of fMRI studies focusing on the impact of AEDs on cognitive task, the results of recent work have provided important information about specific drug-related changes of brain function.

Entities:  

Keywords:  Antiepileptic drugs (AEDs); cognitive functional magnetic resonance imaging (fMRI)

Year:  2015        PMID: 25853082      PMCID: PMC4379315          DOI: 10.3978/j.issn.2223-4292.2015.01.04

Source DB:  PubMed          Journal:  Quant Imaging Med Surg        ISSN: 2223-4306


  51 in total

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Review 6.  Pharmaco-fMRI: A Tool to Predict the Response to Antiepileptic Drugs in Epilepsy.

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9.  Understanding the Cognitive Side Effects of Antiepileptic Drugs: Can Functional Imaging Be Helpful?

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  9 in total

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