Pradeep D Chaudhary1, Sanjay Rastogi2, Prashant Gupta3, B Niranjanaprasad Indra2, Roy Thomas4, Rupshikha Choudhury5. 1. Professor, Department of Conservative and Endodontics, Bhartiya Vidyapeeth Dental College, Pune, Maharashtra, India. 2. Reader, Department of Oral and Maxillofacial Surgery, Institute of Dental Science - Bareilly, Uttar Pradesh, India. 3. Reader, Department of Oral and Maxillofacial Surgery, Private Practice, Uttar Pradesh, India. 4. Professor and Consultant, Oral and Maxillofacial Surgery, Private Practice, Kerala, India. 5. Post Graduate Student, Department of Oral and Maxillofacial Surgery, ITS - Centre for Dental Studies and Research, Murad Nagar, Ghaziabad, Uttar Pradesh, India.
Abstract
AIM: To evaluate the preventative effect of intravenous 4 mg of dexamethasone and 8 mg oral dexamethasone on post-operative pain, swelling and trismus after the surgical extraction of mandibular third molars. MATERIALS AND METHODS: A randomized clinical trial comprised of 200 patients (control group I intravenous and experimental group II orally) with impacted lower third molars, average age 20.8 years with no local or systemic problems, with bilateral impacted lower third molars, were operated under local anesthesia. Group I was given 4 mg IV and group II was given 8 mg orally of dexamethasone 1 h before procedure. The choice of which side to operate first and the amount of concentration of medication to use was made randomly and double-blindly. Post-operative pain was evaluated using a visual analog scale (VAS) and the degree of swelling was evaluated through facial reference points' variation. The presence of trismus was analyzed through measurement of the interincisal distance (IID). These assessments were obtained before the operation and 24 h, 48 h and 7th POD. RESULTS: No significant difference was found in facial swelling and trismus between IV 4 mg injection and oral 8 mg consumption after lower third molar surgery (student t test P > 0.05). The visual analogue scale scores for pain assessment showed no significant difference between IV injection and oral route of dexamethasone (student t test P > 0.05). CONCLUSION: Patients can be administered 8 mg oral dexamethasone is as effective as 4 mg intra venous route without much difference in final outcome at any given point of time.
RCT Entities:
AIM: To evaluate the preventative effect of intravenous 4 mg of dexamethasone and 8 mg oral dexamethasone on post-operative pain, swelling and trismus after the surgical extraction of mandibular third molars. MATERIALS AND METHODS: A randomized clinical trial comprised of 200 patients (control group I intravenous and experimental group II orally) with impacted lower third molars, average age 20.8 years with no local or systemic problems, with bilateral impacted lower third molars, were operated under local anesthesia. Group I was given 4 mg IV and group II was given 8 mg orally of dexamethasone 1 h before procedure. The choice of which side to operate first and the amount of concentration of medication to use was made randomly and double-blindly. Post-operative pain was evaluated using a visual analog scale (VAS) and the degree of swelling was evaluated through facial reference points' variation. The presence of trismus was analyzed through measurement of the interincisal distance (IID). These assessments were obtained before the operation and 24 h, 48 h and 7th POD. RESULTS: No significant difference was found in facial swelling and trismus between IV 4 mg injection and oral 8 mg consumption after lower third molar surgery (student t test P > 0.05). The visual analogue scale scores for pain assessment showed no significant difference between IV injection and oral route of dexamethasone (student t test P > 0.05). CONCLUSION:Patients can be administered 8 mg oral dexamethasone is as effective as 4 mg intra venous route without much difference in final outcome at any given point of time.
Entities:
Keywords:
Dexamethasone; Impacted mandibular third molar; Pain; Swelling; Trismus
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