Literature DB >> 25849904

Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter.

John L Wallace1, Rui Wang2.   

Abstract

Hydrogen sulfide (H2S) has become recognized as an important signalling molecule throughout the body, contributing to many physiological and pathological processes. In recent years, improved methods for measuring H2S levels and the availability of a wider range of H2S donors and more selective inhibitors of H2S synthesis have helped to more accurately identify the many biological effects of this highly reactive gaseous mediator. Animal studies of several H2S-releasing drugs have demonstrated considerable promise for the safe treatment of a wide range of disorders. Several such drugs are now in clinical trials.

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Year:  2015        PMID： 25849904     DOI： 10.1038/nrd4433

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN： 1474-1776            Impact factor:   84.694


  189 in total

1.  Free and acid-labile hydrogen sulfide concentrations in mouse tissues: anomalously high free hydrogen sulfide in aortic tissue.

Authors:  Michael D Levitt; Mohamed Saber Abdel-Rehim; Julie Furne
Journal:  Antioxid Redox Signal       Date:  2011-02-03       Impact factor: 8.401

2.  Hydrogen sulfide-linked sulfhydration of NF-κB mediates its antiapoptotic actions.

Authors:  Nilkantha Sen; Bindu D Paul; Moataz M Gadalla; Asif K Mustafa; Tanusree Sen; Risheng Xu; Seyun Kim; Solomon H Snyder
Journal:  Mol Cell       Date:  2012-01-13       Impact factor: 17.970

3.  5-Amino-2-hydroxybenzoic acid 4-(5-thioxo-5H-[1,2]dithiol-3yl)-phenyl ester (ATB-429), a hydrogen sulfide-releasing derivative of mesalamine, exerts antinociceptive effects in a model of postinflammatory hypersensitivity.

Authors:  Eleonora Distrutti; Luca Sediari; Andrea Mencarelli; Barbara Renga; Stefano Orlandi; Giuseppe Russo; Giuseppe Caliendo; Vincenzo Santagada; Giuseppe Cirino; John L Wallace; Stefano Fiorucci
Journal:  J Pharmacol Exp Ther       Date:  2006-07-19       Impact factor: 4.030

4.  Oxygen-sensitive mitochondrial accumulation of cystathionine β-synthase mediated by Lon protease.

Authors:  Huajian Teng; Bo Wu; Kexin Zhao; Guangdong Yang; Lingyun Wu; Rui Wang
Journal:  Proc Natl Acad Sci U S A       Date:  2013-07-15       Impact factor: 11.205

5.  Hydrogen sulfide protects from colitis and restores intestinal microbiota biofilm and mucus production.

Authors:  Jean-Paul Motta; Kyle L Flannigan; Terence A Agbor; Jennifer K Beatty; Rory W Blackler; Matthew L Workentine; Gabriela J Da Silva; Rui Wang; Andre G Buret; John L Wallace
Journal:  Inflamm Bowel Dis       Date:  2015-05       Impact factor: 5.325

6.  Is cystathionine gamma-lyase protein expressed in the heart?

Authors:  Ming Fu; Weihua Zhang; Guangdong Yang; Rui Wang
Journal:  Biochem Biophys Res Commun       Date:  2012-10-30       Impact factor: 3.575

7.  Sulphide impairment of substrate oxidation in rat colonocytes: a biochemical basis for ulcerative colitis?

Authors:  W E Roediger; A Duncan; O Kapaniris; S Millard
Journal:  Clin Sci (Lond)       Date:  1993-11       Impact factor: 6.124

8.  Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of angiogenesis and endothelium-dependent vasorelaxation.

Authors:  Ciro Coletta; Andreas Papapetropoulos; Katalin Erdelyi; Gabor Olah; Katalin Módis; Panagiotis Panopoulos; Antonia Asimakopoulou; Domokos Gerö; Iraida Sharina; Emil Martin; Csaba Szabo
Journal:  Proc Natl Acad Sci U S A       Date:  2012-05-08       Impact factor: 11.205

9.  Plasma free H2S levels are elevated in patients with cardiovascular disease.

Authors:  Elvis A Peter; Xinggui Shen; Shivang H Shah; Sibile Pardue; John D Glawe; Wayne W Zhang; Pratap Reddy; Nuri I Akkus; Jai Varma; Christopher G Kevil
Journal:  J Am Heart Assoc       Date:  2013-10-23       Impact factor: 5.501

10.  Cytoprotective effects of hydrogen sulfide in novel rat models of non-erosive esophagitis.

Authors:  Oksana Zayachkivska; Olena Havryluk; Nazar Hrycevych; Nazar Bula; Oksana Grushka; John L Wallace
Journal:  PLoS One       Date:  2014-10-21       Impact factor: 3.240
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  220 in total

1.  H2S confers colonoprotection against TNBS-induced colitis by HO-1 upregulation in rats.

Authors:  Krisztina Kupai; Nikoletta Almási; Magdolna Kósa; János Nemcsók; Zsolt Murlasits; Szilvia Török; Amin Al-Awar; Zoltán Baráth; Anikó Pósa; Csaba Varga
Journal:  Inflammopharmacology       Date:  2017-08-02       Impact factor: 4.473

2.  Hydrogen sulfide and PKG in ischemia-reperfusion injury: sources, signaling, accelerators and brakes.

Authors:  Ioanna Andreadou; Efstathios K Iliodromitis; Csaba Szabo; Andreas Papapetropoulos
Journal:  Basic Res Cardiol       Date:  2015-08-30       Impact factor: 17.165

Review 3.  The role of the gasotransmitter hydrogen sulfide in pathological calcification.

Authors:  Mariela Castelblanco; Sonia Nasi; Andreas Pasch; Alexander So; Nathalie Busso
Journal:  Br J Pharmacol       Date:  2019-07-24       Impact factor: 8.739

Review 4.  Vascular biology of hydrogen sulfide.

Authors:  Nancy L Kanagy; Csaba Szabo; Andreas Papapetropoulos
Journal:  Am J Physiol Cell Physiol       Date:  2017-02-01       Impact factor: 4.249

5.  Synthesis of multi-omic data and community metabolic models reveals insights into the role of hydrogen sulfide in colon cancer.

Authors:  Vanessa L Hale; Patricio Jeraldo; Michael Mundy; Janet Yao; Gary Keeney; Nancy Scott; E Heidi Cheek; Jennifer Davidson; Megan Greene; Christine Martinez; John Lehman; Chandra Pettry; Erica Reed; Kelly Lyke; Bryan A White; Christian Diener; Osbaldo Resendis-Antonio; Jaime Gransee; Tumpa Dutta; Xuan-Mai Petterson; Lisa Boardman; David Larson; Heidi Nelson; Nicholas Chia
Journal:  Methods       Date:  2018-04-26       Impact factor: 3.608

Review 6.  The dichotomous role of H2S in cancer cell biology? Déjà vu all over again.

Authors:  Khosrow Kashfi
Journal:  Biochem Pharmacol       Date:  2018-02-14       Impact factor: 5.858

Review 7.  Protein S-sulfhydration by hydrogen sulfide in cardiovascular system.

Authors:  Guoliang Meng; Shuang Zhao; Liping Xie; Yi Han; Yong Ji
Journal:  Br J Pharmacol       Date:  2017-05-24       Impact factor: 8.739

8.  Cyclic Sulfenyl Thiocarbamates Release Carbonyl Sulfide and Hydrogen Sulfide Independently in Thiol-Promoted Pathways.

Authors:  Yu Zhao; Andrea K Steiger; Michael D Pluth
Journal:  J Am Chem Soc       Date:  2019-08-14       Impact factor: 15.419

Review 9.  Cutting back on the essentials: Can manipulating intake of specific amino acids modulate health and lifespan?

Authors:  Holly M Brown-Borg; Rochelle Buffenstein
Journal:  Ageing Res Rev       Date:  2016-08-26       Impact factor: 10.895

10.  A direct and selective electrochemical hydrogen sulfide sensor.

Authors:  Micah D Brown; Jackson R Hall; Mark H Schoenfisch
Journal:  Anal Chim Acta       Date:  2018-09-01       Impact factor: 6.558
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