Megan Bollinger1, Marsha Hamilton2, Kurt Schroeder3, Sonia Link2, Jasmyn Nguyen4, Dominic Chu4, Wilma Hopman5, Raphael Saginur6, Len Kelly7. 1. Northern Ontario School of Medicine, Sioux Lookout, Ont. 2. Sioux Lookout Meno Ya Win Health Centre, Sioux Lookout, Ont. 3. Interlake Regional Health Authority, Selkirk, Man. 4. Royal College of Surgeons in Ireland, Dublin, Ireland. 5. Kingston General Hospital, and Department of Community Health and Epidemiology, Queen's University, Kingston, Ont. 6. Division of Infectious Diseases, Ottawa Hospital Research Institute, and Faculty of Medicine, University of Ottawa, Ottawa, Ont. 7. Anishinaabe Bimaadiziwin Research Program, Sioux Lookout, Ont.
Abstract
INTRODUCTION: Urban centres often perform audits of vancomycin use as they face outbreaks of resistant organisms. We undertook this study to understand the indications and duration of intravenous vancomycin in a rural setting. METHODS: We conducted a retrospective chart audit for all patients who received intravenous vancomycin over a 3-year period at a rural hospital in northwestern Ontario. RESULTS: Vancomycin was used intravenously in 180 patients during the study period. It was used for short courses (median 3 d), and serum levels were below target 72% of the time. CONCLUSION: High rates of invasive methicillin-resistant Staphylococcus aureus bacteremia and limited antibiotic choices in the field likely contributed to short courses of this antibiotic. Further study on clinical severity and antibiotic choice is needed. Additionally, weight-based dosing may result in target serum levels being achieved more frequently.
INTRODUCTION: Urban centres often perform audits of vancomycin use as they face outbreaks of resistant organisms. We undertook this study to understand the indications and duration of intravenous vancomycin in a rural setting. METHODS: We conducted a retrospective chart audit for all patients who received intravenous vancomycin over a 3-year period at a rural hospital in northwestern Ontario. RESULTS:Vancomycin was used intravenously in 180 patients during the study period. It was used for short courses (median 3 d), and serum levels were below target 72% of the time. CONCLUSION: High rates of invasive methicillin-resistant Staphylococcus aureus bacteremia and limited antibiotic choices in the field likely contributed to short courses of this antibiotic. Further study on clinical severity and antibiotic choice is needed. Additionally, weight-based dosing may result in target serum levels being achieved more frequently.
Authors: Pyoeng Gyun Choe; Hei Lim Koo; Doran Yoon; Ji Yun Bae; Eunyoung Lee; Joo-Hee Hwang; Kyoung-Ho Song; Wan Beom Park; Ji Hwan Bang; Eu Suk Kim; Hong Bin Kim; Sang Won Park; Myoung-Don Oh; Nam Joong Kim Journal: BMC Infect Dis Date: 2018-04-16 Impact factor: 3.090