Literature DB >> 25849249

CD146: the unveiling of a pro-angiogenic netrin receptor.

Brad St Croix1.   

Abstract

Netrin-1, a classic neuronal guidance cue, can promote angiogenesis under certain developmental and pathological conditions, but key receptors on vascular endothelium have remained elusive. A recent study published in Cell Research by Tu et al. reveals that CD146, an endothelial receptor of the immunoglobulin superfamily, binds netrin-1 with high affinity and may play an important role in regulating angiogenesis.

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Year:  2015        PMID： 25849249      PMCID： PMC4423082          DOI： 10.1038/cr.2015.42

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  12 in total

1.  The axonal attractant Netrin-1 is an angiogenic factor.

Authors:  Kye Won Park; Dana Crouse; Mark Lee; Satyajit K Karnik; Lise K Sorensen; Kelly J Murphy; Calvin J Kuo; Dean Y Li
Journal:  Proc Natl Acad Sci U S A       Date:  2004-11-01       Impact factor: 11.205

Review 2.  Netrin-integrin signaling in epithelial morphogenesis, axon guidance and vascular patterning.

Authors:  Sotiris N Nikolopoulos; Filippo G Giancotti
Journal:  Cell Cycle       Date:  2005-03-18       Impact factor: 4.534

3.  The crystal structure of netrin-1 in complex with DCC reveals the bifunctionality of netrin-1 as a guidance cue.

Authors:  Lorenzo I Finci; Nina Krüger; Xiaqin Sun; Jie Zhang; Magda Chegkazi; Yu Wu; Gundolf Schenk; Haydyn D T Mertens; Dmitri I Svergun; Yan Zhang; Jia-Huai Wang; Rob Meijers
Journal:  Neuron       Date:  2014-08-07       Impact factor: 17.173

4.  The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system.

Authors:  Xiaowei Lu; Ferdinand Le Noble; Li Yuan; Quingjan Jiang; Benjamin De Lafarge; Daisuke Sugiyama; Christiane Bréant; Filip Claes; Frederik De Smet; Jean-Léon Thomas; Monica Autiero; Peter Carmeliet; Marc Tessier-Lavigne; Anne Eichmann
Journal:  Nature       Date:  2004-10-27       Impact factor: 49.962

5.  A novel anti-CD146 monoclonal antibody, AA98, inhibits angiogenesis and tumor growth.

Authors:  Xiyun Yan; Yun Lin; Dongling Yang; Yi Shen; Mei Yuan; Zhiqiang Zhang; Peiyu Li; Hongtian Xia; Li Li; Dandan Luo; Qin Liu; Karlheinz Mann; Bernhard L Bader
Journal:  Blood       Date:  2003-02-27       Impact factor: 22.113

6.  Endothelial CD146 is required for in vitro tumor-induced angiogenesis: the role of a disulfide bond in signaling and dimerization.

Authors:  Chaogu Zheng; Yijun Qiu; Qiqun Zeng; Ying Zhang; Di Lu; Dongling Yang; Jing Feng; Xiyun Yan
Journal:  Int J Biochem Cell Biol       Date:  2009-04-05       Impact factor: 5.085

7.  Inhibition of endothelial cell apoptosis by netrin-1 during angiogenesis.

Authors:  Marie Castets; Marie-May Coissieux; Céline Delloye-Bourgeois; Laure Bernard; Jean-Guy Delcros; Agnès Bernet; Vincent Laudet; Patrick Mehlen
Journal:  Dev Cell       Date:  2009-04       Impact factor: 12.270

8.  Activation of the UNC5B receptor by Netrin-1 inhibits sprouting angiogenesis.

Authors:  Bruno Larrivée; Catarina Freitas; Marc Trombe; Xiang Lv; Benjamin Delafarge; Li Yuan; Karine Bouvrée; Christiane Bréant; Raquel Del Toro; Nicolas Bréchot; Stéphane Germain; Françoise Bono; Frédérique Dol; Filip Claes; Christian Fischer; Monica Autiero; Jean-Léon Thomas; Peter Carmeliet; Marc Tessier-Lavigne; Anne Eichmann
Journal:  Genes Dev       Date:  2007-10-01       Impact factor: 11.361

9.  CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development.

Authors:  Tao Tu; Chunxia Zhang; Huiwen Yan; Yongting Luo; Ruirui Kong; Pushuai Wen; Zhongde Ye; Jianan Chen; Jing Feng; Feng Liu; Jane Y Wu; Xiyun Yan
Journal:  Cell Res       Date:  2015-02-06       Impact factor: 25.617

10.  Impaired tumor angiogenesis and VEGF-induced pathway in endothelial CD146 knockout mice.

Authors:  Qiqun Zeng; Zhenzhen Wu; Hongxia Duan; Xuan Jiang; Tao Tu; Di Lu; Yongting Luo; Ping Wang; Lina Song; Jing Feng; Dongling Yang; Xiyun Yan
Journal:  Protein Cell       Date:  2014-04-24       Impact factor: 14.870
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  6 in total

1.  CD146 as a promising therapeutic target for retinal and choroidal neovascularization diseases.

Authors:  Bai Xue; Ping Wang; Wenzhen Yu; Jing Feng; Jie Li; Rulian Zhao; Zhenglin Yang; Xiyun Yan; Hongxia Duan
Journal:  Sci China Life Sci       Date:  2021-10-29       Impact factor: 10.372

Review 2.  Role of Netrin-1 Signaling in Nerve Regeneration.

Authors:  Xin-Peng Dun; David B Parkinson
Journal:  Int J Mol Sci       Date:  2017-02-24       Impact factor: 5.923

3.  Pemetrexed-loaded nanoparticles targeted to malignant pleural mesothelioma cells: an in vitro study.

Authors:  Emanuela Cova; Laura Pandolfi; Miriam Colombo; Vanessa Frangipane; Simona Inghilleri; Monica Morosini; Simona Mrakic-Sposta; Sarah Moretti; Manuela Monti; Ymera Pignochino; Silvia Benvenuti; Davide Prosperi; Giulia Stella; Patrizia Morbini; Federica Meloni
Journal:  Int J Nanomedicine       Date:  2019-01-23

4.  Exposure to the natural alkaloid Berberine affects cardiovascular system morphogenesis and functionality during zebrafish development.

Authors:  Davide Martini; Cecilia Pucci; Chiara Gabellini; Mario Pellegrino; Massimiliano Andreazzoli
Journal:  Sci Rep       Date:  2020-10-15       Impact factor: 4.379

5.  CD146 mediates the anti-apoptotic role of Netrin-1 in endothelial progenitor cells under hypoxic conditions.

Authors:  Ru-Chao Jiang; Xue-Ying Zheng; Sheng-Lan Yang; Hai-Jie Shi; Jia-Hui Xi; Yong-Jian Zou; Hua-Qian Dou; Yun-Jing Wang; Yuan Qin; Xiao-Ling Zhang; Qing Xiao
Journal:  Mol Med Rep       Date:  2021-11-05       Impact factor: 2.952

6.  Exosomal lncRNA PCAT1 Promotes Tumor Circulating Cell-Mediated Colorectal Cancer Liver Metastasis by Regulating the Activity of the miR-329-3p/Netrin-1-CD146 Complex.

Authors:  Xingbao Fang; Yongping Xu; Kezhi Li; Peiwan Liu; Hong Zhang; Yang Jiang; Jianwei Tang; Yuehong Li
Journal:  J Immunol Res       Date:  2022-08-31       Impact factor: 4.493
  6 in total

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