Literature DB >> 25848487

Survival rates according to barcelona clinic liver cancer sub-staging system after transarterial embolization for intermediate hepatocellular carcinoma.

Leandro Armani Scaffaro1, Steffan Frosi Stella1, Mario Reis Alvares-Da-Silva1, Cleber Dario Pinto Kruel1.   

Abstract

AIM: To investigate the survival rates after transarterial embolization (TAE).
METHODS: One hundred third six hepatocellular carcinoma (HCC) patients [90 barcelona clinic liver cancer (BCLC) B] were submitted to TAE between August 2008 and December 2013 in a single center were retrospectively studied. TAE was performed via superselective catheterization followed by embolization with polyvinyl alcohol or microspheres. The date of the first embolization until death or the last follow-up date was used for the assessment of survival. The survival rates were calculated using the Kaplan-Meier method, and the groups were compared using the log-rank test.
RESULTS: The overall mean survival was 35.8 mo (95%CI: 25.1-52.0). The survival rates of the BCLC A patients (33.7%) were 98.9%, 79.0% and 58.0% at 12, 24 and 36 mo, respectively, and the mean survival was 38.1 mo (95%CI: 27.5-52.0). The survival rates of the BCLC B patients (66.2%) were 89.0%, 69.0% and 49.5% at 12, 24 and 36 mo, respectively, and the mean survival was 29.0 mo (95%CI: 17.2-34). The survival rates according to the BCLC B sub-staging showed significant differences between the groups, with mean survival rates in the B1, B2, B3 and B4 groups of 33.5 mo (95%CI: 32.8-34.3), 28.6 mo (95%CI: 27.5-29.8), 19.0 mo (95%CI: 17.2-20.9) and 13 mo, respectively (P = 0.013).
CONCLUSION: The BCLC sub-staging system could add additional prognosis information for post-embolization survival rates in HCC patients.

Entities:  

Keywords:  Barcelona clinic liver cancer; Hepatocellular carcinoma; Subclassification; Transarterial embolization

Year:  2015        PMID: 25848487      PMCID: PMC4381186          DOI: 10.4254/wjh.v7.i3.628

Source DB:  PubMed          Journal:  World J Hepatol


  13 in total

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Review 3.  Transarterial therapy for hepatocellular carcinoma: which technique is more effective? A systematic review of cohort and randomized studies.

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6.  Validation and modification of a proposed substaging system for patients with intermediate hepatocellular carcinoma.

Authors:  Jing-Houng Wang; Kwong-Ming Kee; Chih-Yun Lin; Chao-Hung Hung; Chien-Hung Chen; Chuan-Mo Lee; Sheng-Nan Lu
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7.  [Survival benefit with intraarterial techniques in hepatocellular carcinoma].

Authors:  Bruno Sangro
Journal:  Gastroenterol Hepatol       Date:  2014-07       Impact factor: 2.102

Review 8.  Heterogeneity of patients with intermediate (BCLC B) Hepatocellular Carcinoma: proposal for a subclassification to facilitate treatment decisions.

Authors:  Luigi Bolondi; Andrew Burroughs; Jean-François Dufour; Peter R Galle; Vincenzo Mazzaferro; Fabio Piscaglia; Jean Luc Raoul; Bruno Sangro
Journal:  Semin Liver Dis       Date:  2013-02-08       Impact factor: 6.115

9.  Management of hepatocellular carcinoma: an update.

Authors:  Jordi Bruix; Morris Sherman
Journal:  Hepatology       Date:  2011-03       Impact factor: 17.425

10.  Prospective randomized study of doxorubicin-eluting-bead embolization in the treatment of hepatocellular carcinoma: results of the PRECISION V study.

Authors:  Johannes Lammer; Katarina Malagari; Thomas Vogl; Frank Pilleul; Alban Denys; Anthony Watkinson; Michael Pitton; Geraldine Sergent; Thomas Pfammatter; Sylvain Terraz; Yves Benhamou; Yves Avajon; Thomas Gruenberger; Maria Pomoni; Herbert Langenberger; Marcus Schuchmann; Jerome Dumortier; Christian Mueller; Patrick Chevallier; Riccardo Lencioni
Journal:  Cardiovasc Intervent Radiol       Date:  2009-11-12       Impact factor: 2.740

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  7 in total

Review 1.  Hepatocellular carcinoma: Where are we?

Authors:  Roberto Mazzanti; Umberto Arena; Renato Tassi
Journal:  World J Exp Med       Date:  2016-02-20

2.  Transarterial radioembolization in patients with hepatocellular carcinoma of intermediate B2 substage.

Authors:  Alberta Cappelli; Paloma Sangro; Cristina Mosconi; Iris Deppe; Eleonora Terzi; Jose I Bilbao; Macarena Rodriguez-Fraile; Caterina De Benedittis; Jens Ricke; Rita Golfieri; Bruno Sangro
Journal:  Eur J Nucl Med Mol Imaging       Date:  2018-09-12       Impact factor: 9.236

Review 3.  Patients with Barcelona Clinic Liver Cancer Stages B and C Hepatocellular Carcinoma: Time for a Subclassification.

Authors:  Rita Golfieri; Irene Bargellini; Carlo Spreafico; Franco Trevisani
Journal:  Liver Cancer       Date:  2018-06-27       Impact factor: 11.740

4.  Proposal for subclassification to select patients for hepatectomy with intermediate hepatocellular carcinoma and Child-Pugh A liver function: A double-center study from China.

Authors:  Wei Xu; Quan Rao; Yongbo An; Mengyi Li; Gang Xu; Xinting Sang; Xin Lu; Zhongtao Zhang; Yilei Mao
Journal:  Medicine (Baltimore)       Date:  2018-08       Impact factor: 1.889

5.  Hepatocellular carcinoma staging systems: Hong Kong liver cancer vs Barcelona clinic liver cancer in a Western population.

Authors:  Laura Bainy Rodrigues de Freitas; Larisse Longo; Deivid Santos; Ivana Grivicich; Mário Reis Álvares-da-Silva
Journal:  World J Hepatol       Date:  2019-09-27

6.  Extending Surgical Resection for Hepatocellular Carcinoma Beyond Barcelona Clinic for Liver Cancer (BCLC) Stage A: A Novel Application of the Modified BCLC Staging System.

Authors:  Ian J Y Wee; Fiona N N Moe; Rehena Sultana; Reiko W T Ang; Pearly P S Quek; Brian Kim Poh Goh; Chung Yip Chan; Peng Chung Cheow; Alexander Y F Chung; Prema Raj Jeyaraj; Ye Xin Koh; Peter O P Mack; London Lucien P J Ooi; Ek Khoon Tan; Jin Yao Teo; Juinn Huar Kam; Jacelyn S S Chua; Ashley W Y Ng; Jade S Q Goh; Pierce K H Chow
Journal:  J Hepatocell Carcinoma       Date:  2022-08-17

7.  Transarterial Embolization for Hepatocellular Carcinoma: A Comparison between Nonspherical PVA and Microspheres.

Authors:  Leandro Armani Scaffaro; Cleber Dario Pinto Kruel; Steffan Frosi Stella; Gabriela Leal Gravina; Geraldo Machado Filho; Carlos Podalirio Borges de Almeida; Luiz Cezar Pontes Fonseca Pinto; Mario Reis Alvares-da-Silva; Cleber Rosito Pinto Kruel
Journal:  Biomed Res Int       Date:  2015-08-27       Impact factor: 3.411

  7 in total

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