Literature DB >> 25847956

Targeting Autophagy in BRAF-Mutant Tumors.

Andrew Thorburn1, Michael J Morgan2.   

Abstract

Recent studies have highlighted the opportunity to treat cancer by inhibiting autophagy, but have also raised important caveats with this idea. An article in this issue of Cancer Discovery adds to accumulating evidence suggesting that we should focus our efforts (at least initially) on specific tumors where we are most likely to see beneficial effects. ©2015 American Association for Cancer Research.

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Year:  2015        PMID： 25847956      PMCID： PMC4391230          DOI： 10.1158/2159-8290.CD-15-0222

Source DB:  PubMed          Journal:  Cancer Discov        ISSN： 2159-8274            Impact factor:   39.397


  10 in total

Review 1.  Deconvoluting the context-dependent role for autophagy in cancer.

Authors:  Eileen White
Journal:  Nat Rev Cancer       Date:  2012-04-26       Impact factor: 60.716

2.  Autophagy sustains mitochondrial glutamine metabolism and growth of BrafV600E-driven lung tumors.

Authors:  Anne M Strohecker; Jessie Yanxiang Guo; Gizem Karsli-Uzunbas; Sandy M Price; Guanghua Jim Chen; Robin Mathew; Martin McMahon; Eileen White
Journal:  Cancer Discov       Date:  2013-08-21       Impact factor: 39.397

3.  Targeting ER stress-induced autophagy overcomes BRAF inhibitor resistance in melanoma.

Authors:  Xiao-Hong Ma; Sheng-Fu Piao; Souvik Dey; Quentin McAfee; Giorgos Karakousis; Jessie Villanueva; Lori S Hart; Samuel Levi; Janice Hu; Gao Zhang; Rossitza Lazova; Vincent Klump; John M Pawelek; Xiaowei Xu; Wei Xu; Lynn M Schuchter; Michael A Davies; Meenhard Herlyn; Jeffrey Winkler; Constantinos Koumenis; Ravi K Amaravadi
Journal:  J Clin Invest       Date:  2014-02-24       Impact factor: 14.808

4.  Atg7 Overcomes Senescence and Promotes Growth of BrafV600E-Driven Melanoma.

Authors:  Xiaoqi Xie; Ju Yong Koh; Sandy Price; Eileen White; Janice M Mehnert
Journal:  Cancer Discov       Date:  2015-02-11       Impact factor: 39.397

5.  Autophagy is required for glucose homeostasis and lung tumor maintenance.

Authors:  Gizem Karsli-Uzunbas; Jessie Yanxiang Guo; Sandy Price; Xin Teng; Saurabh V Laddha; Sinan Khor; Nada Y Kalaany; Tyler Jacks; Chang S Chan; Joshua D Rabinowitz; Eileen White
Journal:  Cancer Discov       Date:  2014-05-29       Impact factor: 39.397

6.  Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterations.

Authors:  Annan Yang; N V Rajeshkumar; Xiaoxu Wang; Shinichi Yabuuchi; Brian M Alexander; Gerald C Chu; Daniel D Von Hoff; Anirban Maitra; Alec C Kimmelman
Journal:  Cancer Discov       Date:  2014-05-29       Impact factor: 39.397

7.  Autophagy inhibition improves chemosensitivity in BRAF(V600E) brain tumors.

Authors:  Jean M Mulcahy Levy; Joshua C Thompson; Andrea M Griesinger; Vladimir Amani; Andrew M Donson; Diane K Birks; Michael J Morgan; David M Mirsky; Michael H Handler; Nicholas K Foreman; Andrew Thorburn
Journal:  Cancer Discov       Date:  2014-05-13       Impact factor: 39.397

8.  Autophagy and its effects: making sense of double-edged swords.

Authors:  Andrew Thorburn
Journal:  PLoS Biol       Date:  2014-10-14       Impact factor: 8.029

9.  Regulation of autophagy and chloroquine sensitivity by oncogenic RAS in vitro is context-dependent.

Authors:  Michael J Morgan; Graciela Gamez; Christina Menke; Ariel Hernandez; Jacqueline Thorburn; Freddi Gidan; Leah Staskiewicz; Shellie Morgan; Christopher Cummings; Paola Maycotte; Andrew Thorburn
Journal:  Autophagy       Date:  2014-08-13       Impact factor: 16.016

10.  p53 status determines the role of autophagy in pancreatic tumour development.

Authors:  Mathias T Rosenfeldt; Jim O'Prey; Jennifer P Morton; Colin Nixon; Gillian MacKay; Agata Mrowinska; Amy Au; Taranjit Singh Rai; Liang Zheng; Rachel Ridgway; Peter D Adams; Kurt I Anderson; Eyal Gottlieb; Owen J Sansom; Kevin M Ryan
Journal:  Nature       Date:  2013-12-04       Impact factor: 49.962
  10 in total
  6 in total

Review 1.  Targeting autophagy in cancer.

Authors:  Jean M Mulcahy Levy; Christina G Towers; Andrew Thorburn
Journal:  Nat Rev Cancer       Date:  2017-07-28       Impact factor: 60.716

2.  S5, a Withanolide Isolated from Physalis Pubescens L., Induces G2/M Cell Cycle Arrest via the EGFR/P38 Pathway in Human Melanoma A375 Cells.

Authors:  Yuqi Fan; Yiwei Mao; Shijie Cao; Guiyang Xia; Qiang Zhang; Hongyang Zhang; Feng Qiu; Ning Kang
Journal:  Molecules       Date:  2018-12-01       Impact factor: 4.411

3.  Proteomic Changes in the Monolayer and Spheroid Melanoma Cell Models of Acquired Resistance to BRAF and MEK1/2 Inhibitors.

Authors:  Ramon Martinez; Weiliang Huang; Heather Buck; Samantha Rea; Amy E Defnet; Maureen A Kane; Paul Shapiro
Journal:  ACS Omega       Date:  2022-01-18

4.  The Histone Deacetylase Inhibitor ITF2357 (Givinostat) Targets Oncogenic BRAF in Melanoma Cells and Promotes a Switch from Pro-Survival Autophagy to Apoptosis.

Authors:  Adriana Celesia; Antonietta Notaro; Marzia Franzò; Marianna Lauricella; Antonella D'Anneo; Daniela Carlisi; Michela Giuliano; Sonia Emanuele
Journal:  Biomedicines       Date:  2022-08-17

5.  Metastatic risk and resistance to BRAF inhibitors in melanoma defined by selective allelic loss of ATG5.

Authors:  María García-Fernández; Panagiotis Karras; Agnieszka Checinska; Estela Cañón; Guadalupe T Calvo; Gonzalo Gómez-López; Metehan Cifdaloz; Angel Colmenar; Luis Espinosa-Hevia; David Olmeda; María S Soengas
Journal:  Autophagy       Date:  2016-07-27       Impact factor: 16.016

Review 6.  Autophagy as a therapeutic target in pancreatic cancer.

Authors:  Max Piffoux; Erwan Eriau; Philippe A Cassier
Journal:  Br J Cancer       Date:  2020-09-15       Impact factor: 7.640
  6 in total

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