Xiu-juan Wang1, Xiang-rong Rao2, Shen Li1, Li Wang1, Chang Liu1, Gai-hua Zhang1, Dong-yan Han1, Yu Zhao1, Nan-nan Zhang3, Xue-xia Li4, Shuai Chen5. 1. Department of Nephropathy, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China. 2. Department of Nephropathy, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China. raoyisheng@163.com. 3. Department of Nephropathy, Beijing Fangshan Hospital of Traditional Chinese Medicine, Beijing, 102400, China. 4. Department of Nephropathy, The Second People's Hospital of Zhuhai, Zhuhai, Guangdong Province, 519000, China. 5. Department of Nephropathy, Beijing Miyun Hospital of Traditional Chinese Medicine, Beijing, 101500, China.
Abstract
OBJECTIVE: To investigate the effect of Huanshuai Recipe Oral Liquid ([characters: see text], HSR) on retarding the progression of renal dysfunction in patients with atherosclerotic renal artery stenosis (ARAS). METHODS: A total of 52 ARAS patients with the Chinese medicine (CM) syndrome of qi deficiency and blood stasis, phlegm and dampness retention were recruited and randomly assigned into the treatment group (36 cases) and the control group (16 cases). Both groups received a basic treatment (high-quality low-protein diet, blood pressure control, lipid-lowering, correcting the acidosis, etc.). In addition, the treatment group received 20 mL HSR and the control group received placebo, 3 times a day for 6 months. Renal function (serum creatinine, blood urea nitrogen and uric acid) and blood lipids (cholesterol, triglycerides and low density lipoprotein) were examined monthly. The estimated glomerular filtration rate (eGFR) and CM syndrome score were compared between groups. RESULTS: After treatment, compared with the control group, the serum creatinine level, uric acid level and CM syndrome score of the treatment group were significantly decreased (P<0.05 or P<0.01), and the eGFR in the treatment group were significantly increased (P<0.05). CONCLUSION:HSR can effectively improve the renal function and clinical symptoms of ARAS patients.
RCT Entities:
OBJECTIVE: To investigate the effect of Huanshuai Recipe Oral Liquid ([characters: see text], HSR) on retarding the progression of renal dysfunction in patients with atherosclerotic renal artery stenosis (ARAS). METHODS: A total of 52 ARAS patients with the Chinese medicine (CM) syndrome of qi deficiency and blood stasis, phlegm and dampness retention were recruited and randomly assigned into the treatment group (36 cases) and the control group (16 cases). Both groups received a basic treatment (high-quality low-protein diet, blood pressure control, lipid-lowering, correcting the acidosis, etc.). In addition, the treatment group received 20 mL HSR and the control group received placebo, 3 times a day for 6 months. Renal function (serum creatinine, blood ureanitrogen and uric acid) and blood lipids (cholesterol, triglycerides and low density lipoprotein) were examined monthly. The estimated glomerular filtration rate (eGFR) and CM syndrome score were compared between groups. RESULTS: After treatment, compared with the control group, the serum creatinine level, uric acid level and CM syndrome score of the treatment group were significantly decreased (P<0.05 or P<0.01), and the eGFR in the treatment group were significantly increased (P<0.05). CONCLUSION:HSR can effectively improve the renal function and clinical symptoms of ARAS patients.
Authors: John H Rundback; David Sacks; K Craig Kent; Christopher Cooper; Daniel Jones; Timothy Murphy; Kenneth Rosenfield; Christopher White; Michael Bettmann; Stanley Cortell; Jules Puschett; Dan Clair; Patricia Cole Journal: Circulation Date: 2002-09-17 Impact factor: 29.690
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