Silvia Rios Romenets1, Julius Anang1, Seyed-Mohammad Fereshtehnejad2, Amelie Pelletier1, Ronald Postuma3. 1. Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada. 2. Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden. 3. Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada. Electronic address: ron.postuma@mcgill.ca.
Abstract
OBJECTIVE: To determine effects of Argentine tango on motor and non-motor manifestations of Parkinson's disease. DESIGN: Randomized control trial. PARTICIPANTS: Forty patients with idiopathic Parkinson's disease. SETTING: Movement disorder clinic and dance studio. INTERVENTION: Two randomized groups: group (N=18) with 24 partnered tango classes, and control self-directed exercise group (N=15). MAIN OUTCOMES MEASURES: The primary outcome was overall motor severity. Secondary outcomes included other motor measures, balance, cognition, fatigue, apathy, depression and quality of life. RESULTS: On the primary intention-to-treat analysis there was no difference in motor severity between groups MDS-UPDRS-3 (1.6 vs.1.2-point reduction, p=0.85). Patient-rated clinical global impression of change did not differ (p=0.33), however examiner rating improved in favor of tango (p=0.02). Mini-BESTest improved in the tango group compared to controls (0.7±2.2 vs. -2.7±5.9, p=0.032). Among individual items, tango improved in both simple TUG time (-1.3±1.6s vs. 0.1±2.3, p=0.042) and TUG Dual Task score (0.4±0.9 vs. -0.2±0.4, p=0.012), with borderline improvement in walk with pivot turns (0.2±0.5 vs. -0.1±0.5, p=0.066). MoCa (0.4±1.6 vs. -0.6±1.5, p=0.080) and FSS (-3.6±10.5 vs. 2.5±6.2, p=0.057) showed a non-significant trend toward improvement in the tango group. Tango participants found the activity more enjoyable (p<0.001) and felt more "overall" treatment satisfaction (p<0.001). We found no significant differences in other outcomes or adverse events. CONCLUSION:Argentine tango can improve balance, and functional mobility, and may have modest benefits upon cognition and fatigue in Parkinson's disease. These findings must be confirmed in longer-term trials explicitly powered for cognition and fatigue.
RCT Entities:
OBJECTIVE: To determine effects of Argentinetango on motor and non-motor manifestations of Parkinson's disease. DESIGN: Randomized control trial. PARTICIPANTS: Forty patients with idiopathic Parkinson's disease. SETTING:Movement disorder clinic and dance studio. INTERVENTION: Two randomized groups: group (N=18) with 24 partnered tango classes, and control self-directed exercise group (N=15). MAIN OUTCOMES MEASURES: The primary outcome was overall motor severity. Secondary outcomes included other motor measures, balance, cognition, fatigue, apathy, depression and quality of life. RESULTS: On the primary intention-to-treat analysis there was no difference in motor severity between groups MDS-UPDRS-3 (1.6 vs.1.2-point reduction, p=0.85). Patient-rated clinical global impression of change did not differ (p=0.33), however examiner rating improved in favor of tango (p=0.02). Mini-BESTest improved in the tango group compared to controls (0.7±2.2 vs. -2.7±5.9, p=0.032). Among individual items, tango improved in both simple TUG time (-1.3±1.6s vs. 0.1±2.3, p=0.042) and TUG Dual Task score (0.4±0.9 vs. -0.2±0.4, p=0.012), with borderline improvement in walk with pivot turns (0.2±0.5 vs. -0.1±0.5, p=0.066). MoCa (0.4±1.6 vs. -0.6±1.5, p=0.080) and FSS (-3.6±10.5 vs. 2.5±6.2, p=0.057) showed a non-significant trend toward improvement in the tango group. Tangoparticipants found the activity more enjoyable (p<0.001) and felt more "overall" treatment satisfaction (p<0.001). We found no significant differences in other outcomes or adverse events. CONCLUSION:Argentinetango can improve balance, and functional mobility, and may have modest benefits upon cognition and fatigue in Parkinson's disease. These findings must be confirmed in longer-term trials explicitly powered for cognition and fatigue.
Authors: Achinoam Faust-Socher; Sarah Duff-Canning; Arthur Grabovsky; Melissa J Armstrong; Brandon Rothberg; Paul J Eslinger; Christopher A Meaney; Ruth B Schneider; David F Tang-Wai; Susan H Fox; Cindy Zadikoff; Nancy Kennedy; Kelvin L Chou; Carol Persad; Irene Litvan; Benjamin T Mast; Adam T Gerstenecker; Sandra Weintraub; William Reginold; Connie Marras Journal: Dement Geriatr Cogn Disord Date: 2019-07-17 Impact factor: 2.959