Wei-Te Wu1, Su-Shan Tsai2, Tung-Sheng Shih3,4, Ming-Hsiu Lin3, Tzu-Chieh Chou4, Hua Ting5,6, Trong-Neng Wu1,7, Saou-Hsing Liou8,9,10. 1. Division of Environmental Health and Occupational Medicine, National Health Research Institutes, 35 Keyan Road, Zhunan Town, Miaoli County, 35053, Taiwan, Republic of China. 2. Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan. 3. Institute of Labor, Occupational Safety and Health, Ministry of Labor, Taipei, Taiwan. 4. Department of Public Health, China Medical University, Taichung, Taiwan. 5. Department of Physical Medicine and Rehabilitation, Chung Shan Medical University, Taichung, Taiwan. 6. Center of Sleep Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan. 7. Department of Nursing, Hungkuang University, Taichung, Taiwan. 8. Division of Environmental Health and Occupational Medicine, National Health Research Institutes, 35 Keyan Road, Zhunan Town, Miaoli County, 35053, Taiwan, Republic of China. shliou@nhri.org.tw. 9. Department of Public Health, China Medical University, Taichung, Taiwan. shliou@nhri.org.tw. 10. Department of Public Health, National Defense Medical Center, Taipei, Taiwan. shliou@nhri.org.tw.
Abstract
BACKGROUND: It is unclear whether obstructive sleep apnea (OSA) is independently associated with increased levels of the acute-phase reactant C-reactive protein (CRP). The purpose of this study was to evaluate the relationship between OSA and high-sensitivity CRP (hs-CRP) levels according to the presence or absence of metabolic syndrome (MetS). METHODS: This study recruited 245 male bus drivers from one transportation company in Taiwan. Each participant was evaluated by a polysomnography (PSG) test, blood lipids examination, and hs-CRP. Severity of OSA was categorized according to the apnea-hypopnea index (AHI). RESULTS: Subjects were categorized into severe OSA group (n = 44; 17.9 %), moderate and mild OSA group (n = 117; 47.8 %), and non-OSA group (n = 84; 34.3 %). AHI had a significant association with hs-CRP (β = 0.125, p = 0.009) adjusting for age, smoking, drinking, and MetS status. Hs-CRP was elevated with severe OSA (β = 0.533, p = 0.005) even adjusting for BMI and MetS. Moreover, there was an independent effect for adjusted odds ratios (AORs) between the stratification of the severity for OSA and MetS. CONCLUSION: Elevated hs-CRP level is associated with severe OSA, independent of known confounders. The effect of OSA in CRP is independent of MetS was identified.
BACKGROUND: It is unclear whether obstructive sleep apnea (OSA) is independently associated with increased levels of the acute-phase reactant C-reactive protein (CRP). The purpose of this study was to evaluate the relationship between OSA and high-sensitivity CRP (hs-CRP) levels according to the presence or absence of metabolic syndrome (MetS). METHODS: This study recruited 245 male bus drivers from one transportation company in Taiwan. Each participant was evaluated by a polysomnography (PSG) test, blood lipids examination, and hs-CRP. Severity of OSA was categorized according to the apnea-hypopnea index (AHI). RESULTS: Subjects were categorized into severe OSA group (n = 44; 17.9 %), moderate and mild OSA group (n = 117; 47.8 %), and non-OSA group (n = 84; 34.3 %). AHI had a significant association with hs-CRP (β = 0.125, p = 0.009) adjusting for age, smoking, drinking, and MetS status. Hs-CRP was elevated with severe OSA (β = 0.533, p = 0.005) even adjusting for BMI and MetS. Moreover, there was an independent effect for adjusted odds ratios (AORs) between the stratification of the severity for OSA and MetS. CONCLUSION: Elevated hs-CRP level is associated with severe OSA, independent of known confounders. The effect of OSA in CRP is independent of MetS was identified.
Authors: Mary S M Ip; Bing Lam; Matthew M T Ng; Wah Kit Lam; Kenneth W T Tsang; Karen S L Lam Journal: Am J Respir Crit Care Med Date: 2002-03-01 Impact factor: 21.405
Authors: M Kohler; L Ayers; J C T Pepperell; K L Packwood; B Ferry; N Crosthwaite; S Craig; M M Siccoli; R J O Davies; J R Stradling Journal: Thorax Date: 2008-09-11 Impact factor: 9.139