Esther P Verduin1,2, Anneke Brand2, Rutger A Middelburg1,3, Henk Schonewille4. 1. Center for Clinical Transfusion Research, Sanquin Research. 2. Department of Immunohematology and Blood Transfusion. 3. Department of Clinical Epidemiology, Leiden University Medical Center. 4. Sanquin-LUMC Jon J. Van Rood Center for Clinical Transfusion Research, Leiden, The Netherlands.
Abstract
BACKGROUND: More women than men are encountered with red blood cell (RBC) antibodies. It is not clear whether this difference is explained by more immunizing events in women or by a different acting immune system. To assess whether there is a difference in the posttransfusion RBC alloimmunization rate between women and men, a study on RBC alloimmunization during a 5-year period was conducted in patients with at least one antibody follow-up more than 14 days after transfusion. STUDY DESIGN AND METHODS: Data on transfusion and antibody follow-up characteristics in female and male transfusion recipients from the Leiden University Medical Center laboratory database were collected. Hazard ratios of alloimmunization, according to sex of the transfusion recipient, were estimated using Cox proportional hazards regression models taking possible confounders into account. RESULTS: From a total of 1699 women and 1969 men who were eligible, 4.2% of women and 3.4% of men (relative risk, 1.3; 95% confidence interval [CI], 0.9-1.8) developed posttransfusion antibodies. Adjustment for confounders resulted in a relative 80% higher risk in women older than 45 years of age. CONCLUSION: Elder women beyond childbearing age have a higher risk of posttransfusion antibody formation compared to men.
BACKGROUND: More women than men are encountered with red blood cell (RBC) antibodies. It is not clear whether this difference is explained by more immunizing events in women or by a different acting immune system. To assess whether there is a difference in the posttransfusion RBC alloimmunization rate between women and men, a study on RBC alloimmunization during a 5-year period was conducted in patients with at least one antibody follow-up more than 14 days after transfusion. STUDY DESIGN AND METHODS: Data on transfusion and antibody follow-up characteristics in female and male transfusion recipients from the Leiden University Medical Center laboratory database were collected. Hazard ratios of alloimmunization, according to sex of the transfusion recipient, were estimated using Cox proportional hazards regression models taking possible confounders into account. RESULTS: From a total of 1699 women and 1969 men who were eligible, 4.2% of women and 3.4% of men (relative risk, 1.3; 95% confidence interval [CI], 0.9-1.8) developed posttransfusion antibodies. Adjustment for confounders resulted in a relative 80% higher risk in women older than 45 years of age. CONCLUSION: Elder women beyond childbearing age have a higher risk of posttransfusion antibody formation compared to men.
Authors: Matthew S Karafin; Matt Westlake; Ronald G Hauser; Christopher A Tormey; Philip J Norris; Nareg H Roubinian; Yanyun Wu; Darrell J Triulzi; Steve Kleinman; Jeanne E Hendrickson Journal: Br J Haematol Date: 2018-04-19 Impact factor: 6.998
Authors: Johanne Rozema; Christiaan L Slim; Nic J G M Veeger; Robby E Kibbelaar; Harry de Wit; Eric N van Roon; Mels Hoogendoorn Journal: Blood Transfus Date: 2020-12-16 Impact factor: 3.443
Authors: Josine A Oud; Dorothea Evers; Masja de Haas; Karen M K de Vooght; Daan van de Kerkhof; Nel Som; Nathalie C V Péquériaux; Francisca Hudig; Arjan Albersen; Johanna G van der Bom; Jaap Jan Zwaginga Journal: Br J Haematol Date: 2021-08-03 Impact factor: 8.615
Authors: Joost H J van Sambeeck; Puck D de Wit; Jessie Luken; Barbera Veldhuisen; Katja van den Hurk; Anne van Dongen; Maria M W Koopman; Marian G J van Kraaij; C Ellen van der Schoot; Henk Schonewille; Wim L A M de Kort; Mart P Janssen Journal: Front Med (Lausanne) Date: 2018-07-25