| Literature DB >> 25846863 |
Valerie Vanhooren1, Alexander Navarrete Santos2, Konstantinos Voutetakis3, Isabelle Petropoulos4, Claude Libert1, Andreas Simm2, Efstathios S Gonos3, Bertrand Friguet5.
Abstract
Changes in the abundance and post-translational modification of proteins and accumulation of some covalently modified proteins have been proposed to represent hallmarks of biological ageing. Within the frame of the Mark-Age project, the workpackage dedicated to "markers based on proteins and their modifications" has been firstly focused on enzymatic and non-enzymatic post-translational modifications of serum proteins by carbohydrates. The second focus of the workpackage has been directed towards protein maintenance systems that are involved either in protein quality control (ApoJ/Clusterin) or in the removal of oxidatively damaged proteins through degradation and repair (proteasome and methionine sulfoxide reductase systems). This review describes the most relevant features of these protein modifications and maintenance systems, their fate during ageing and/or their implication in ageing and longevity.Entities:
Keywords: Ageing; Biomarkers; Protein maintenance; Protein modification
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Year: 2015 PMID： 25846863 DOI： 10.1016/j.mad.2015.03.009
Source DB: PubMed Journal: Mech Ageing Dev ISSN： 0047-6374 Impact factor: 5.432