Literature DB >> 25846235

A bioelectronic system for insulin release triggered by ketone body mimicking diabetic ketoacidosis in vitro.

Maria Gamella1, Nataliia Guz, José M Pingarrón, Roshanak Aslebagh, Costel C Darie, Evgeny Katz.   

Abstract

A bioelectronic system composed of two modified electrodes, one activated in the presence of ketone bodies, a biomarker of diabetic ketoacidosis, and another releasing insulin upon receiving a signal, was designed and tested in vitro to operate as a Sense-and-Act device. The functional integration of biomarker-sensing and insulin-releasing electrodes represents a step to a theranostic system with autonomous operation.

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Year:  2015        PMID： 25846235     DOI： 10.1039/c5cc01498k

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  3 in total

1.  Mass spectrometry-based proteomics of oxidative stress: Identification of 4-hydroxy-2-nonenal (HNE) adducts of amino acids using lysozyme and bovine serum albumin as model proteins.

Authors:  Roshanak Aslebagh; Bruce A Pfeffer; Steven J Fliesler; Costel C Darie
Journal:  Electrophoresis       Date:  2016-06-07       Impact factor: 3.535

2.  Fusing Sensor Paradigms to Acquire Chemical Information: An Integrative Role for Smart Biopolymeric Hydrogels.

Authors:  Eunkyoung Kim; Yi Liu; Hadar Ben-Yoav; Thomas E Winkler; Kun Yan; Xiaowen Shi; Jana Shen; Deanna L Kelly; Reza Ghodssi; William E Bentley; Gregory F Payne
Journal:  Adv Healthc Mater       Date:  2016-09-12       Impact factor: 9.933

3.  Atrial electrophysiological and molecular remodelling induced by obstructive sleep apnoea.

Authors:  Devika Channaveerappa; Jacob C Lux; Kelly L Wormwood; Timothy A Heintz; Meredith McLerie; Jacqueline A Treat; Hannah King; Donia Alnasser; Robert J Goodrow; Glenn Ballard; Robert Decker; Costel C Darie; Brian K Panama
Journal:  J Cell Mol Med       Date:  2017-04-12       Impact factor: 5.310
  3 in total

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