Ecmel Isik Kaygusuz1, Meryem Kurek Eken2, Oya Nermin Sivrikoz3, Handan Cetiner1. 1. a Department of Pathology and. 2. b Department of Gynecology , Zeynep Kamil Maternity and Children's Training and Research Hospital , Istanbul , Turkey , and. 3. c Department of Pathology , Sifa University , Izmir , Turkey.
Abstract
OBJECTIVE: To discuss the pathological features of sirenomelia in the light of our 10 cases and review the current theories. METHODS: We identified 10 patients with sirenomelia from our hospital database. All clinical details and the autopsy features of 10 cases were noted. RESULTS: Of the 10 children with sirenomelia seven had bilateral renal agenesis, three had bladder agenesis and one had a renal hypoplasia. Single umbilical artery was found in 60% of children with sirenomelia. External genitalia was ambiguous in seven of 10 patients. CONCLUSIONS: Even though the etiology of caudal regression syndrome (CRS) and sirenomelia remains unknown we tend to believe that sirenomelia and CRS might be different entities.
OBJECTIVE: To discuss the pathological features of sirenomelia in the light of our 10 cases and review the current theories. METHODS: We identified 10 patients with sirenomelia from our hospital database. All clinical details and the autopsy features of 10 cases were noted. RESULTS: Of the 10 children with sirenomelia seven had bilateral renal agenesis, three had bladder agenesis and one had a renal hypoplasia. Single umbilical artery was found in 60% of children with sirenomelia. External genitalia was ambiguous in seven of 10 patients. CONCLUSIONS: Even though the etiology of caudal regression syndrome (CRS) and sirenomelia remains unknown we tend to believe that sirenomelia and CRS might be different entities.
Entities:
Keywords:
Caudal regression syndrome; single umbilical artery; sirenomelia
Authors: Mohammad A Alomar; Mohammad A Alghafees; Abdulaziz Aljurayyad; Hamad S Alsuhaibani; Sultan S Almaiman; Tariq S Alotaibi Journal: Cureus Date: 2022-05-30