| Literature DB >> 25843596 |
K M Kortüm1, Y X Zhu1, C X Shi1, P Jedlowski1, A K Stewart2.
Abstract
Immunomodulation is an established treatment strategy in multiple myeloma with thalidomide and its derivatives lenalidomide and pomalidomide as its FDA approved representatives. Just recently the method of action of these cereblon binding molecules was deciphered and results from large phase 3 trials confirmed the backbone function of this drug family in various combination therapies. This review details the to-date knowledge concerning mechanism of IMiD action, clinical applications and plausible escape mechanisms in which cells may become resistant/refractory to cereblon binding molecule based treatment. Published by Elsevier Ltd.Entities:
Keywords: Aiolos; Cereblon; Cereblon binding molecules; IMiDs; Ikaros; Lenalidomide; Multiple myeloma; Pomalidomide; Thalidomide
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Year: 2015 PMID： 25843596 DOI： 10.1016/j.blre.2015.03.003
Source DB: PubMed Journal: Blood Rev ISSN： 0268-960X Impact factor: 8.250