Literature DB >> 2584136

AT2433-A1, AT2433-A2, AT2433-B1, and AT2433-B2 novel antitumor antibiotic compounds produced by Actinomadura melliaura. Taxonomy, fermentation, isolation and biological properties.

J A Matson1, C Claridge, J A Bush, J Titus, W T Bradner, T W Doyle, A C Horan, M Patel.   

Abstract

Compounds AT2433-A1 (A1), AT2433-A2 (A2), AT2433-B1 (B1), and AT2433-B2 (B2) were isolated from the cultured broth of Actinomadura melliaura sp. nov. (SCC 1655). Structurally these materials are closely related to rebeccamycin (1), an indolocarbazole antitumor antibiotic. A1, A2, B1, and B2 were active against Staphylococcus aureus A9537, Streptococcus faecalis A20688, Streptococcus faecium (ATCC 9790), Micrococcus lutea (ATCC 9341), Bacillus subtilis (ATCC 6633). A1 and B1 were active against P388 leukemia in mice.

Entities:  

Mesh：

Substances：

Year:  1989        PMID： 2584136     DOI： 10.7164/antibiotics.42.1547

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  7 in total

1.  Structural characterization of AtmS13, a putative sugar aminotransferase involved in indolocarbazole AT2433 aminopentose biosynthesis.

Authors:  Shanteri Singh; Youngchang Kim; Fengbin Wang; Lance Bigelow; Michael Endres; Madan K Kharel; Gyorgy Babnigg; Craig A Bingman; Andrzej Joachimiak; Jon S Thorson; George N Phillips
Journal:  Proteins       Date:  2015-07-01

2.  Cytotoxic Indolocarbazoles from Actinomadura melliaura ATCC 39691.

Authors:  Khaled A Shaaban; Sherif I Elshahawi; Xiachang Wang; Jamie Horn; Madan K Kharel; Markos Leggas; Jon S Thorson
Journal:  J Nat Prod       Date:  2015-06-19       Impact factor: 4.050

3.  DNA sequence recognition by the indolocarbazole antitumor antibiotic AT2433-B1 and its diastereoisomer.

Authors:  Carolina Carrasco; Michaël Facompré; John D Chisholm; David L Van Vranken; W David Wilson; Christian Bailly
Journal:  Nucleic Acids Res       Date:  2002-04-15       Impact factor: 16.971

4.  Characterization of Early Enzymes Involved in TDP-Aminodideoxypentose Biosynthesis en Route to Indolocarbazole AT2433.

Authors:  Pauline Peltier-Pain; Shanteri Singh; Jon S Thorson
Journal:  Chembiochem       Date:  2015-09-18       Impact factor: 3.164

5.  Divergent pathways in the biosynthesis of bisindole natural products.

Authors:  Katherine S Ryan; Catherine L Drennan
Journal:  Chem Biol       Date:  2009-04-24

6.  Antitumor effect of KT6124, a novel derivative of protein kinase inhibitor K-252a, and its mechanism of action.

Authors:  S Akinaga; T Ashizawa; K Gomi; H Ohno; M Morimoto; C Murakata; M Okabe
Journal:  Cancer Chemother Pharmacol       Date:  1992       Impact factor: 3.333

7.  A Rebeccamycin Analog Provides Plasmid-Encoded Niche Defense.

Authors:  Ethan B Van Arnam; Antonio C Ruzzini; Clarissa S Sit; Cameron R Currie; Jon Clardy
Journal:  J Am Chem Soc       Date:  2015-11-10       Impact factor: 15.419
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.