Ahmet Çağrı Aykan1, Tayyar Gökdeniz2, Ilker Gül2, Ezgi Kalaycıoğlu2, Mustafa Çetin2, Engin Hatem2, Ismail Gökhan Çavuşoğlu3, Can Yücel Karabay4, Ahmet Güler4, Duygun Altıntaş Aykan5, Mustafa Yıldız4. 1. Department of Cardiology, Ahi Evren Chest Cardiovascular Surgery Education and Research Hospital, Trabzon, Turkey. Electronic address: ahmetaykan@yahoo.com. 2. Department of Cardiology, Ahi Evren Chest Cardiovascular Surgery Education and Research Hospital, Trabzon, Turkey. 3. Department of Radiology, Ahi Evren Chest Cardiovascular Surgery Education and Research Hospital, Trabzon, Turkey. 4. Department of Cardiology, Koşuyolu Kartal Heart Training and Research Hospital, Istanbul, Turkey. 5. Department of Pharmacology, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey.
Abstract
OBJECTIVE: The aim of this study is to evaluate the efficacy and safety of two doses of heparin, a low dose (2500 IU) and a standard dose (5000 IU) in patients who underwenttransradial coronary angiography (TRCAG). METHODS: A total of 459 consecutive patients were included in the present study, 217 in the 2500-IU heparin group and 242 in the 5000-IU heparin group. Radial artery patency was evaluated one month after the TRCAG with Doppler ultrasonography. RESULTS: The RAO was observed in 15 (3.3%) patients. The RAO was significantly higher in 2500 IU heparin group than 5000 IU heparin group (5.5% vs 1.2% p=0.010, respectively). Female gender (Odds ratio (OR)=66.135, p=0.002, 95% confidence interval (CI)=4.584-954.131), sheath removal time (OR=1.496, p<0.001, 95% CI=1.254-1.784) and administration of 2500 IU heparin (OR=9.758, p=0.034, 95% CI=1.195-79.695) were the independent predictors of RAO in multivariate regression analysis. While the presence of hypertension was independently associated with radial artery patency in multivariate regression analysis (OR=0.022, p=0.005, 95% CI=0.002-0.307). CONCLUSION: The patients in the standard dose heparin group had lower RAO rates compared to low dose group in this study. This suggests that using the current technique, standard dose of heparin is still required for transradial diagnostic angiography.
RCT Entities:
OBJECTIVE: The aim of this study is to evaluate the efficacy and safety of two doses of heparin, a low dose (2500 IU) and a standard dose (5000 IU) in patients who underwent transradial coronary angiography (TRCAG). METHODS: A total of 459 consecutive patients were included in the present study, 217 in the 2500-IU heparin group and 242 in the 5000-IU heparin group. Radial artery patency was evaluated one month after the TRCAG with Doppler ultrasonography. RESULTS: The RAO was observed in 15 (3.3%) patients. The RAO was significantly higher in 2500 IU heparin group than 5000 IU heparin group (5.5% vs 1.2% p=0.010, respectively). Female gender (Odds ratio (OR)=66.135, p=0.002, 95% confidence interval (CI)=4.584-954.131), sheath removal time (OR=1.496, p<0.001, 95% CI=1.254-1.784) and administration of 2500 IU heparin (OR=9.758, p=0.034, 95% CI=1.195-79.695) were the independent predictors of RAO in multivariate regression analysis. While the presence of hypertension was independently associated with radial artery patency in multivariate regression analysis (OR=0.022, p=0.005, 95% CI=0.002-0.307). CONCLUSION: The patients in the standard dose heparin group had lower RAO rates compared to low dose group in this study. This suggests that using the current technique, standard dose of heparin is still required for transradial diagnostic angiography.
Authors: Muhammad Rashid; Chun Shing Kwok; Samir Pancholy; Sanjay Chugh; Sasko A Kedev; Ivo Bernat; Karim Ratib; Adrian Large; Doug Fraser; James Nolan; Mamas A Mamas Journal: J Am Heart Assoc Date: 2016-01-25 Impact factor: 5.501
Authors: Dmitrii V Ognerubov; Alexander Sedaghat; Sergey I Provatorov; Andrey S Tereshchenko; Olivier F Bertrand; Ivo Bernat; Goar K Arutyunyan; Olga A Pogorelova; Maria I Tripoten; Tatyana V Balakhonova; Anatoliy N Samko; Evgeny V Merkulov Journal: J Interv Cardiol Date: 2020-10-23 Impact factor: 2.279