Pier Luigi Zinzani1, Umberto Vitolo2, Simonetta Viviani3, Paolo Corradini4, Giovanna Motta5, Monica Tani6, Nicola Cascavilla7, Stefan Hohaus8, Francesco Merli9, Lisa Argnani10, Alessandro Broccoli10. 1. Institute of Hematology "L. e A. Seràgnoli," "Sant'Orsola-Malpighi" University Hospital, Bologna, Italy. Electronic address: pierluigi.zinzani@unibo.it. 2. Azienda Ospedaliero-Universitaria "Città della Salute e della Scienza di Torino," Turin, Italy. 3. Medical Oncology Unit 2, Department of Medical Oncology, Fondazione IRCCS "Istituto Nazionale Tumori," Milan, Italy. 4. Division of Hematology, Fondazione IRCCS "Istituto Nazionale Tumori," Milan, Italy. 5. Division of Hematology and Bone Marrow Transplant, "Vittorio Emanuele" University Hospital, Catania, Italy. 6. Hematology Unit, Department of Oncology and Hematology, "Santa Maria delle Croci" Hospital, Ravenna, Italy. 7. Division of Hematology, IRCCS "Casa Sollievo della Sofferenza," San Giovanni Rotondo, Italy. 8. Institute of Hematology, "Università Cattolica del Sacro Cuore," Rome, Italy. 9. Department of Oncology and Advanced Technologies, IRCCS "Arcispedale Santa Maria Nuova," Reggio Emilia, Italy. 10. Institute of Hematology "L. e A. Seràgnoli," "Sant'Orsola-Malpighi" University Hospital, Bologna, Italy.
Abstract
BACKGROUND: The optimal treatment of patients with heavily pretreated Hodgkin's lymphoma is controversial. Brentuximab vedotin is an active single agent in this context. Also, bendamustine can be regarded as a safe and effective alternative for patients with relapse after autologous transplantation and as an interesting cytoreductive strategy before allogeneic transplantation. PATIENTS AND METHODS: An observational, multicenter, retrospective study is reported of single-agent bendamustine in 27 heavily pretreated patients with relapsed or refractory Hodgkin's lymphoma, who had all received brentuximab vedotin as their last treatment and who showed disease progression, refractory disease, or early relapse. The primary study endpoint was the objective response rate, and the secondary endpoint was the safety of the bendamustine regimen. RESULTS: The overall response rate was 55.5%, with 10 of 27 patients (37.0%) obtaining a complete response. In comparison, the overall response rate previously observed with brentuximab vedotin in the same subset of patients was much lower (18.5%). Among the 10 patients with a complete response after bendamustine, only 1 had had a complete response to brentuximab, with 2 having a partial response and 7 stable or progressive disease. With a median duration of response of 8 months, all these patients had maintained a continuous response at the last follow-up examination. The treatment was well tolerated, with rather infrequent adverse events and transient and manageable toxicities. CONCLUSION: Albeit with the limits of an observational retrospective study, these data indicate that bendamustine shows its efficacy in patients already treated with brentuximab vedotin, regardless of their previously obtained response and without any significant toxicity.
BACKGROUND: The optimal treatment of patients with heavily pretreated Hodgkin's lymphoma is controversial. Brentuximab vedotin is an active single agent in this context. Also, bendamustine can be regarded as a safe and effective alternative for patients with relapse after autologous transplantation and as an interesting cytoreductive strategy before allogeneic transplantation. PATIENTS AND METHODS: An observational, multicenter, retrospective study is reported of single-agent bendamustine in 27 heavily pretreated patients with relapsed or refractory Hodgkin's lymphoma, who had all received brentuximab vedotin as their last treatment and who showed disease progression, refractory disease, or early relapse. The primary study endpoint was the objective response rate, and the secondary endpoint was the safety of the bendamustine regimen. RESULTS: The overall response rate was 55.5%, with 10 of 27 patients (37.0%) obtaining a complete response. In comparison, the overall response rate previously observed with brentuximab vedotin in the same subset of patients was much lower (18.5%). Among the 10 patients with a complete response after bendamustine, only 1 had had a complete response to brentuximab, with 2 having a partial response and 7 stable or progressive disease. With a median duration of response of 8 months, all these patients had maintained a continuous response at the last follow-up examination. The treatment was well tolerated, with rather infrequent adverse events and transient and manageable toxicities. CONCLUSION: Albeit with the limits of an observational retrospective study, these data indicate that bendamustine shows its efficacy in patients already treated with brentuximab vedotin, regardless of their previously obtained response and without any significant toxicity.
Authors: J El Cheikh; R Massoud; I Abudalle; B Haffar; R Mahfouz; M A Kharfan-Dabaja; T Jisr; A Mougharbel; A Ibrahim; A Bazarbachi Journal: Bone Marrow Transplant Date: 2017-04-10 Impact factor: 5.483
Authors: C Y Cheah; D Chihara; S Horowitz; A Sevin; Y Oki; S Zhou; N H Fowler; J E Romaguera; F Turturro; F B Hagemeister; L E Fayad; M Wang; S S Neelapu; L J Nastoupil; J R Westin; M A Rodriguez; F Samaniego; P Anderlini; Y Nieto; M A Fanale Journal: Ann Oncol Date: 2016-04-18 Impact factor: 32.976
Authors: A Broccoli; L Argnani; B Botto; P Corradini; A Pinto; A Re; U Vitolo; S Fanti; V Stefoni; P L Zinzani Journal: Blood Cancer J Date: 2019-12-11 Impact factor: 11.037