Christian H Dall1, Finn Gustafsson2, Stefan B Christensen3, Flemming Dela4, Henning Langberg5, Eva Prescott6. 1. Department of Cardiology, Bispebjerg Hospital, University of Copenhagen; Institute of Sports Medicine Copenhagen (ISMC/MRRU). Electronic address: christian.have.dall@regionh.dk. 2. Department of Cardiology, Heart Centre, Rigshospitalet, University of Copenhagen. 3. Department of Cardiology, Gentofte Hospital, University of Copenhagen. 4. Xlab, Center for Healthy Aging, University of Copenhagen. 5. CopenRehab, Department of Public Health, University of Copenhagen, Copenhagen, Denmark. 6. Department of Cardiology, Bispebjerg Hospital, University of Copenhagen.
Abstract
BACKGROUND: Growing evidence in long-term treatment of heart transplant (HTx) recipients indicates effects of high-intensity interval training (HIIT) on several parameters, including oxygen uptake, vascular function and psychological distress. In this study we compare the effect of HIIT vs continued moderate training (CON) on vascular function, biomarkers and health-related quality of life (HRQoL) in HTx recipients. METHODS: A randomized, controlled crossover trial of stable HTx recipients >12 months after transplantation was done on patients with 12 weeks of HIIT or 12 weeks ofCON, followed by a 5-month washout and crossover. Outcomes included endothelial function, arterial stiffness, biomarkers, HRQoL and markers of anxiety and depression. RESULTS:Sixteen HTx recipients (mean age 52 years, 75% male) completed the study. HIIT increased VO(2peak) more than CON (between-group difference, p < 0.001). The physical component score of the 36-item Short Form (SF-36) was increased significantly in HIIT patients (p = 0.02) and borderline increased in CON patients (p = 0.07), whereas there was no significant effect of exercise on the mental component. Depression score decreased significantly in HIIT patients (p = 0.04) with no change in CON patients (p = 0.75), whereas anxiety score decreased significantly in both HIIT (p < 0.01) and CON (p < 0.05) patients. There were no between-group differences in any of the measures (all p > 0.05). Arterial stiffness and biomarkers were not changed, nor did endothelial function change after HIIT (p = 0.08) or CON (p = 0.68). CONCLUSIONS: HIIT and CON are both well tolerated and induce similar improvements in physical components of HRQoL and in markers of anxiety. Effects of either training modality on vascular function and biomarkers could not be confirmed.
RCT Entities:
BACKGROUND: Growing evidence in long-term treatment of heart transplant (HTx) recipients indicates effects of high-intensity interval training (HIIT) on several parameters, including oxygen uptake, vascular function and psychological distress. In this study we compare the effect of HIIT vs continued moderate training (CON) on vascular function, biomarkers and health-related quality of life (HRQoL) in HTx recipients. METHODS: A randomized, controlled crossover trial of stable HTx recipients >12 months after transplantation was done on patients with 12 weeks of HIIT or 12 weeks of CON, followed by a 5-month washout and crossover. Outcomes included endothelial function, arterial stiffness, biomarkers, HRQoL and markers of anxiety and depression. RESULTS: Sixteen HTx recipients (mean age 52 years, 75% male) completed the study. HIIT increased VO(2peak) more than CON (between-group difference, p < 0.001). The physical component score of the 36-item Short Form (SF-36) was increased significantly in HIIT patients (p = 0.02) and borderline increased in CON patients (p = 0.07), whereas there was no significant effect of exercise on the mental component. Depression score decreased significantly in HIIT patients (p = 0.04) with no change in CON patients (p = 0.75), whereas anxiety score decreased significantly in both HIIT (p < 0.01) and CON (p < 0.05) patients. There were no between-group differences in any of the measures (all p > 0.05). Arterial stiffness and biomarkers were not changed, nor did endothelial function change after HIIT (p = 0.08) or CON (p = 0.68). CONCLUSIONS: HIIT and CON are both well tolerated and induce similar improvements in physical components of HRQoL and in markers of anxiety. Effects of either training modality on vascular function and biomarkers could not be confirmed.
Authors: Juliana Andrade Ferreira de Souza; Bruna T S Araújo; Gustavo Henrique Correia de Lima; Armèle Dornelas de Andrade; Shirley Lima Campos; Maria Inês Remígio de Aguiar; Rodrigo Moreno Dias Carneiro; Daniella Cunha Brandão Journal: Heart Fail Rev Date: 2020-05 Impact factor: 4.214
Authors: Lindsey Anderson; Tricia T Nguyen; Christian H Dall; Laura Burgess; Charlene Bridges; Rod S Taylor Journal: Cochrane Database Syst Rev Date: 2017-04-04
Authors: Roseanne E Billany; Alice C Smith; Ganisha M Hutchinson; Matthew P M Graham-Brown; Daniel G D Nixon; Nicolette C Bishop Journal: Pilot Feasibility Stud Date: 2022-05-21
Authors: Emily S Tonorezos; Jennifer S Ford; Linwei Wang; Kirsten K Ness; Yutaka Yasui; Wendy Leisenring; Charles A Sklar; Leslie L Robison; Kevin C Oeffinger; Paul C Nathan; Gregory T Armstrong; Kevin Krull; Lee W Jones Journal: Cancer Date: 2019-05-08 Impact factor: 6.921