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Literature DB >> 25839742

Multigenerational and transgenerational inheritance of drug exposure: The effects of alcohol, opiates, cocaine, marijuana, and nicotine.

Nicole L Yohn¹, Marisa S Bartolomei², Julie A Blendy³.

Abstract

Familial inheritance of drug abuse is composed of both genetic and environmental factors. Additionally, epigenetic transgenerational inheritance may provide a means by which parental drug use can influence several generations of offspring. Recent evidence suggests that parental drug exposure produces behavioral, biochemical, and neuroanatomical changes in future generations. The focus of this review is to discuss these multigenerational and transgenerational phenotypes in the offspring of animals exposed to drugs of abuse. Specifically, changes found following the administration of alcohol, opioids, cocaine, marijuana, and nicotine will be discussed. In addition, epigenetic modifications to the genome following administration of these drugs will be detailed as well as their potential for transmission to the next generation.

Entities: CellLine Chemical Disease Gene Mutation Species

Keywords: Drug abuse; Epigenetic; Multigenerational; Transgenerational

Mesh：

Substances：

Year: 2015 PMID： 25839742 PMCID： PMC4459901 DOI： 10.1016/j.pbiomolbio.2015.03.002

Source DB: PubMed Journal: Prog Biophys Mol Biol ISSN： 0079-6107 Impact factor: 3.667

148 in total

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Journal: J Neurosci Date: 2012-02-01 Impact factor: 6.167

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Authors: Henrietta Szutorisz; Jennifer A DiNieri; Eric Sweet; Gabor Egervari; Michael Michaelides; Jenna M Carter; Yanhua Ren; Michael L Miller; Robert D Blitzer; Yasmin L Hurd
Journal: Neuropsychopharmacology Date: 2014-01-02 Impact factor: 7.853

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Authors: L J van der Knaap; J M Schaefer; I H A Franken; F C Verhulst; F V A van Oort; H Riese
Journal: Genes Brain Behav Date: 2014-06-24 Impact factor: 3.449

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Authors: A Markou; G F Koob
Journal: Neuropsychopharmacology Date: 1991-01 Impact factor: 7.853

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Authors: Elizabeth M Byrnes
Journal: Psychopharmacology (Berl) Date: 2005-10-19 Impact factor: 4.530

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Authors: Yuzuru Kato; Masahiro Kaneda; Kenichiro Hata; Kenji Kumaki; Mizue Hisano; Yuji Kohara; Masaki Okano; En Li; Masami Nozaki; Hiroyuki Sasaki
Journal: Hum Mol Genet Date: 2007-07-06 Impact factor: 6.150

8. Delta9-tetrahydrocannabinol increases sequence-specific AP-1 DNA-binding activity and Fos-related antigens in the rat brain.

Authors: A Porcella; G L Gessa; L Pani
Journal: Eur J Neurosci Date: 1998-05 Impact factor: 3.386

9. BDNF-mediated regulation of ethanol consumption requires the activation of the MAP kinase pathway and protein synthesis.

Authors: Jerome Jeanblanc; Marian L Logrip; Patricia H Janak; Dorit Ron
Journal: Eur J Neurosci Date: 2012-11-28 Impact factor: 3.386

10. Epigenetic inheritance of a cocaine-resistance phenotype.

Authors: Fair M Vassoler; Samantha L White; Heath D Schmidt; Ghazaleh Sadri-Vakili; R Christopher Pierce
Journal: Nat Neurosci Date: 2012-12-16 Impact factor: 24.884

49 in total

1. Impaired cocaine-induced behavioral plasticity in the male offspring of cocaine-experienced sires.

Authors: Mathieu E Wimmer; Fair M Vassoler; Samantha L White; Heath D Schmidt; Simone Sidoli; Yumiao Han; Benjamin A Garcia; R Christopher Pierce
Journal: Eur J Neurosci Date: 2019-01-06 Impact factor: 3.386

2. Paternal nicotine exposure in rats produces long-lasting neurobehavioral effects in the offspring.

Authors: Andrew B Hawkey; Hannah White; Erica Pippen; Eva Greengrove; Amir H Rezvani; Susan K Murphy; Edward D Levin
Journal: Neurotoxicol Teratol Date: 2019-05-16 Impact factor: 3.763

3. Offspring of male rats exposed to binge alcohol exhibit heightened ethanol intake at infancy and alterations in T-maze performance.

Authors: Jessica Hollander; Megan McNivens; Ricardo M Pautassi; Michael E Nizhnikov
Journal: Alcohol Date: 2018-08-09 Impact factor: 2.405

4. Transgenerational blunting of morphine-induced corticosterone secretion is associated with dysregulated gene expression in male offspring.

Authors: Fair M Vassoler; Anika M Toorie; Elizabeth M Byrnes
Journal: Brain Res Date: 2017-11-10 Impact factor: 3.252