Literature DB >> 25839730

Differences in Evolution of HIV-1 Subtype C Reverse Transcriptase Between Children and Adults Likely Explained by Maturity of Cytotoxic T-Lymphocyte Responses.

Shanmugam Saravanan1, Selvamurthi Gomathi1, Bagavathi Kausalya1, Jayaseelan Boobalan1, Kailapuri G Murugavel1, Pachamuthu Balakrishnan1, Sarvode N Mothi2, Sunil S Solomon1,3, Nagalingeswaran Kumarasamy1, Poongulali Selvamuthu1, Suniti Solomon1, Davey M Smith4,5.   

Abstract

In this study HIV-1 subtype C-infected adults demonstrated higher purifying selection on their viral populations in reverse transcriptase (RT) than infected children. This difference is likely explained by more mature cytotoxic T-lymphocyte responses in adults, which may have implications for the development of drug resistance in the RT region.

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Year:  2015        PMID： 25839730      PMCID： PMC4458742          DOI： 10.1089/AID.2015.0023

Source DB:  PubMed          Journal:  AIDS Res Hum Retroviruses        ISSN： 0889-2229            Impact factor:   2.205


  14 in total

Review 1.  Paediatric HIV-1 infection.

Authors:  D N Burns; L M Mofenson
Journal:  Lancet       Date:  1999-09       Impact factor: 79.321

2.  HyPhy: hypothesis testing using phylogenies.

Authors:  Sergei L Kosakovsky Pond; Simon D W Frost; Spencer V Muse
Journal:  Bioinformatics       Date:  2004-10-27       Impact factor: 6.937

3.  A recombinant vaccinia virus based ELISPOT assay detects high frequencies of Pol-specific CD8 T cells in HIV-1-positive individuals.

Authors:  M Larsson; X Jin; B Ramratnam; G S Ogg; J Engelmayer; M A Demoitie; A J McMichael; W I Cox; R M Steinman; D Nixon; N Bhardwaj
Journal:  AIDS       Date:  1999-05-07       Impact factor: 4.177

Review 4.  Cytotoxic T-lymphocyte responses to HIV-1 reverse transcriptase (review).

Authors:  L Menéndez-Arias; A Mas; E Domingo
Journal:  Viral Immunol       Date:  1998       Impact factor: 2.257

5.  Evidence of HIV-1 adaptation to HLA-restricted immune responses at a population level.

Authors:  Corey B Moore; Mina John; Ian R James; Frank T Christiansen; Campbell S Witt; Simon A Mallal
Journal:  Science       Date:  2002-05-24       Impact factor: 47.728

Review 6.  Action of anti-HIV drugs and resistance: reverse transcriptase inhibitors and protease inhibitors.

Authors:  Tomozumi Imamichi
Journal:  Curr Pharm Des       Date:  2004       Impact factor: 3.116

7.  Identification of human immunodeficiency virus-1 specific CD8+ and CD4+ T cell responses in perinatally-infected infants and their mothers.

Authors:  Sharon Shalekoff; Stephen Meddows-Taylor; Glenda E Gray; Gayle G Sherman; Ashraf H Coovadia; Louise Kuhn; Caroline T Tiemessen
Journal:  AIDS       Date:  2009-04-27       Impact factor: 4.177

8.  Evaluation of two human immunodeficiency virus-1 genotyping systems: ViroSeq 2.0 and an in-house method.

Authors:  S Saravanan; M Vidya; P Balakrishnan; P Balakrishanan; N Kumarasamy; Sunil S Solomon; S Solomon; Rami Kantor; David Katzenstein; Bharat Ramratnam; Kenneth H Mayer
Journal:  J Virol Methods       Date:  2009-04-02       Impact factor: 2.014

Review 9.  Immune pathogenesis of pediatric HIV-1 infection.

Authors:  Caroline T Tiemessen; Louise Kuhn
Journal:  Curr HIV/AIDS Rep       Date:  2006-02       Impact factor: 5.071

10.  A standardized framework for accurate, high-throughput genotyping of recombinant and non-recombinant viral sequences.

Authors:  Luiz Carlos Junior Alcantara; Sharon Cassol; Pieter Libin; Koen Deforche; Oliver G Pybus; Marc Van Ranst; Bernardo Galvão-Castro; Anne-Mieke Vandamme; Tulio de Oliveira
Journal:  Nucleic Acids Res       Date:  2009-05-29       Impact factor: 16.971
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