A D Bhagat Singh1, Swapan Majumdar2, Amal Kanti Ghosh3, Lakshmi Gandi4, Nidhi Choudaha5, Ipsita Sharma5, S P Pal6. 1. Department of Oral Surgery, Mithala Minority Dental College and Hospital, Mansukh Nagar, Darbhanga, Bihar, India. 2. Department of Prosthodontics, Mithala Minority Dental College and Hospital, Mansukh Nagar, Darbhanga, Bihar, India. 3. Department of Conservative Dentistry, Mithala Minority Dental College and Hospital, Mansukh Nagar, Darbhanga, Bihar, India. 4. Department of Oral and Maxillofacial Surgery, Vyas Dental College and Hospital, Jodhpur, Rajasthan, India. 5. Department of Oral Pathology, RKDF Dental College and Research Center, Bhopal, Madhya Pradesh, India. 6. Department of Orthodontics, Mithala Minority Dental College and Hospital, Mansukh Nagar, Darbhanga, Bihar, India.
Abstract
INTRODUCTION: Basal cell adenoma (BCA) of the salivary glands is a rare benign salivary gland tumour. Differentiation of BCA from varied entities involving maxillofacial area is mandatory. AIM: To analyze the clinicopathological, histopathologic features, immunohistochemcal analysis and surgical considerations of this rare entity. MATERIALS AND METHODS: This study included 12 cases of BCA from archives of department reported over the period of 13 years. All the pertaining clinicopathologic features such as incidence, age, sex and site of lesions were assessed. Tissue sections were stained by using panel of immunohistochemical markers, i.e. Pan CK, CK 5/6 and S100, Calponin, p63, CD 117 and smooth muscle actin. RESULTS: BCA was observed in 26-52 years age group (mean age, 38.75 years) with female propensity of 7:5 male to female ratio. It is seen more commonly in parotid gland, followed by upper lip, buccal mucosa and palate. Solid type is the most common histopathologic type followed by tubular, membranous and trabecular. Only one case of membranous type of BCA showed recurrence. Pan CK, CK 5/6 showed strong immunoreactivity, calponin showed moderate staining, p63 and Ki-67 mild staining, whereas CD 117 and SMA showed negative immunostaining. CONCLUSION: Vigilant comprehensive analysis of all the pertaining clinicopathologic and histopathologic features and immunohistochemical analysis are required for differentiating from other lesions with basaloid differentiation having varying prognosis.
INTRODUCTION:Basal cell adenoma (BCA) of the salivary glands is a rare benign salivary gland tumour. Differentiation of BCA from varied entities involving maxillofacial area is mandatory. AIM: To analyze the clinicopathological, histopathologic features, immunohistochemcal analysis and surgical considerations of this rare entity. MATERIALS AND METHODS: This study included 12 cases of BCA from archives of department reported over the period of 13 years. All the pertaining clinicopathologic features such as incidence, age, sex and site of lesions were assessed. Tissue sections were stained by using panel of immunohistochemical markers, i.e. Pan CK, CK 5/6 and S100, Calponin, p63, CD 117 and smooth muscle actin. RESULTS:BCA was observed in 26-52 years age group (mean age, 38.75 years) with female propensity of 7:5 male to female ratio. It is seen more commonly in parotid gland, followed by upper lip, buccal mucosa and palate. Solid type is the most common histopathologic type followed by tubular, membranous and trabecular. Only one case of membranous type of BCA showed recurrence. Pan CK, CK 5/6 showed strong immunoreactivity, calponin showed moderate staining, p63 and Ki-67 mild staining, whereas CD 117 and SMA showed negative immunostaining. CONCLUSION: Vigilant comprehensive analysis of all the pertaining clinicopathologic and histopathologic features and immunohistochemical analysis are required for differentiating from other lesions with basaloid differentiation having varying prognosis.
Authors: J C De Vicente Rodriguez; J S Lopez Arranz; L M Junquera Gutierrez; I Alvarez Alvarez; M J Garcia-Pola Vallejo Journal: Rev Eur Odontoestomatol Date: 1991 Sep-Oct
Authors: Mirna Scalon Cordeiro; Silas Antonio Juvencio de Freitas Filho; João Paulo Silva Servato; Ana Lúcia Amaral Eisenberg; Fernando Luiz Dias; Paulo Rogério de Faria; Adriano Mota Loyola; Sérgio Vitorino Cardoso Journal: Eur Arch Otorhinolaryngol Date: 2020-09-04 Impact factor: 2.503