Literature DB >> 25837497

Bilateral primary adrenal non-Hodgkin's lymphoma without adrenal insufficiency.

William Greg Simpson1, Paurush Babbar2, Lynnetta Faith Payne3.   

Abstract

We are presenting a rare case of bilateral adrenal non-Hodgkin's lymphoma (NHL) that presented as a primary malignancy. An 83-year-old man presented with newly discovered bilateral adrenal incidentalomas, fatigue, and 30 pound weight loss. Of the 116 cases of primary adrenal NHL reported, over half have presented bilaterally and occur with adrenal insufficiency. Therefore, the finding of bilateral adrenal masses requires an urgent work-up of the functional status of the adrenal gland as well as a thorough analysis of the imaging characteristics seen on noncontrast computed tomography (CT) in order to maximize patient survival. Adrenal function testing was normal. Repeat CT imaging revealed rapidly growing lesions with high attenuations; both masses >10 HU. Histological examination of core biopsies discovered malignant lymphoma with no known past history of lymphoma. Our case coincides with the literature, which states that a mass with attenuation >10 HU in the adrenal glands has a high risk of malignancy.

Entities:  

Keywords:  Extranodal; incidentaloma; primary non-Hodgkin's lymphoma

Year:  2015        PMID: 25837497      PMCID: PMC4374272          DOI: 10.4103/0974-7796.152942

Source DB:  PubMed          Journal:  Urol Ann        ISSN: 0974-7796


  10 in total

1.  Primary adrenal lymphoma presented with adrenal insufficiency.

Authors:  Evanthia Diamanti-Kandarakis; Pantelis Chatzismalis; Frangiskos Economou; Stefanos Lazarides; Athena Androulaki; Grigorios Kouraklis
Journal:  Hormones (Athens)       Date:  2004 Jan-Mar       Impact factor: 2.885

Review 2.  Bilateral adrenal non-Hodgkin's lymphoma with adrenal insufficiency.

Authors:  R D Ellis; D Read
Journal:  Postgrad Med J       Date:  2000-08       Impact factor: 2.401

3.  Metastases to the adrenal glands and the development of Addison's disease.

Authors:  D J Seidenwurm; E B Elmer; L M Kaplan; E K Williams; D G Morris; A R Hoffman
Journal:  Cancer       Date:  1984-08-01       Impact factor: 6.860

4.  Adrenal incidentaloma: an overview of clinical and epidemiological data from the National Italian Study Group.

Authors:  A Angeli; G Osella; A Alì; M Terzolo
Journal:  Horm Res       Date:  1997

5.  Non-Hodgkin's lymphoma presenting with primary adrenal insufficiency. A disease with an underestimated frequency?

Authors:  E Gamelin; V Beldent; M C Rousselet; D Rieux; V Rohmer; N Ifrah; M Boasson; J C Bigorgne
Journal:  Cancer       Date:  1992-05-01       Impact factor: 6.860

6.  Management of the clinically inapparent adrenal mass ("incidentaloma").

Authors:  Melvin M Grumbach; Beverly M K Biller; Glenn D Braunstein; Karen K Campbell; J Aidan Carney; Paul A Godley; Emily L Harris; Joseph K T Lee; Yolanda C Oertel; Mitchell C Posner; Janet A Schlechte; H Samuel Wieand
Journal:  Ann Intern Med       Date:  2003-03-04       Impact factor: 25.391

7.  Clinical utility of noncontrast computed tomography attenuation value (hounsfield units) to differentiate adrenal adenomas/hyperplasias from nonadenomas: Cleveland Clinic experience.

Authors:  Amir H Hamrahian; Adriana G Ioachimescu; Erick M Remer; Gaspar Motta-Ramirez; Hari Bogabathina; Howard S Levin; Sethu Reddy; Inderbir S Gill; Allan Siperstein; Emmanuel L Bravo
Journal:  J Clin Endocrinol Metab       Date:  2004-11-30       Impact factor: 5.958

8.  High grade primary adrenal intravascular large B-cell lymphoma manifesting as Addison disease.

Authors:  I Venizelos; J Venizelos; D Tamiolakis; M Lambropoulou; G Alexiadis; G Petrakis; N Papadopoulos
Journal:  Rev Esp Enferm Dig       Date:  2007-08       Impact factor: 2.086

Review 9.  Bilateral primary adrenal non-Hodgkin's lymphoma and primary adrenocortical carcinoma--review of the literature preoperative differentiation of adrenal tumors.

Authors:  Alexandra Ozimek; Joachim Diebold; Rainer Linke; Jens Heyn; Klaus Hallfeldt; Thomas Mussack
Journal:  Endocr J       Date:  2008-05-19       Impact factor: 2.349

10.  Primary adrenal lymphoma: Differential involvement with varying adrenal function.

Authors:  Shiekh Aejaz Aziz; Bashir Ahmad Laway; Imran Rangreze; Mohd Iqbal Lone; Syed Nisar Ahmad
Journal:  Indian J Endocrinol Metab       Date:  2011-07
  10 in total
  2 in total

1.  Rare cause of adrenal insufficiency.

Authors:  Justin Ws Hii; Michael M Page; Andrew Wesseldine
Journal:  BMJ Case Rep       Date:  2017-11-16

2.  Bilateral primary adrenal lymphoma with adrenal insufficiency.

Authors:  Aishah Ekhzaimy; Ahmad Mujamammi
Journal:  BMJ Case Rep       Date:  2016-10-26
  2 in total

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