Literature DB >> 25837444

Enhancement of memory consolidation by the histone deacetylase inhibitor sodium butyrate in aged rats.

Martina Blank1, Aline Werenicz2, Luciana Azevedo Velho3, Diana F Pinto3, Ana Cláudia Fedi3, Mark William Lopes4, Tanara Vieira Peres4, Rodrigo Bainy Leal4, Arethuza S Dornelles2, Rafael Roesler5.   

Abstract

Here we show that a systemic injection of the histone deacetylase inhibitor (HDACi) sodium butyrate (NaB) immediately after training in a step-down inhibitory avoidance task produced an enhancement of memory consolidation that persisted across consecutive retention tests during 14 days in aged rats, while it did not significantly affect memory in young adults. Control aged and young adult rats showed comparable basal levels of memory retention. Our results suggest that HDACis can display memory-enhancing effects specific for aged animals, even in the absence of age-related memory impairment.
Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Entities:  

Keywords:  Epigenetics; Histone deacetylase; Inhibitory avoidance; Memory consolidation; Sodium butyrate

Mesh：

Substances：

Year:  2015        PMID： 25837444     DOI： 10.1016/j.neulet.2015.03.059

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  5 in total

Review 1.  The Gut Microbiota and Healthy Aging: A Mini-Review.

Authors:  Sangkyu Kim; S Michal Jazwinski
Journal:  Gerontology       Date:  2018-07-19       Impact factor: 5.140

2.  TrkB blockade in the hippocampus after training or retrieval impairs memory: protection from consolidation impairment by histone deacetylase inhibition.

Authors:  Martina Blank; Fernanda S Petry; Martina Lichtenfels; Fernanda E Valiati; Arethuza S Dornelles; Rafael Roesler
Journal:  J Neural Transm (Vienna)       Date:  2015-10-01       Impact factor: 3.575

3.  Administration of a Histone Deacetylase Inhibitor into the Basolateral Amygdala Enhances Memory Consolidation, Delays Extinction, and Increases Hippocampal BDNF Levels.

Authors:  Fernanda E Valiati; Mailton Vasconcelos; Martina Lichtenfels; Fernanda S Petry; Rosa M M de Almeida; Gilberto Schwartsmann; Nadja Schröder; Caroline B de Farias; Rafael Roesler
Journal:  Front Pharmacol       Date:  2017-06-28       Impact factor: 5.810

Review 4.  Stress and the Emerging Roles of Chromatin Remodeling in Signal Integration and Stable Transmission of Reversible Phenotypes.

Authors:  Ian C G Weaver; Austin C Korgan; Kristen Lee; Ryan V Wheeler; Amos S Hundert; Donna Goguen
Journal:  Front Behav Neurosci       Date:  2017-03-15       Impact factor: 3.558

5.  Butyrate and Dietary Soluble Fiber Improve Neuroinflammation Associated With Aging in Mice.

Authors:  Stephanie M Matt; Jacob M Allen; Marcus A Lawson; Lucy J Mailing; Jeffrey A Woods; Rodney W Johnson
Journal:  Front Immunol       Date:  2018-08-14       Impact factor: 7.561
  5 in total

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