Miae Doo1, Sungho Won2, Yangha Kim3. 1. Department of Nutritional Science and Food Management, Ewha Womans University, Ewhayeodae-gil, Seoul, Korea. 2. Department of Public Health Science, School of Public Health, Seoul National University, Kwanak-ro, Seoul, Korea. 3. Department of Nutritional Science and Food Management, Ewha Womans University, Ewhayeodae-gil, Seoul, Korea. Electronic address: yhmoon@ewha.ac.kr.
Abstract
OBJECTIVE: The apolipoprotein B (APOB) gene has been reported to be a candidate gene for individual susceptibility to dyslipidemia and obesity. The aim of this study was to investigate the effect of the APOB rs1469513 polymorphism on plasma lipid profiles and obesity-related phenotypes, together with their modulation by dietary intake in Korean individuals. METHODS: We analyzed the plasma lipid profiles, obesity-related phenotypes, and dietary intake of 6470 Korean aged 40 to 59 y from the KoGES (Korean Genome Epidemiology Study) database. The effects of APOB rs1469513 on traits, the interaction of APOB rs1469513 and dietary intake on traits were analyzed. RESULTS: Plasma levels of total cholesterol (P = 0.001) and low-density lipoprotein cholesterol (P = 0.010), body weight (P = 0.048), and body mass index (P = 0.029) were significantly different in carriers of the A allele and minor G allele of APOB rs1469513. Among individuals whose fat intake was above the median, the difference for the body mass index across genotypes is 1.14% (AA 24.66 kg/m(2) versus AG+GG 24.94 kg/m(2), P = 0.004) and carriers of the minor G allele had increased odds of being obese (Odds ratios, 1.31; 95% confidence interval, 1.09-1.57; P = 0.004) compared with homozygotes for the A allele. CONCLUSIONS: Our findings support a significant association between the APOB rs1469513 variant, plasma lipid profiles, and obesity-related phenotypes. This association has the potential to be modified by dietary fat intake. These results may offer proof that the differences between normal weight and overweight/obese individuals might partly result from different SNPs.
OBJECTIVE: The apolipoprotein B (APOB) gene has been reported to be a candidate gene for individual susceptibility to dyslipidemia and obesity. The aim of this study was to investigate the effect of the APOBrs1469513 polymorphism on plasma lipid profiles and obesity-related phenotypes, together with their modulation by dietary intake in Korean individuals. METHODS: We analyzed the plasma lipid profiles, obesity-related phenotypes, and dietary intake of 6470 Korean aged 40 to 59 y from the KoGES (Korean Genome Epidemiology Study) database. The effects of APOBrs1469513 on traits, the interaction of APOBrs1469513 and dietary intake on traits were analyzed. RESULTS: Plasma levels of total cholesterol (P = 0.001) and low-density lipoprotein cholesterol (P = 0.010), body weight (P = 0.048), and body mass index (P = 0.029) were significantly different in carriers of the A allele and minor G allele of APOBrs1469513. Among individuals whose fat intake was above the median, the difference for the body mass index across genotypes is 1.14% (AA 24.66 kg/m(2) versus AG+GG 24.94 kg/m(2), P = 0.004) and carriers of the minor G allele had increased odds of being obese (Odds ratios, 1.31; 95% confidence interval, 1.09-1.57; P = 0.004) compared with homozygotes for the A allele. CONCLUSIONS: Our findings support a significant association between the APOBrs1469513 variant, plasma lipid profiles, and obesity-related phenotypes. This association has the potential to be modified by dietary fat intake. These results may offer proof that the differences between normal weight and overweight/obese individuals might partly result from different SNPs.
Authors: R Alan Harris; Callison E Alcott; Elinor L Sullivan; Diana Takahashi; Carrie E McCurdy; Sarah Comstock; Karalee Baquero; Peter Blundell; Antonio E Frias; Maike Kahr; Melissa Suter; Stephanie Wesolowski; Jacob E Friedman; Kevin L Grove; Kjersti M Aagaard Journal: Sci Rep Date: 2016-11-04 Impact factor: 4.379
Authors: Mohammad M H Abdullah; Itzel Vazquez-Vidal; David J Baer; James D House; Peter J H Jones; Charles Desmarchelier Journal: Nutrients Date: 2021-02-22 Impact factor: 5.717