Rennan Feng1, Yanchuan Li1, Guoqiang Li2, Zhen Li1, Yingfeng Zhang1, Qiang Li3, Changhao Sun4. 1. Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, China; National Key Discipline, Harbin Medical University, Harbin, China. 2. Dean Office, Harbin Medical University, Harbin, China. 3. Department of Endocrinology, Second Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address: liqiang_hmu@126.com. 4. Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, China; National Key Discipline, Harbin Medical University, Harbin, China. Electronic address: changhao2002sun@gmail.com.
Abstract
OBJECTIVE: Vitamin D may have protective effects against type 1 diabetes (T1D). However, the results of current cross-sectional studies have been inconsistent. We aimed to examine the association of serum vitamin D and T1D by conducting a meta-analysis. METHODS: Multiple databases were searched until April 2014 to identify relevant studies. The search term was "serum vitamin D" and "type 1 diabetes". Random effects model was used to calculate the pooled risk estimate. The data were accessed by software Review manager 5.2. RESULTS: We included a total of 23 studies (11 studies with 1900 participants of children or adolescents and 13 studies with 3494 participants of adults) in our meta-analysis. In children or adolescents, serum 25(OH) D in T1D was 5.69 ng/ml [95% confidence interval (CI) (2.82-8.55, P<0.0001) lower than in healthy controls. In adults, serum 25(OH) D in T1D was 2.61 ng/ml [95% confidence interval (CI) (1.13-4.09, P=0.0005) lower than in healthy controls. We did not find evidence of publication bias. CONCLUSION: Serum 25OHD is significantly lower in patients with T1D than in healthy controls.
OBJECTIVE:Vitamin D may have protective effects against type 1 diabetes (T1D). However, the results of current cross-sectional studies have been inconsistent. We aimed to examine the association of serum vitamin D and T1D by conducting a meta-analysis. METHODS: Multiple databases were searched until April 2014 to identify relevant studies. The search term was "serum vitamin D" and "type 1 diabetes". Random effects model was used to calculate the pooled risk estimate. The data were accessed by software Review manager 5.2. RESULTS: We included a total of 23 studies (11 studies with 1900 participants of children or adolescents and 13 studies with 3494 participants of adults) in our meta-analysis. In children or adolescents, serum 25(OH) D in T1D was 5.69 ng/ml [95% confidence interval (CI) (2.82-8.55, P<0.0001) lower than in healthy controls. In adults, serum 25(OH) D in T1D was 2.61 ng/ml [95% confidence interval (CI) (1.13-4.09, P=0.0005) lower than in healthy controls. We did not find evidence of publication bias. CONCLUSION: Serum 25OHD is significantly lower in patients with T1D than in healthy controls.
Authors: Giuseppe Saggese; Francesco Vierucci; Flavia Prodam; Fabio Cardinale; Irene Cetin; Elena Chiappini; Gian Luigi De' Angelis; Maddalena Massari; Emanuele Miraglia Del Giudice; Michele Miraglia Del Giudice; Diego Peroni; Luigi Terracciano; Rino Agostiniani; Domenico Careddu; Daniele Giovanni Ghiglioni; Gianni Bona; Giuseppe Di Mauro; Giovanni Corsello Journal: Ital J Pediatr Date: 2018-05-08 Impact factor: 2.638
Authors: I M Talaat; A Nasr; A A Alsulaimani; H Alghamdi; K A Alswat; D M Almalki; A Abushouk; A M Saleh; G Allam Journal: J Endocrinol Invest Date: 2016-08-19 Impact factor: 4.256
Authors: A Legitimo; V Bertini; G Costagliola; G I Baroncelli; R Morganti; A Valetto; R Consolini Journal: Clin Exp Immunol Date: 2020-04-16 Impact factor: 4.330