Literature DB >> 25836733

Negative regulation of hepatitis B virus replication by forkhead box protein A in human hepatoma cells.

Nobuaki Okumura1, Masanori Ikeda2, Shinya Satoh3, Hiromichi Dansako3, Masaya Sugiyama4, Masashi Mizokami4, Nobuyuki Kato3.   

Abstract

Hepatitis B virus (HBV) replication is controlled by liver-enriched transcriptional factors, including forkhead box protein A (FOXA) members. Here, we found that FOXA members are directly and indirectly involved in HBV replication in human hepatic cells. HBV replication was elevated in HuH-7 treated with individual FOXA members-specific siRNA. Reciprocally, the downregulation of HBV replication was observed in FOXA-induced HuH-7. However, the mechanism of downregulation is different among FOXA members at the level of HBV RNA transcription, such as precore/pg RNA and 2.1 kb RNA. In addition, FOXA1 and FOXA2 suppressed nuclear hormone receptors, such as HNF4α, that are related to HBV replication.
Copyright © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Entities:  

Keywords:  FOXA1; FOXA2; FOXA3; HNF3; Hepatitis B virus; Hepatitis B virus replication

Mesh：

Substances：

Year:  2015        PMID： 25836733     DOI： 10.1016/j.febslet.2015.03.022

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  4 in total

1.  Phosphoproteomics to Characterize Host Response During Influenza A Virus Infection of Human Macrophages.

Authors:  Sandra Söderholm; Denis E Kainov; Tiina Öhman; Oxana V Denisova; Bert Schepens; Evgeny Kulesskiy; Susumu Y Imanishi; Garry Corthals; Petteri Hintsanen; Tero Aittokallio; Xavier Saelens; Sampsa Matikainen; Tuula A Nyman
Journal:  Mol Cell Proteomics       Date:  2016-08-02       Impact factor: 5.911

2.  Multiple antiviral activities of the antimalarial and anti-hepatitis C drug candidates N-89 and N-251.

Authors:  Youki Ueda; Weilin Gu; Hiromichi Dansako; Hye-Sook Kim; Sayaka Yoshizaki; Nobuaki Okumura; Tomohiro Ishikawa; Hironori Nishitsuji; Fumihiro Kato; Takayuki Hishiki; Shinya Satoh; Koji Ishii; Michiaki Masuda; Kunitada Shimotohno; Masanori Ikeda; Nobuyuki Kato
Journal:  Biochem Biophys Rep       Date:  2018-06-01

3.  m6A RNA methylation-mediated HNF3γ reduction renders hepatocellular carcinoma dedifferentiation and sorafenib resistance.

Authors:  Tengfei Zhou; Shichao Li; Daimin Xiang; Junyu Liu; Wen Sun; Xiuliang Cui; Beifang Ning; Xiao Li; Zhuo Cheng; Weiqi Jiang; Cheng Zhang; Xijun Liang; Liang Li; Xin Cheng; Liu Hui; Hongyang Wang; Jin Ding
Journal:  Signal Transduct Target Ther       Date:  2020-12-26

4.  Inhibiting roles of FOXA2 in liver cancer cell migration and invasion by transcriptionally suppressing microRNA-103a-3p and activating the GREM2/LATS2/YAP axis.

Authors:  Guangzhen Ma; Jirong Chen; Tiantian Wei; Jia Wang; Wenshan Chen
Journal:  Cytotechnology       Date:  2021-05-26       Impact factor: 2.040
  4 in total

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