| Literature DB >> 25836031 |
Roland Wohlgemuth1, Igor Plazl2, Polona Žnidaršič-Plazl2, Krist V Gernaey3, John M Woodley3.
Abstract
Despite the expanding presence of microscale technology in chemical synthesis and energy production as well as in biomedical devices and analytical and diagnostic tools, its potential in biocatalytic processes for pharmaceutical and fine chemicals, as well as related industries, has not yet been fully exploited. The aim of this review is to shed light on the strategic advantages of this promising technology for the development and realization of biocatalytic processes and subsequent product recovery steps, demonstrated with examples from the literature. Constraints, opportunities, and the future outlook for the implementation of these key green engineering methods and the role of supporting tools such as mathematical models to establish sustainable production processes are discussed.Keywords: biocatalytic process; enzymatic microreactors; flow synthesis; microscale technology; miniaturized production; process intensification
Mesh：
Year: 2015 PMID： 25836031 DOI： 10.1016/j.tibtech.2015.02.010
Source DB: PubMed Journal: Trends Biotechnol ISSN： 0167-7799 Impact factor: 19.536