PURPOSE: To determine the minimum apparent diffusion coefficient (ADC(min)) values of benign and malignant hepatic lesions based on diffusion-weighted imaging and to compare the diagnostic performance of ADC(min) and mean ADC (ADC(mean)) values for differentiating between benign and malignant tumors of the liver. MATERIALS AND METHODS: We retrospectively subjected 240 patients with 195 malignant (hepatocellular carcinoma [HCC], n = 137; metastases, n = 44; cholangiocellular carcinoma [CCC], n = 14) and 45 benign tumors (hemangiomas, n = 37; focal nodular hyperplasia [FNH], n = 8). Both ADC(mean) and ADC(min) were evaluated independently by 2 readers, the sensitivity and specificity for the detection of malignancy were calculated, and receiver operating characteristic (ROC) curves were generated. To determine interobserver agreement, we calculated the Pearson correlation coefficient. RESULTS: Mean ADC (×10 mm/s) was 1.19 for malignant (HCC, 1.15; metastasis, 1.23; CCC, 1.51) and 2.01 for benign tumors (hemangioma, 2.09; FNH, 1.52; P < 0.001). Minimum ADC was 0.81 for malignant (HCC, 0.79; metastasis, 0.81; CCC, 0.91) and 1.62 for benign tumors (hemangioma, 1.66; FNH, 1.28; P < 0.001). The sensitivity, specificity, and the calculated area under the ROC curve for diagnosing malignant lesions were 86.2%, 86.7%, and 0.942 (reader 1) and 88.7%, 88.9%, and 0.939 (reader 2) for ADC(mean); they were of 92.3%, 97.8%, and 0.984 (reader 1) and 94.9%, 97.8%, and 0.983 (reader 2) for ADC(min). CONCLUSIONS: Mean ADC and ADC(min) were valuable for differentiating between malignant and benign hepatic lesions. The area under the ROC curve of ADC(min) was significant higher than that of ADC(mean).
PURPOSE: To determine the minimum apparent diffusion coefficient (ADC(min)) values of benign and malignant hepatic lesions based on diffusion-weighted imaging and to compare the diagnostic performance of ADC(min) and mean ADC (ADC(mean)) values for differentiating between benign and malignant tumors of the liver. MATERIALS AND METHODS: We retrospectively subjected 240 patients with 195 malignant (hepatocellular carcinoma [HCC], n = 137; metastases, n = 44; cholangiocellular carcinoma [CCC], n = 14) and 45 benign tumors (hemangiomas, n = 37; focal nodular hyperplasia [FNH], n = 8). Both ADC(mean) and ADC(min) were evaluated independently by 2 readers, the sensitivity and specificity for the detection of malignancy were calculated, and receiver operating characteristic (ROC) curves were generated. To determine interobserver agreement, we calculated the Pearson correlation coefficient. RESULTS: Mean ADC (×10 mm/s) was 1.19 for malignant (HCC, 1.15; metastasis, 1.23; CCC, 1.51) and 2.01 for benign tumors (hemangioma, 2.09; FNH, 1.52; P < 0.001). Minimum ADC was 0.81 for malignant (HCC, 0.79; metastasis, 0.81; CCC, 0.91) and 1.62 for benign tumors (hemangioma, 1.66; FNH, 1.28; P < 0.001). The sensitivity, specificity, and the calculated area under the ROC curve for diagnosing malignant lesions were 86.2%, 86.7%, and 0.942 (reader 1) and 88.7%, 88.9%, and 0.939 (reader 2) for ADC(mean); they were of 92.3%, 97.8%, and 0.984 (reader 1) and 94.9%, 97.8%, and 0.983 (reader 2) for ADC(min). CONCLUSIONS: Mean ADC and ADC(min) were valuable for differentiating between malignant and benign hepatic lesions. The area under the ROC curve of ADC(min) was significant higher than that of ADC(mean).
Authors: Alexander W Sauter; Bram Stieltjes; Thomas Weikert; Sergios Gatidis; Mark Wiese; Markus Klarhöfer; Damian Wild; Didier Lardinois; Jens Bremerich; Gregor Sommer Journal: Contrast Media Mol Imaging Date: 2017-12-17 Impact factor: 3.161
Authors: Temel Fatih Yilmaz; Mehmet Ali Gultekin; Hacı Mehmet Turk; Mehmet Besiroglu; Dilek Hacer Cesme; Melih Simsek; Alpay Alkan; Huseyin Toprak Journal: Radiol Oncol Date: 2021-12-22 Impact factor: 2.991