Literature DB >> 25835608

"Seek, Test, Treat" Lessons From Australia: A Study of HIV Testing Patterns From a Cohort of Men Who Have Sex With Men.

Anna Lee Wilkinson1, Carol El-Hayek, Tim Spelman, Christopher Fairley, David Leslie, Emma McBryde, Margaret Hellard, Mark Stoové.   

Abstract

OBJECTIVE: HIV diagnoses are increasing in Australia, mostly among men who have sex with men (MSM). Similar to many countries, Australia's HIV prevention strategies emphasize a "seek, test, treat" approach including enhancing HIV testing frequency. We describe HIV testing among MSM and correlates of returning for testing within 12 months in the context of new HIV prevention paradigms.
METHODS: Testing and behavioral data (2007-2013) contributed by MSM aged ≥ 16 years were included. Total HIV tests by calendar year and repeat tests within 12 months were described, alongside negative binomial regression for trend. A 2-level mixed-effects logistic regression model examined correlates of testing within 12 months. Median (days) between HIV tests was compared between MSM diagnosed with HIV and persistently HIV-negative MSM.
RESULTS: The study included 46,060 tests from 17,904 MSM. There was an increase in annual tests (P < 0.01), repeat tests within 12 months (P < 0.01), and the proportion of tests within 12 months of an index test (P < 0.01), although only to 53.3% in 2013. Return rates were higher in MSM aged 16-29 years (adjusted odds ratio 1.30, 95% confidence interval: 1.1 to 1.5) and those reporting higher numbers of partners (adjusted odds ratio 3.5, 95% confidence interval: 3.0 to 4.0). Median time between tests among MSM diagnosed with HIV (233 days) was greater than for HIV-negative MSM (189 days) (P = 0.03).
CONCLUSIONS: Although testing has increased, testing frequency among many MSM remains suboptimal. To optimize "seek, test, treat"-based HIV prevention strategies, new approaches to increase testing uptake and early HIV detection among MSM are needed.

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Year:  2015        PMID: 25835608     DOI: 10.1097/QAI.0000000000000613

Source DB:  PubMed          Journal:  J Acquir Immune Defic Syndr        ISSN: 1525-4135            Impact factor:   3.731


  6 in total

1.  Evidence for optimal HIV screening and testing intervals in HIV-negative individuals from various risk groups: A systematic review.

Authors:  K Timmerman; M Weekes; G Traversy; P Prabakhar; T Austin; S Ha; B Anwar
Journal:  Can Commun Dis Rep       Date:  2018-12-06

2.  Acceptability and HIV Prevention Benefits of a Peer-Based Model of Rapid Point of Care HIV Testing for Australian Gay, Bisexual and Other Men Who Have Sex with Men.

Authors:  David Leitinger; Kathleen E Ryan; Graham Brown; Alisa Pedrana; Anna L Wilkinson; Claire Ryan; Margaret Hellard; Mark Stoové
Journal:  AIDS Behav       Date:  2018-01

3.  Undiagnosed HIV infections among gay and bisexual men increasingly contribute to new infections in Australia.

Authors:  Richard T Gray; David P Wilson; Rebecca J Guy; Mark Stoové; Margaret E Hellard; Garrett P Prestage; Toby Lea; John de Wit; Martin Holt
Journal:  J Int AIDS Soc       Date:  2018-04       Impact factor: 5.396

4.  Protocol for an HIV Pre-exposure Prophylaxis (PrEP) Population Level Intervention Study in Victoria Australia: The PrEPX Study.

Authors:  Kathleen E Ryan; Anne Mak; Mark Stoove; Brian Price; Christopher K Fairley; Simon Ruth; Luxshimi Lal; Jason Asselin; Carol El-Hayek; Long Nguyen; Colin Batrouney; David Wilson; John Lockwood; Dean Murphy; Vincent J Cornelisse; Norman Roth; Jeff Willcox; Christina C Chang; Judy Armishaw; Ban K Tee; Matthew Penn; George Forgan-Smith; Christopher Williams; Jeff Montgomery; Kat Byron; Alison Coelho; Brent Allen; Jeremy Wiggins; Jenny Kelsall; Olga Vujovic; Michael West; Anna B Pierce; Daniel Gallant; Charlotte Bell; John B F de Wit; Jennifer F Hoy; Steve L Wesselingh; Robert M Grant; Edwina J Wright
Journal:  Front Public Health       Date:  2018-05-29

5.  Trial and error: evaluating and refining a community model of HIV testing in Australia.

Authors:  Kathleen E Ryan; Alisa Pedrana; David Leitinger; Anna L Wilkinson; Peter Locke; Margaret E Hellard; Mark Stoové
Journal:  BMC Health Serv Res       Date:  2017-10-10       Impact factor: 2.655

6.  Molecular dynamic simulations to investigate the structural impact of known drug resistance mutations on HIV-1C Integrase-Dolutegravir binding.

Authors:  Rumbidzai Chitongo; Adetayo Emmanuel Obasa; Sello Given Mikasi; Graeme Brendon Jacobs; Ruben Cloete
Journal:  PLoS One       Date:  2020-05-07       Impact factor: 3.240

  6 in total

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