Literature DB >> 25833343

Optical measurement of mouse strain differences in cerebral blood flow using indocyanine green.

Hye-Min Kang1, Inkyung Sohn1, Seunggyu Kim2, Daehwan Kim2, Junyang Jung1, Joo-Won Jeong1, Chan Park1.   

Abstract

C57BL/6 mice have more cerebral arterial branches and collaterals than BALB/c mice. We measured and compared blood flow dynamics of the middle cerebral artery (MCA) in these two strains, using noninvasive optical imaging with indocyanine green (ICG). Relative maximum fluorescence intensity (Imax) and the time needed for ICG to reach Imax in the MCA of C57BL/c were lower than that in BALB/c mice. Moreover, the mean transit time was significantly lower in C57BL/6 than in BALB/c mice. These data suggest that the higher number of arterial branches and collaterals in C57BL/6 mice yields a lower blood flow per cerebral artery.

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Year:  2015        PMID: 25833343      PMCID: PMC4640258          DOI: 10.1038/jcbfm.2015.50

Source DB:  PubMed          Journal:  J Cereb Blood Flow Metab        ISSN: 0271-678X            Impact factor:   6.200


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