Literature DB >> 25833043

Simian Immunodeficiency Virus SIVsab Infection of Rhesus Macaques as a Model of Complete Immunological Suppression with Persistent Reservoirs of Replication-Competent Virus: Implications for Cure Research.

Dongzhu Ma1, Cuiling Xu1, Anthony R Cillo2, Benjamin Policicchio3, Jan Kristoff3, George Haret-Richter1, John W Mellors2, Ivona Pandrea4, Cristian Apetrei5.   

Abstract

Simian immunodeficiency virus SIVsab infection is completely controlled in rhesus macaques (RMs) through functional immune responses. We report that in SIVsab-infected RMs, (i) viral replication is controlled to <0 to 3 copies/ml, (ii) about one-third of the virus strains in reservoirs are replication incompetent, and (iii) rebounding virus after CD8(+) cell depletion is replication competent and genetically similar to the original virus stock, suggesting early reservoir seeding. This model permits assessment of strategies aimed at depleting the reservoir without multidrug antiretroviral therapy.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 25833043      PMCID： PMC4442440          DOI： 10.1128/JVI.00256-15

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  42 in total

1.  High frequencies of resting CD4+ T cells containing integrated viral DNA are found in rhesus macaques during acute lentivirus infections.

Authors:  Yoshiaki Nishimura; Reza Sadjadpour; Joseph J Mattapallil; Tatsuhiko Igarashi; Wendy Lee; Alicia Buckler-White; Mario Roederer; Tae-Wook Chun; Malcolm A Martin
Journal:  Proc Natl Acad Sci U S A       Date:  2009-04-27       Impact factor: 11.205

2.  Simian immunodeficiency virus SIVagm.sab infection of Caribbean African green monkeys: a new model for the study of SIV pathogenesis in natural hosts.

Authors:  Ivona Pandrea; Cristian Apetrei; Jason Dufour; Nora Dillon; Joseph Barbercheck; Michael Metzger; Béatrice Jacquelin; Rudolf Bohm; Preston A Marx; Françoise Barre-Sinoussi; Vanessa M Hirsch; Michaela C Müller-Trutwin; Andrew A Lackner; Ronald S Veazey
Journal:  J Virol       Date:  2006-05       Impact factor: 5.103

3.  Effect of a short-term HAART on SIV load in macaque tissues is dependent on time of initiation and antiviral diffusion.

Authors:  Olivier Bourry; Abdelkrim Mannioui; Pierre Sellier; Camille Roucairol; Lucie Durand-Gasselin; Nathalie Dereuddre-Bosquet; Henri Benech; Pierre Roques; Roger Le Grand
Journal:  Retrovirology       Date:  2010-09-26       Impact factor: 4.602

4.  Viremic control and viral coreceptor usage in two HIV-1-infected persons homozygous for CCR5 Δ32.

Authors:  Timothy J Henrich; Emily Hanhauser; Zixin Hu; Hans-Jürgen Stellbrink; Christian Noah; Jeffrey N Martin; Steven G Deeks; Daniel R Kuritzkes; Florencia Pereyra
Journal:  AIDS       Date:  2015-05-15       Impact factor: 4.177

5.  Antiretroviral treatment start-time during primary SIV(mac) infection in macaques exerts a different impact on early viral replication and dissemination.

Authors:  Pierre Sellier; Abdelkrim Mannioui; Olivier Bourry; Nathalie Dereuddre-Bosquet; Benoit Delache; Patricia Brochard; Julien Calvo; Sophie Prévot; Pierre Roques
Journal:  PLoS One       Date:  2010-05-11       Impact factor: 3.240

6.  Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection.

Authors:  Brandon F Keele; Elena E Giorgi; Jesus F Salazar-Gonzalez; Julie M Decker; Kimmy T Pham; Maria G Salazar; Chuanxi Sun; Truman Grayson; Shuyi Wang; Hui Li; Xiping Wei; Chunlai Jiang; Jennifer L Kirchherr; Feng Gao; Jeffery A Anderson; Li-Hua Ping; Ronald Swanstrom; Georgia D Tomaras; William A Blattner; Paul A Goepfert; J Michael Kilby; Michael S Saag; Eric L Delwart; Michael P Busch; Myron S Cohen; David C Montefiori; Barton F Haynes; Brian Gaschen; Gayathri S Athreya; Ha Y Lee; Natasha Wood; Cathal Seoighe; Alan S Perelson; Tanmoy Bhattacharya; Bette T Korber; Beatrice H Hahn; George M Shaw
Journal:  Proc Natl Acad Sci U S A       Date:  2008-05-19       Impact factor: 11.205

7.  Acute loss of intestinal CD4+ T cells is not predictive of simian immunodeficiency virus virulence.

Authors:  Ivona V Pandrea; Rajeev Gautam; Ruy M Ribeiro; Jason M Brenchley; Isolde F Butler; Melissa Pattison; Terri Rasmussen; Preston A Marx; Guido Silvestri; Andrew A Lackner; Alan S Perelson; Daniel C Douek; Ronald S Veazey; Cristian Apetrei
Journal:  J Immunol       Date:  2007-09-01       Impact factor: 5.422

8.  HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation.

Authors:  Nicolas Chomont; Mohamed El-Far; Petronela Ancuta; Lydie Trautmann; Francesco A Procopio; Bader Yassine-Diab; Geneviève Boucher; Mohamed-Rachid Boulassel; Georges Ghattas; Jason M Brenchley; Timothy W Schacker; Brenna J Hill; Daniel C Douek; Jean-Pierre Routy; Elias K Haddad; Rafick-Pierre Sékaly
Journal:  Nat Med       Date:  2009-06-21       Impact factor: 53.440

9.  Dynamics of viral replication in blood and lymphoid tissues during SIVmac251 infection of macaques.

Authors:  Abdelkrim Mannioui; Olivier Bourry; Pierre Sellier; Benoit Delache; Patricia Brochard; Thibault Andrieu; Bruno Vaslin; Ingrid Karlsson; Pierre Roques; Roger Le Grand
Journal:  Retrovirology       Date:  2009-11-23       Impact factor: 4.602

10.  Profound CD4+/CCR5+ T cell expansion is induced by CD8+ lymphocyte depletion but does not account for accelerated SIV pathogenesis.

Authors:  Afam Okoye; Haesun Park; Mukta Rohankhedkar; Lia Coyne-Johnson; Richard Lum; Joshua M Walker; Shannon L Planer; Alfred W Legasse; Andrew W Sylwester; Michael Piatak; Jeffrey D Lifson; Donald L Sodora; Francois Villinger; Michael K Axthelm; Joern E Schmitz; Louis J Picker
Journal:  J Exp Med       Date:  2009-06-22       Impact factor: 14.307
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  10 in total

1.  Nonhuman Primate Testing of the Impact of Different Regulatory T Cell Depletion Strategies on Reactivation and Clearance of Latent Simian Immunodeficiency Virus.

Authors:  Ranjit Sivanandham; Adam J Kleinman; Paola Sette; Egidio Brocca-Cofano; Sindhuja Murali Kilapandal Venkatraman; Benjamin B Policicchio; Tianyu He; Cuiling Xu; Julia Swarthout; Zhirui Wang; Ivona Pandrea; Cristian Apetrei
Journal:  J Virol       Date:  2020-09-15       Impact factor: 5.103

2.  Cutting Edge: T Regulatory Cell Depletion Reactivates Latent Simian Immunodeficiency Virus (SIV) in Controller Macaques While Boosting SIV-Specific T Lymphocytes.

Authors:  Tianyu He; Egidio Brocca-Cofano; Benjamin B Policicchio; Ranjit Sivanandham; Rajeev Gautam; Kevin D Raehtz; Cuiling Xu; Ivona Pandrea; Cristian Apetrei
Journal:  J Immunol       Date:  2016-11-11       Impact factor: 5.422

3.  Changes to the Simian Immunodeficiency Virus (SIV) Reservoir and Enhanced SIV-Specific Responses in a Rhesus Macaque Model of Functional Cure after Serial Rounds of Romidepsin Administrations.

Authors:  Adam J Kleinman; Sindhuja Sivanandham; Paola Sette; Ranjit Sivanandham; Benjamin B Policicchio; Cuiling Xu; Ellen Penn; Egidio Brocca-Cofano; Quentin Le Hingrat; Dongzhu Ma; Ivona Pandrea; Cristian Apetrei
Journal:  J Virol       Date:  2022-05-31       Impact factor: 6.549

4.  Lack of Specific Regulatory T Cell Depletion and Cytoreduction Associated with Extensive Toxicity After Administration of Low and High Doses of Cyclophosphamide.

Authors:  Adam J Kleinman; Ranjit Sivanandham; Paola Sette; Egidio Brocca-Cofano; Colin McAndrews; Brandon F Keele; Ivona Pandrea; Cristian Apetrei
Journal:  AIDS Res Hum Retroviruses       Date:  2021-06-08       Impact factor: 2.205

Review 5.  Animal Models for HIV Cure Research.

Authors:  Benjamin B Policicchio; Ivona Pandrea; Cristian Apetrei
Journal:  Front Immunol       Date:  2016-01-28       Impact factor: 7.561

6.  Multi-dose Romidepsin Reactivates Replication Competent SIV in Post-antiretroviral Rhesus Macaque Controllers.

Authors:  Benjamin B Policicchio; Cuiling Xu; Egidio Brocca-Cofano; Kevin D Raehtz; Tianyu He; Dongzhu Ma; Hui Li; Ranjit Sivanandham; George S Haret-Richter; Tammy Dunsmore; Anita Trichel; John W Mellors; Beatrice H Hahn; George M Shaw; Ruy M Ribeiro; Ivona Pandrea; Cristian Apetrei
Journal:  PLoS Pathog       Date:  2016-09-15       Impact factor: 6.823

Review 7.  Regulatory T Cells As Potential Targets for HIV Cure Research.

Authors:  Adam J Kleinman; Ranjit Sivanandham; Ivona Pandrea; Claire A Chougnet; Cristian Apetrei
Journal:  Front Immunol       Date:  2018-04-13       Impact factor: 7.561

8.  Macrophage-associated wound healing contributes to African green monkey SIV pathogenesis control.

Authors:  Fredrik Barrenas; Kevin Raehtz; Cuiling Xu; Lynn Law; Richard R Green; Guido Silvestri; Steven E Bosinger; Andrew Nishida; Qingsheng Li; Wuxun Lu; Jianshui Zhang; Matthew J Thomas; Jean Chang; Elise Smith; Jeffrey M Weiss; Reem A Dawoud; George H Richter; Anita Trichel; Dongzhu Ma; Xinxia Peng; Jan Komorowski; Cristian Apetrei; Ivona Pandrea; Michael Gale
Journal:  Nat Commun       Date:  2019-11-08       Impact factor: 14.919

Review 9.  Challenges and Opportunities of Therapies Targeting Early Life Immunity for Pediatric HIV Cure.

Authors:  Stella J Berendam; Ashley N Nelson; Bhrugu Yagnik; Ria Goswami; Tiffany M Styles; Margaret A Neja; Caroline T Phan; Sedem Dankwa; Alliyah U Byrd; Carolina Garrido; Rama R Amara; Ann Chahroudi; Sallie R Permar; Genevieve G Fouda
Journal:  Front Immunol       Date:  2022-07-13       Impact factor: 8.786

10.  African green monkeys avoid SIV disease progression by preventing intestinal dysfunction and maintaining mucosal barrier integrity.

Authors:  Kevin D Raehtz; Fredrik Barrenäs; Cuiling Xu; Kathleen Busman-Sahay; Audrey Valentine; Lynn Law; Dongzhu Ma; Benjamin B Policicchio; Viskam Wijewardana; Egidio Brocca-Cofano; Anita Trichel; Michael Gale; Brandon F Keele; Jacob D Estes; Cristian Apetrei; Ivona Pandrea
Journal:  PLoS Pathog       Date:  2020-03-02       Impact factor: 6.823
  10 in total

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