INTRODUCTION: Myopericytoma is a perivascular neoplasm commonly found in the skin and soft tissue of extremities. These lesions often exhibit concentric vascular proliferation of spindle shaped myoid cells. METHODS/ RESULTS: We present a case of a 76-year old male who was diagnosed with myopericytoma and subsequent cytogenetic analysis found a highly abnormal karyotype. This karyotype includes cytogenetic mutations that have not been described in previous case studies of myopericytoma. CONCLUSIONS: Some of these aberrations occur on genes that are involved in hedgehog signaling as well as pericyte proliferation, indicating a potential pericyte origin for myopericytoma tumors.
INTRODUCTION:Myopericytoma is a perivascular neoplasm commonly found in the skin and soft tissue of extremities. These lesions often exhibit concentric vascular proliferation of spindle shaped myoid cells. METHODS/ RESULTS: We present a case of a 76-year old male who was diagnosed with myopericytoma and subsequent cytogenetic analysis found a highly abnormal karyotype. This karyotype includes cytogenetic mutations that have not been described in previous case studies of myopericytoma. CONCLUSIONS: Some of these aberrations occur on genes that are involved in hedgehog signaling as well as pericyte proliferation, indicating a potential pericyte origin for myopericytoma tumors.
Authors: M S Dray; S W McCarthy; A A Palmer; S F Bonar; P D Stalley; V Marjoniemi; E Millar; R A Scolyer Journal: J Clin Pathol Date: 2006-01 Impact factor: 3.411
Authors: R L Johnson; A L Rothman; J Xie; L V Goodrich; J W Bare; J M Bonifas; A G Quinn; R M Myers; D R Cox; E H Epstein; M P Scott Journal: Science Date: 1996-06-14 Impact factor: 47.728
Authors: Anna Dahlén; Christopher D M Fletcher; Fredrik Mertens; Jonathan A Fletcher; Antonio R Perez-Atayde; M John Hicks; Maria Debiec-Rychter; Raf Sciot; Johan Wejde; Rikard Wedin; Nils Mandahl; Ioannis Panagopoulos Journal: Am J Pathol Date: 2004-05 Impact factor: 4.307
Authors: Fady M Mikhail; Kadreya A Serry; Nadia Hatem; Zeinab I Mourad; Hala M Farawela; Dalal M El Kaffash; Lionel Coignet; Giuseppina Nucifora Journal: Cancer Genet Cytogenet Date: 2002-05