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Literature DB >> 25828744

Heme oxygenase-1 suppresses the apoptosis of acute myeloid leukemia cells via the JNK/c-JUN signaling pathway.

Xiaojing Lin¹, Qin Fang², Shuya Chen¹, Nana Zhe¹, Qixiang Chai¹, Meisheng Yu¹, Yaming Zhang³, Ziming Wang³, Jishi Wang⁴.

Abstract

There are few studies on the correlation between heme oxygenase-1 (HO-1) and acute myeloid leukemia (AML). We found that HO-1 was aberrantly overexpressed in the majority of AML patients, especially in patients with acute monocytic leukemia (M5) and leukocytosis, and inhibited the apoptosis of HL-60 and U937 cells. Moreover, silencing HO-1 prolonged the survival of xenograft mouse models. Further studies demonstrated that HO-1 suppressed the apoptosis of AML cells through activating the JNK/c-JUN signaling pathway. These data indicate a molecular role of HO-1 in inhibiting cell apoptosis, allowing it to be a potential target for treating AML.

Entities: Disease Gene Species

Keywords: Acute myeloid leukemia; Apoptosis; Heme oxygenase-1; JNK/c-JUN; Signaling pathway

Mesh：

Substances：

Year: 2015 PMID： 25828744 DOI： 10.1016/j.leukres.2015.02.009

Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156

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Cited

15 in total

1. HIF-1α inhibition by 2-methoxyestradiol induces cell death via activation of the mitochondrial apoptotic pathway in acute myeloid leukemia.

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Journal: Cancer Biol Ther Date: 2016-04-15 Impact factor: 4.742

2. MicroRNA-1304 suppresses human non-small cell lung cancer cell growth in vitro by targeting heme oxygenase-1.

Authors: Cheng-Gang Li; Meng-Fan Pu; Chun-Zhu Li; Man Gao; Ming-Xia Liu; Cun-Zhi Yu; Hong Yan; Chun Peng; Yang Zhao; Yu Li; Ze-Long Ma; Xin-Ming Qi; Yi-Zheng Wang; Ling-Ling Miao; Jin Ren
Journal: Acta Pharmacol Sin Date: 2016-09-19 Impact factor: 6.150

3. Non-competitive heme oxygenase-1 activity inhibitor reduces non-small cell lung cancer glutathione content and regulates cell proliferation.

Authors: Mariarita Spampinato; Giuseppe Sferrazzo; Valeria Pittalà; Michelino Di Rosa; Luca Vanella; Loredana Salerno; Valeria Sorrenti; Giuseppe Carota; Nunziatina Parrinello; Marco Raffaele; Daniele Tibullo; Giovanni Li Volti; Ignazio Barbagallo
Journal: Mol Biol Rep Date: 2020-02-13 Impact factor: 2.316

4. Nrf2 overexpression increases the resistance of acute myeloid leukemia to cytarabine by inhibiting replication factor C4.

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5. The mutual regulatory loop between TPTEP1 and miR-1303 in leukemogenesis of acute myeloid leukemia.

Authors: Li Li; Weidong Zhao
Journal: Cancer Cell Int Date: 2021-05-13 Impact factor: 5.722

6. Interferon gamma-induced apoptosis of head and neck squamous cell carcinoma is connected to indoleamine-2,3-dioxygenase via mitochondrial and ER stress-associated pathways.

Authors: Siraj M El Jamal; Erin B Taylor; Zakaria Y Abd Elmageed; Abdulhadi A Alamodi; Denis Selimovic; Abdulaziz Alkhateeb; Matthias Hannig; Sofie Y Hassan; Simeon Santourlidis; Paul L Friedlander; Youssef Haikel; Srinivasan Vijaykumar; Emad Kandil; Mohamed Hassan
Journal: Cell Div Date: 2016-08-02 Impact factor: 5.130

Heme oxygenase-1 suppresses the apoptosis of acute myeloid leukemia cells via the JNK/c-JUN signaling pathway.

1. HIF-1α inhibition by 2-methoxyestradiol induces cell death via activation of the mitochondrial apoptotic pathway in acute myeloid leukemia.

2. MicroRNA-1304 suppresses human non-small cell lung cancer cell growth in vitro by targeting heme oxygenase-1.

3. Non-competitive heme oxygenase-1 activity inhibitor reduces non-small cell lung cancer glutathione content and regulates cell proliferation.

4. Nrf2 overexpression increases the resistance of acute myeloid leukemia to cytarabine by inhibiting replication factor C4.

5. The mutual regulatory loop between TPTEP1 and miR-1303 in leukemogenesis of acute myeloid leukemia.

6. Interferon gamma-induced apoptosis of head and neck squamous cell carcinoma is connected to indoleamine-2,3-dioxygenase via mitochondrial and ER stress-associated pathways.

Review 7. HO-1 Induction in Cancer Progression: A Matter of Cell Adaptation.

Review 8. Extinguishing the Embers: Targeting AML Metabolism.

Review 9. Clinical Significance of Heme Oxygenase 1 in Tumor Progression.

10. Targeting of heme oxygenase-1 attenuates the negative impact of Ikaros isoform 6 in adult BCR-ABL1-positive B-ALL.