Literature DB >> 25828529

Nutrient stress revamps cancer cell metabolism.

Jorge Moscat1, Adam Richardson1, Maria T Diaz-Meco1.   

Abstract

Efforts to identify new therapeutic targets in cancer primarily focused on oncogenes and tumor suppressor genes, and their mechanisms of action. However, there is an emerging alternative strategy that involves identification of target proteins that are not encoded by oncogenes, but are, nonetheless, required to accommodate cancer-specific stresses.

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Year:  2015        PMID： 25828529      PMCID： PMC4423079          DOI： 10.1038/cr.2015.38

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  10 in total

1.  Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis.

Authors:  Jason W Locasale; Alexandra R Grassian; Tamar Melman; Costas A Lyssiotis; Katherine R Mattaini; Adam J Bass; Gregory Heffron; Christian M Metallo; Taru Muranen; Hadar Sharfi; Atsuo T Sasaki; Dimitrios Anastasiou; Edouard Mullarky; Natalie I Vokes; Mika Sasaki; Rameen Beroukhim; Gregory Stephanopoulos; Azra H Ligon; Matthew Meyerson; Andrea L Richardson; Lynda Chin; Gerhard Wagner; John M Asara; Joan S Brugge; Lewis C Cantley; Matthew G Vander Heiden
Journal:  Nat Genet       Date:  2011-07-31       Impact factor: 38.330

2.  Control of nutrient stress-induced metabolic reprogramming by PKCζ in tumorigenesis.

Authors:  Li Ma; Yongzhen Tao; Angeles Duran; Victoria Llado; Anita Galvez; Jennifer F Barger; Elias A Castilla; Jing Chen; Tomoko Yajima; Aleksey Porollo; Mario Medvedovic; Laurence M Brill; David R Plas; Stefan J Riedl; Michael Leitges; Maria T Diaz-Meco; Adam D Richardson; Jorge Moscat
Journal:  Cell       Date:  2013-01-31       Impact factor: 41.582

3.  Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation.

Authors:  Jiangbin Ye; Anthony Mancuso; Xuemei Tong; Patrick S Ward; Jing Fan; Joshua D Rabinowitz; Craig B Thompson
Journal:  Proc Natl Acad Sci U S A       Date:  2012-04-16       Impact factor: 11.205

4.  cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions.

Authors:  Linchong Sun; Libing Song; Qianfen Wan; Gongwei Wu; Xinghua Li; Yinghui Wang; Jin Wang; Zhaoji Liu; Xiuying Zhong; Xiaoping He; Shengqi Shen; Xin Pan; Ailing Li; Yulan Wang; Ping Gao; Huiru Tang; Huafeng Zhang
Journal:  Cell Res       Date:  2015-03-20       Impact factor: 25.617

5.  An evaluation of tumor oxygenation and gene expression in patients with early stage non-small cell lung cancers.

Authors:  Quynh-Thu Le; Eunice Chen; Ali Salim; Hongbin Cao; Christina S Kong; Richard Whyte; Jessica Donington; Walter Cannon; Heather Wakelee; Robert Tibshirani; John D Mitchell; Donna Richardson; Ken J O'Byrne; Albert C Koong; Amato J Giaccia
Journal:  Clin Cancer Res       Date:  2006-03-01       Impact factor: 12.531

6.  Metabolic reprogramming of stromal fibroblasts through p62-mTORC1 signaling promotes inflammation and tumorigenesis.

Authors:  Maria T Diaz-Meco; Jorge Moscat; Tania Valencia; Ji Young Kim; Shadi Abu-Baker; Jorge Moscat-Pardos; Christopher S Ahn; Miguel Reina-Campos; Angeles Duran; Elias A Castilla; Christian M Metallo
Journal:  Cancer Cell       Date:  2014-07-04       Impact factor: 31.743

Review 7.  Understanding the Warburg effect: the metabolic requirements of cell proliferation.

Authors:  Matthew G Vander Heiden; Lewis C Cantley; Craig B Thompson
Journal:  Science       Date:  2009-05-22       Impact factor: 47.728

8.  Functional genomics reveal that the serine synthesis pathway is essential in breast cancer.

Authors:  Richard Possemato; Kevin M Marks; Yoav D Shaul; Michael E Pacold; Dohoon Kim; Kıvanç Birsoy; Shalini Sethumadhavan; Hin-Koon Woo; Hyun G Jang; Abhishek K Jha; Walter W Chen; Francesca G Barrett; Nicolas Stransky; Zhi-Yang Tsun; Glenn S Cowley; Jordi Barretina; Nada Y Kalaany; Peggy P Hsu; Kathleen Ottina; Albert M Chan; Bingbing Yuan; Levi A Garraway; David E Root; Mari Mino-Kenudson; Elena F Brachtel; Edward M Driggers; David M Sabatini
Journal:  Nature       Date:  2011-08-18       Impact factor: 49.962

9.  Serine is a natural ligand and allosteric activator of pyruvate kinase M2.

Authors:  Barbara Chaneton; Petra Hillmann; Liang Zheng; Agnès C L Martin; Oliver D K Maddocks; Achuthanunni Chokkathukalam; Joseph E Coyle; Andris Jankevics; Finn P Holding; Karen H Vousden; Christian Frezza; Marc O'Reilly; Eyal Gottlieb
Journal:  Nature       Date:  2012-10-14       Impact factor: 49.962

10.  Quantitative flux analysis reveals folate-dependent NADPH production.

Authors:  Jing Fan; Jiangbin Ye; Jurre J Kamphorst; Tomer Shlomi; Craig B Thompson; Joshua D Rabinowitz
Journal:  Nature       Date:  2014-05-04       Impact factor: 49.962
  10 in total
  2 in total

Review 1.  Karyotype Aberrations in Action: The Evolution of Cancer Genomes and the Tumor Microenvironment.

Authors:  Nicolaas C Baudoin; Mathew Bloomfield
Journal:  Genes (Basel)       Date:  2021-04-12       Impact factor: 4.096

2.  Exploration of the molecular mechanism of prostate cancer based on mRNA and miRNA expression profiles.

Authors:  Xing Zhang; YuYan Sun; Peng Wang; Changfu Yang; Shengwei Li
Journal:  Onco Targets Ther       Date:  2017-06-29       Impact factor: 4.147
  2 in total

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