Fernanda Sales Luiz Vianna1, Marcelo Zagonel de Oliveira2, Maria Teresa Vieira Sanseverino3, Elaine Faria Morelo4, Dacio de Lyra Rabello Neto5, Jorge Lopez-Camelo6, Suzi Alves Camey7, Lavinia Schuler-Faccini8. 1. INAGEMP - Instituto Nacional de Genética Médica Populacional, Porto Alegre, Brazil; Teratogen Information Service, Medical Genetics Service, Hospital de Clínicas de Porto Alegre, Brazil; Genetics Department, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Postgraduate Program in Epidemiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil. 2. INAGEMP - Instituto Nacional de Genética Médica Populacional, Porto Alegre, Brazil; Genetics Department, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. 3. INAGEMP - Instituto Nacional de Genética Médica Populacional, Porto Alegre, Brazil; Teratogen Information Service, Medical Genetics Service, Hospital de Clínicas de Porto Alegre, Brazil. 4. Programa Nacional da Hanseníase, Brasília, Brazil. 5. Secretaria de Vigilância em Saúde, Ministério da Saúde, Brasília, Brazil. 6. ECLAMC (Latin-American Collaborative Study of Congenital Malformations) in IMBICE, Instituto Multidisciplinario de Biologia Celular, La Plata, Argentina; ECLAMC in CEMIC, Centro de Educación Médica e Investigación Clínica, Buenos Aires, Argentina. 7. Postgraduate Program in Epidemiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil. 8. INAGEMP - Instituto Nacional de Genética Médica Populacional, Porto Alegre, Brazil; Teratogen Information Service, Medical Genetics Service, Hospital de Clínicas de Porto Alegre, Brazil; Genetics Department, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. Electronic address: lavinia.faccini@ufrgs.br.
Abstract
INTRODUCTION: Thalidomide causes congenital defects in children, such as limb reduction defects. Currently, it is used for a few indications; in Brazil, where leprosy is endemic, thalidomide is used for the treatment of erythema nodosum leprosum, and recent cases of thalidomide embryopathy have been reported. METHODS: We analyzed the frequency of births with phenotypes consistent with thalidomide embryopathy (TEP) and correlated this with the distribution of thalidomide and the prevalence of leprosy between 2005 and 2010 in Brazil. RESULTS: A total of 5,889,210 thalidomide tablets were distributed; the prevalence of limb reduction defects was 1.60 (CI95%: 1.54-1.66) and TEP was 0.11 (CI95%: 0.10-0.13) per 10,000 births. Poisson regression showed an increase in cases of TEP and limb reduction defects per 100,000 tablets dispensed. Clusters and geographical isolates were identified in several regions. CONCLUSIONS: There is a correlation between thalidomide and TEP showing that thalidomide embryopathy should be monitored in countries where this medication is available.
INTRODUCTION:Thalidomide causes congenital defects in children, such as limb reduction defects. Currently, it is used for a few indications; in Brazil, where leprosy is endemic, thalidomide is used for the treatment of erythema nodosum leprosum, and recent cases of thalidomideembryopathy have been reported. METHODS: We analyzed the frequency of births with phenotypes consistent with thalidomideembryopathy (TEP) and correlated this with the distribution of thalidomide and the prevalence of leprosy between 2005 and 2010 in Brazil. RESULTS: A total of 5,889,210 thalidomide tablets were distributed; the prevalence of limb reduction defects was 1.60 (CI95%: 1.54-1.66) and TEP was 0.11 (CI95%: 0.10-0.13) per 10,000 births. Poisson regression showed an increase in cases of TEP and limb reduction defects per 100,000 tablets dispensed. Clusters and geographical isolates were identified in several regions. CONCLUSIONS: There is a correlation between thalidomide and TEP showing that thalidomideembryopathy should be monitored in countries where this medication is available.
Authors: Lavinia Schüler-Faccini; Maria Teresa Vieira Sanseverino; Alberto Mantovani Abeche; Fernanda Sales Luiz Vianna; Lucas Rosa Fraga; Anastacia Guimaraes Rocha; André Anjos da Silva; Paulo Ricardo Assis de Souza; Artur Hartmann Hilgert; Camila Pocharski Barbosa; Caroline Grasso Kauppinem; Daniela Fernandes Martins; Daniela Silva Santos; Gabriel Henrique Colpes; Gabriela Ecco; Helena Margot Flores Soares da Silva; Louise Piva Penteado; Tatiane Dos Santos Journal: Genet Mol Biol Date: 2019-04-11 Impact factor: 1.771
Authors: Débora Gusmão Melo; Maria Teresa Vieira Sanseverino; Thanyse de Oliveira Schmalfuss; Mariela Larrandaburu Journal: Front Public Health Date: 2021-11-02
Authors: Zachary A Klase; Svetlana Khakhina; Adriano De Bernardi Schneider; Michael V Callahan; Jill Glasspool-Malone; Robert Malone Journal: PLoS Negl Trop Dis Date: 2016-08-25
Authors: Julia do Amaral Gomes; Thayne Woycinck Kowalski; Lucas Rosa Fraga; Gabriel S Macedo; Maria Teresa Vieira Sanseverino; Lavínia Schuler-Faccini; Fernanda Sales Luiz Vianna Journal: Sci Rep Date: 2019-08-06 Impact factor: 4.379